ʻO Plasma Protein Binding Binding Dynanacs

Nā Hua'ōlelo: ʻO ka diaysibrium equilibrium, ultrafiltration, plasma protein binding

Hōʻikeʻike

I ka noiʻiʻana o Pharmacolinetic, ʻO Plasma Protein Binding (PPB) A me ka ʻO ka heluʻana o ka helu plasma (brpp) lawelawe e like me nā mea hoʻoponopono pivotal o kahiʻano lāʻau lapaʻau a keʻano o ka hoʻopiliʻana, e pili ana i kāna absoring, ka hoʻolahaʻana, me ka hoʻolahaʻanaAdme) nā waiwai. E hōʻike ana i nā hoʻohuiʻO Plasma Protein Binding (PPB)Hōʻike i ka palena palena palena hoʻokaʻawaleʻoleʻia, e moni ai i ka moho aihue hana a me ka palekana. Acrearently E helu i kēia mau hiʻohiʻona me ka pololei, methodologies e like me ʻO ka dialysis equilibrium a Paltrafilterate he hana maʻamau,ʻoi aku ka loiloi Ka lāʻau lapaʻau - Nā lāʻau lapaʻau (DDI) A e hoʻokau nei i nā pihi Post Tuplodel.

Eqillibrium Dialysis (ed)

ʻO ka dialysis equilibrium heʻenehana biochemical clachemical no ke anaʻana i ka ppb a me brpp. 'ŌleloʻO ka polokalamu Dialysis equilibriumHoʻopili i nā keʻenaʻelua i hoʻokaʻawaleʻia e kahi semipermeble ʻO ka membrane equilibrium dialysis: hoʻokahiʻaoʻao i ka hui o ka macromolecule-ligand Ma mua o ka manawa,ʻaʻole e hoʻokaʻawale i nā ligands e neʻe ma waena o ka membrane distlilibrium a hiki i ka mea e like me nā'āpana o ka mīkini. Ma ke anaʻana i nā loina ligand ma kaʻaoʻao o ka buffer ma hope o ka kaulike, hiki i nā mea noiʻi ke koho i nā koina o Ligand. ʻO ka pono o ka Dialysibrium Distlilibrium ka mea kūpono loa ia, akāʻo ia ka manawa - ka wā - ʻO keʻano o ka'ōnaehana devlidibrium distlilibrium e lawe i 3 - 48 mau hola e hoʻohālikelike ai.

Rapid equilibrium dialysis (ʻulaʻula)

Rapid equilibrium distlilibrium(ʻULAʻULA)ʻO kahi hoʻololi kiʻekiʻe kiʻekiʻe o ka China Classic equilibrium i hoʻolālāʻia e wikiwiki a me keʻano o keʻano o nā molena liʻiliʻi I ka wikiwiki o Rapid Equilibrium, nā'āpana (e.g., plasma i kauʻia i nā papa o nā lāʻau lapaʻau. ʻO ka papa membrane memmanezed, ka hoʻolālā hoʻolālā a me ka hana paʻa e hiki ai ke loaʻa i ka equilibrium e hōʻea i kahi mau hola wale nō ma mua o ka pō. No ka mea, hikiʻole i ka lāʻau lapaʻau wale nō ke hele i ka membrane, ka heluʻana i kāna hana ma ke keʻena buffer ma hope o ka heluʻana i ka nui o ka heluʻana. ʻOi aku ka wikiwiki o kaʻulaʻula ma mua o nā mea waiwai equilibrium dialysis dialysis me kaʻole e hāʻawi i ka pololeiʻole o ka hoʻopiʻiʻana i kaʻulaʻula nui.

Paltrafilterate

ʻO ka Ultrabiltrateratratrat kahi rapid, menmrane-unbrane i hoʻohanaʻia e hoʻokaʻawale i nā molemani liʻiliʻi Ua kauʻia ka sample ma luna o kahi membrane semipermeable i ka nui o ka nui o ka pore E like me ka hōʻiliʻiliʻana o ka kānana ma kēlāʻaoʻao,ʻo ia wale nō ka hapa nui o ka loiloi; Ma ke anaʻana i kona nānāʻana, hiki i nā mea noiʻi ke hoʻoholo pono i nā lāʻau lapaʻau manuahi a iʻole nā ​​pae ligand. Hoʻohana nuiʻia kēia ala kiʻekiʻe ma ka lāʻau lapaʻau a me nā haʻawina adme e loiloi i ka hoʻopaʻaʻana i nā manawa incubation.

Nā hopena i loko o ka lāʻau lapaʻau - nā lāʻau lapaʻau lāʻau (ddis)

I nā lāʻau lapaʻau lāʻau lapaʻau,ʻelua mau mea hana e pili ana i nā pūnaewele like likeʻole i ka haʻaleleʻana i kekahi Hiki i kēia hoʻololi ke hoʻomaʻamaʻa i kāna mea kūpono a iʻole ka leʻaleʻa a hoʻololi i kona nui o ka hoʻolahaʻana a me ka hoʻomaʻemaʻe houʻana e like me kahi kūlike hou. Ke kūleʻa nei nā lāʻau lapaʻau me nā lāʻau plasma plasin kiʻekiʻe (PPB) a me keʻano o ka hoʻolālāʻana o Plasma i nā hoʻololiʻana o Plasma

Hopena

ʻO ka hoʻomaopopoʻana i ka Possma Pleasin Binding ʻO nāʻenehana e like me ka dialysis equilibrium (ed), rapid equilibrium dialysis (ʻulaʻula) ʻOiai e hoʻomau nei ka ED i ke kūlana gula no ka pololei, e hāʻawi i kaʻulaʻula i kahi kiʻekiʻe o ka wikiwiki. ʻO kēia mauʻano hana i nā lāʻau lapaʻau loiloi -ʻO nā lāʻau lapaʻau (DDis) E like me ka hoʻomaʻamaʻaʻana i nā lāʻau lapaʻau, ke kohoʻana i nā methodologies kūpono e loiloi i ka PPB a me BRPC e hoʻoponopono i nā hana lapaʻau. Hope loa, hoʻohui i kēia mau hana i loko o nā lāʻau lapaʻau lāʻau lapaʻau e hoʻonui ai i ko lākouʻano koʻikoʻi a me ka mālamaʻana i ka lāʻau lapaʻau