1. Hoʻomaopopo: Hoʻomaopopo i nā microsome baby
I loko o ka hoʻolālā lāʻau lapaʻau i kēia manawa, wānana pehea e launa ai ka lāʻau lapaʻau i ke kino o ke kanaka, he koʻikoʻi ia no ka hōʻoiaʻana i ka loaʻaʻana o ka pono a me ka palekana.Kanaka olaʻo Microsomes(HLMS) i hoʻohana nuiʻia ma ka noiʻi lāʻau lapaʻau e hāʻawi ana i kahi hana no ka loiloiʻana i ka lāʻau lapaʻau no ka loiloiʻana. Uaʻike kēia mau noiʻi i nā mea noiʻi noiʻi pehea e hana ai he lāʻau lapaʻau ma mua o ka komoʻana i nā hoʻokolohua lapaʻauHōʻike kēiaʻatikala i ka role o nā moni keleponaʻo Microsomes i nā lāʻau lapaʻau lāʻau, pehea ko lākouʻano i ka hoʻomaikaʻiʻana i nā lāʻau lapaʻau no ka hoʻomaikaʻiʻana i nā hana lapaʻau
2. He aha nā modsosim?
ʻO nā moni o ke kanakaʻo Microsomes he mau mea hoʻokūkū i loaʻa mai i nā'āpana o ke kanaka. Loaʻa iā lākou nā mea nui e komo i loko o nā lāʻau lapaʻau lāʻau lapaʻau, kūikawā:Cytochrome p450 enzymes (cyp450s)- kuleana no ka bhase i ka metabolism, me ka oxdation, hydosexlation, a me kaʻaina.
Udp - glucuronosyltranseses (UGTS)- E pili ana i nā hopena o nā hana a nā phase II e like me ka glucurodidation, e hoʻonui ana i ka maʻi lāʻau lapaʻau no ka hoʻopiʻiʻana.
Lawelaweʻo hlms e like me ka'ōnaehana vitro no ka simulation counter metabolism Uaʻae kēia mau mea noiʻi e noi i nā alahele e aʻo ai i nā ala lāʻau lapaʻau, e hoʻoholo i nā hopena o ka hoʻomaʻemaʻeʻana ma mua o ka hoʻomakaʻana o nā hoʻokolokolo kanaka.
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ʻO Pharmaciaotics (PK) e pili ana i ka neʻeʻana o kahi lāʻau lapaʻau ma ke kino, me ka hoʻohuiʻana, ka hoʻolahaʻana, a me ka hoʻopiʻiʻana. Ma waena o kēia,ʻo Metabolism kahi mea nui e pili ana i ka hopena o ka lāʻau lapaʻau a me ka palekana, a me Hlms e pili ana i kēia kaʻina hana.ʻO ka paʻa metabolic- E hoʻoholo i ka hapalua - ola a me ke ola a me ka hoʻomaʻemaʻeʻana o kahi lāʻau lapaʻau, e hoʻoulu ana i nā'ōlelo hōʻike Dosage.
Ka hoʻokumuʻana o nā metabolites- E hōʻike ana i nā metablites ikaika a iʻole nā metablilites e pili ana i ka hopena lāʻau a iʻole ka palekana.
ʻO ka lāʻau lapaʻau - nā lāʻau lapaʻau lāʻau (ddis)
Ma ka nānāʻana i kēia mau mea, hiki i nā mea noiʻi ke wānana inā e mau ka lāʻau lapaʻau e lōʻihi a iʻole e koiʻia a pono paha e hana pinepineʻia.
4.ʻO nā noi o nā microsses o nā microsome i ka hoʻomohalaʻana i ka lāʻau lapaʻau
4.1 Ke wānana nei i ka metabolism a me ka hoʻomaʻemaʻe
Kōkuaʻo HLMS ke koho i ka wikiwiki o ka hoʻomaʻamaʻaʻana i ka lāʻau lapaʻau,ʻo ia ka mea e pili pololei ana i kāna mau hana a me ka pae kiʻekiʻe. Hiki i nā lāʻau lapaʻau me nā kumukūʻai kiʻekiʻe kiʻekiʻe ke koi aku i nā makana kiʻekiʻe aʻoi aku paha,ʻoiai e hōʻiliʻiliʻia nā metabolism4.2 ka loiloiʻana i ka lāʻau lapaʻau - Nā Kūlana Kūʻai (DDis)
Hiki i kekahi mau lāʻau lapaʻau ke hoʻonāukiuki a iʻole ke komoʻana i ka cyp450 enzymes, e alakaʻi ana i nā hopena hemahema i hui pūʻia me nā lāʻau lapaʻau'ē aʻe. HlM - Nā haʻawina e pili ana i nāʻoihana pharmaceratical eʻike i kēia mau pilikia ma mua o nā hoʻokolohua lapaʻau e hōʻoia ai i ka palekana maʻi.4.3 Kaʻikeʻana i nā metabolites
ʻO kekahi mau lāʻau lapaʻau e hana hou i nā metabolites e hiki ke alakaʻi i ka leʻaleʻa a me nā hopena maikaʻiʻole. Ke kōkua neiʻo Screen me HLMS i kēia mau metabolites, e hōʻemi ana i nā pilikia e pili ana i ka lāʻau lapaʻau (dili).5
5.1 Loaʻa
Uku - Pono -ʻoi aku ka maikaʻi o kaʻoihana ma mua o ka holo pihaʻana - Nā hoʻokolohua lapaʻau.Nā hopena hou aku - hāʻawi i nā hopena kūlike ma lalo o nā kūlana i hoʻopaʻaʻia.
High - Pihi kikowaena - hiki i ka loiloi wikiwikiʻana o nā moho o nā lāʻau lapaʻau nui.
5.2 Nā palena palena
Lacks piha piha piha -ʻaʻole ia he moʻokāki no nā mea lawe aku i pili i ka phase iii metabolism.ʻAʻole hiki ke loaʻa i nā hopena ola mimik
ʻO nā hiʻohiʻonaʻokoʻa -ʻaʻole hiki i nāʻikepili mai nā microsimes holoholonaʻaʻole i wānana i ka lāʻau lapaʻau kanaka kanaka.
6 .Hike i nā biosciences
Heansquar i loko o North Wales, Pennsylvania,Iphise bioscienceshe kiʻekiʻe koʻikoʻi a me ka mea kūʻai akuʻoi aku ka hoʻomaʻamaʻaʻana? Me kahi kūpaʻa ikaika e hoʻomaʻemaʻe i ka maikaʻi, hāʻawi kā mākou hui loea i nā mea hana aʻoi aku ma ka hana loea a me nā haumāna haumāna.7
ʻO Hlms Play kahi hana koʻikoʻi i kaʻikeʻana i ka lāʻau lapaʻau lāʻau, e hōʻoia ana i ka palekana, a me ka hoʻomaikaʻiʻana i nāʻano lāʻau lapaʻau. Ma ka hoʻohuiʻana i nā haʻawina HLM - Nā haʻawina i hoʻokumuʻia ma ke kaʻina hana hoʻomohala, hiki i nāʻoihana lāʻau lapaʻau e hoʻomaikaʻi i ka maikaʻi o ka lāʻau lapaʻau, a hoʻomaikaʻi i ka palekana o ka lāʻau lapaʻau.Ma Iphie biosciences, ua hana mākou i ke kākoʻoʻana i nā mea noiʻi me nā mea kūʻai aku kiʻekiʻe loa e hiki ai keʻano o ka lāʻau lapaʻau.
Nā hope hope: 2025 - 02 - 17 16:24:44