N - Nitrosamines: He hōʻike hōʻikeʻo Ames i hoʻonuiʻia me Hamster Liver S9

Nā hua'ōlelo: n - NITSORAMINES, NDSRIS, OCDD 471, Hoʻonuiʻia nā hōʻikeʻo S9ster S9

Iwapi aku

N -

N »nitrosamines (NDSris), me ka papa kuhikuhi R1 (R2) N - wai, holoi, bakona, nā keiki kāne, me nā kānaka hana lāʻau, et. e hoʻomohala pū lākou i ka wā hana lāʻau lapaʻau lāʻau. ʻO NDSRIS ka gonottix, e hōʻeha aiʻo DNA i ka pōʻino a me ka maʻi maʻi, aʻaʻole hiki i kā lākou pilikia haʻahaʻa ke hōʻeha. ʻO kaʻoihana pūnaewele no ka noiʻi ma ka mea Kūkā (marc) ua heluʻia i nāʻano heihei (NDMA) ʻO kaʻaha kūkā o ka honua no ka hanaʻana i nā ponoʻenehana no ka hoʻopaʻa inoaʻana o nā lāʻau lapaʻau no ka hoʻohanaʻana i ka carcinonicity kiʻekiʻe. ʻO ka Carcinorcity o NDDRR i mua o ko lākou metabolites, a me ka hydroxy e like me ka hanaʻana o DNA i ka hana a Dya.

Fig.1. Mechanism o ka carcinonicity o ndma

Hoʻonuiʻia nā hōʻike ames ams ma ka genotoxics assay o n - Nitrosamines imprities

Mai kona komoʻana i ka makahiki 1975,ʻo ka hōʻike a me ka hōʻikeʻana o ka Beant Mokuahi i ka loiloiʻana i nā mea kūʻai aku ma Genomanian. Wahi a ka hoʻokūkū hou i hoʻopukaʻia e nā Aurdies Medicanis Agency No laila, kaHoʻonui i nā hōʻike hoʻokolohua, hoʻomohalaʻia e ke kikowaena aupuni no ka noiʻiʻana i ka mea noiʻi (NCTR) ma lalo o ka pono o U.S. Inā hāʻawiʻia ka hōʻike hōʻikeʻo Ames maʻamau i kahi hopena maikaʻi,ʻaʻole pono keʻano hoʻonuiʻia Eia nō naʻe, inā he hopena maikaʻiʻole ka hopena,ʻoi aku ka loiloi e hoʻohana ana i ka ho'āʻoʻana e hoʻonuiʻia i ka hōʻike Ames Pono e hoʻihoʻi hou i ka hōʻike hoʻonui i kahi hopena maikaʻiʻole, he mea kūponoʻoleʻo Vivo Mika I nā hihia kahi i loaʻa ai ka hōʻike Vivo, he mea nui kahi loiloi loea e wehewehe i nāʻike. He mea nui ia e hoʻomaopopo i kekahi n - NITSORAMINE e hōʻike i nā mea hikiʻole ke hōʻoia i ka mālamaʻana i ka carcinogenic.

ʻO nā hōʻike e hoʻonui nei i nāʻano a me nā kūlana

Nā huahana e pili ana i nā huahana

ʻO Iphise, he alakaʻi i nā reigle koi no ka noiʻi vitro, me nā hana hana holomua o ka loiloi s9, ua hoʻomohala maikaʻi mākou i kaʻike muaʻana ma ka loiloi muaʻanaHamster Little S9). Ma hope o ka nānāʻana o Aseptic,ʻo nā hōʻike hoʻokolohuaʻo Metabolic ma Metabolic a me ka mana o nā hoʻokolohua

Eia kekahi, ua ulu hou Ipase i kahi hana kūikawā i ka noiʻi snootkisity ma Vitotexic

E pili ana i ka Iphise

Me nā makahiki o R & Dʻike, ua hoʻokumuʻiaʻo Iphuse i nāʻoihana noiʻi, nā mea kūʻai aku, nā mea kūʻai aku, etc. Hope a me nā kūkākūkā hou, a e hāʻawi mākou iāʻoe i keʻano he meleʻoluʻolu o 400 - 127 - 6686.