Carboxicyystetrasters (ces) i ka lāʻau lapaʻau lāʻau lapaʻau: reaction phenotyping a ddi

Nā hua'ōlelo: TRUIRED - DISIBECLES (DDI), Carboxytetemase, Ces2, car2

Meaʻai Iphase

Hōʻikeʻike

Carboxicyystetrasters (ces) nā kī nui hydrolytic i komo i loko o ka metabolism o ka nui o ka esterar - a me ka nui - nā lāʻau lapaʻau. I waena o kēia,Hale Kūʻaiʻo Carxboxyterase 1 (ces1)aNā kākuhi sarboxxyterase i 2 (ctes2)ʻo ia ka mea kaulana loa i nā kānaka. ʻO kā lākou māhele kiko a me ka substratity e hana i nā mea kiko'ī e hana i nā ces1 a me ces2 waena i ka hoʻomaopopoʻana i ka lāʻau lapaʻau lāʻau lapaʻau,ʻO ka lāʻau lapaʻau lāʻau lapaʻau, aʻO ka lāʻau lapaʻau - Nā lāʻau lapaʻaui nā mea akamai lāʻau lapaʻau.

Ces1 a me ces2: hoʻonohonoho a me nā hana hana

Ua hōʻike nuiʻiaʻo Carboxylyterase i 1Olae wala kalakupa. ^. Uaʻikeʻia kēia enzyme no kāna mau pālahalaha ākea,ʻo nā lāʻau lapaʻau e like me Oselllphivir, a me Caldidogrel. I ka hoʻohālikelikeʻana, carboxyyteteasese 2 (ces2) he nui loa i loko o ka'ōpū, no laila ua kapa pinepineʻia iaKa paxboxywtekete. ^. Hoʻopiliʻo Ces2 i kahi hana pivotal i loko o ka metabolism o nāʻoihana anticancer e like me ka turinotecan a me nā prodrutabine.

ʻO ka hōʻikeʻokoʻa o CES1 a me CES2 e hana iā lākou i nā mea koʻikoʻi koʻikoʻi ma Adme (Abs Subrip, Metabolism, Metabilim ʻO nā pahu Carxboxytetramake kekahi

Role i loko o ka lāʻau lapaʻau metabolic

ʻO ka lāʻau lapaʻau lāʻau lapaʻau he kumu kumuwaiwai no ka lāʻau lapaʻau o nā lāʻau lapaʻau. Ces1 a me ces2 e hoʻoikaika nui i ke kūpaʻa a me ka hapa - ola o Ester - nā mea hana a nā mea hanaʻole. Ces1 Ces2, e like me ke kapa o ka lole o ka mea nui loa, e pili ana ka mea mua i ka mea mua - Ka loiloi pehea e kōkua ai kēia mau mea e hoʻohui i nā molleboles mollecuka e kōkua i nā mea i kohoʻia e hoʻonui ai i ka lāʻau lapaʻau a me ka laweʻana.

ʻO ka hopena e pili ana i nā ces enzymes

Keʻano houHe mea pono e hoʻoholo i ke koina o ka enzyme kūpono no ka lāʻau lapaʻau lāʻau lapaʻau. ʻO nā CES1 a me nā CES2 e komo pinepine i kēia mau haʻawina e hoʻomaopopo i kā lākou mau hāʻawi kūikawā. ʻO ka hopena kūpono e hiki ai ke hoʻomaopopo i ka hoʻolālāʻana o nā prodrugs i hoʻolālāʻia no ka hanaʻana e CES1 a iʻole CES2, e hoʻomaikaʻi i ka biovailation a hoʻomaikaʻiʻia.

Ua hoʻohana nā mea noiʻi i nā uku uku iā Ces1 a me Ces2 enzymes, nā'Āpana Mīkini (no nā microxsitesttemase hana) ʻO ka pahuhopu ke hōʻemi i nāʻano likeʻole a hōʻoia i nā ala metabolic e hele pono ana.

Ces enzyme inomition a me ka lāʻau lapaʻau -

Ces enzyme i kahe hopohopo hopohopo ma muli o kona hiki ke lilo i ka lāʻau lapaʻau koʻikoʻi - Nā Kūlana Kūʻai Kūʻai. Hiki i ka bichingiting ces1 hiki ke hāʻawi i ka metabolism o kāna mau mea i kauʻia, e alakaʻi ana e hoʻonui i nā pae lāʻau a me ka nui. Pēlā nō,ʻo Ces2 i loko o ka'ōpū e hiki ke hōʻemi i ka hana prodrug project, hoʻohaʻahaʻa i ka hana kolohe.

Nui nā hana maikaʻi a me ka lāʻau lapaʻau lāʻau lapaʻau -ʻO nā lāʻau lapaʻau lāʻau lapaʻau e pili ana i kēia manawa e pili ana i ka nānāʻana no CES enzyme i ka mea i hoʻopaʻaʻia. Kōkua kēia i ka wānanaʻana i keʻano o ka lāʻau lapaʻau e hana ai i nā hui likeʻole hou a me nā hoʻolālāʻana i nā hoʻolālā Dosing Dosing e hōʻemi ai i ka pilikia.

No ka laʻana, CO -ʻO ka hoʻokeleʻana o kahi Inibitor me Mit1 Pēlā, ces2 i loko o ka wā e hoʻopili ai iā chemotherapy chemotherapy i ka hanaʻana o ka hana antinorcan, e hōʻemi ana i kāna hana antiniccer.

Noi ma ka noiʻi lāʻau lapaʻau

Ua liloʻo Carbixlyyterase i 1 (Ces1) a me Carboxlyterase i hāʻawiʻia 2 (CES2) i lilo i nā mea hana i loko o ka noiʻiʻana i kēia manawa. ʻO kā lākou mea nui loa:

• Ka wānanaʻana i ka lāʻau lapaʻau lāʻau metabolic.
• Ke lawe nei i ka hopena e pili ana i ka phenotyping no ka pololei encaute enzyme.
• Ka loiloiʻana i ka ces enzyme i ka lāʻau lapaʻau e wānana i ka lāʻau lapaʻau.
• Hoʻolālā CES - i hana i nā prodrugs no ka hoʻomaikaʻiʻana i ka lawe.

ʻO ka Role o Ces1 e like me ka carbixytesttase a me nā ces2 e like me ka mea noiʻi o ka Acteminal. Ma ka Hoʻohuiʻana i nā ces i ka hanaʻana i nā pōkā lāʻau hoʻomohala lāʻau, hiki i nāʻepekema ke hana i nā lāʻau lapaʻau maikaʻi.

Hopena

I ka hopena,ʻo Carboxyyteterasesese 1 a me Carboxtyletetetearase ADEMER 2 ma mua o nā mea hoʻoikaika kino a me ka palekana. ʻO ka mea nui i ka ces1 (Liver Carxboxtylenesese) a me Ces2 ʻO kaʻike hohonu o nā hana cesʻaʻole wale e hoʻoponopono wale i ka hoʻolālā lāʻau lapaʻau e hoʻopili ana i kaʻoihana kūleʻa e komo ana i ka mākeke o nā mea kūʻai aku.