Ma ke kahua o ka biometical a me Molecular noiʻi,ʻike kaʻike kelepona no ka weheʻana i nā mea paʻakikī a me nā hana maʻi maʻi. I waena o kēia mau papa hana,trticomes-ʻO nā mea liʻiliʻi -ʻikeʻia akāʻoi aku ka nui o ka papa o ka mysosome - e pili ana i nā mea hana e pili ana i nāʻano rubs.Nā Rat TritomesHāʻawi i nāʻike koʻikoʻi ma ka hoʻonuiʻana i ka hana kuhina nui, nā kupuaʻana, a me nā makahiki likeʻole, e hana ana iā lākou i kahi kumuhana'ē aʻe o kaʻano loea likeʻole.

Hōʻike kēiaʻatikala i nā mea āpau o nā triato das

ʻO ka hoʻomaopopoʻana iā TritoSomes: kahi organille

ʻO Tristosoms kahi subtype o nā mysosope o nā mysosomes,ʻo ia ka mea mebrane - nā mea paʻa i hoʻopiliʻia i loko o ka degradate ocromolecules. ʻOiai he mau mea nui o nā mysosomes he nui o nā aniani hydrolytic, ua hoʻonuiʻia nā trutosoms i nāʻano chachemical a explibit

ʻO ka hua'ōlelo "Trictoomet" ua hoʻopuka muaʻia ma nā haʻawina e pili ana i nā subfracicate hou aʻe e hoʻohana ana i ka cedity likeʻole Ma ka hanaʻana i kēlā mau hana hana, ua hiki i nāʻepekema ke hoʻomaopopo i nā subpopulations-like tritoosmes, nā mea'ē aʻe, a me ka hana.

I nā stits, ua hoʻonuiʻia nā tritosoms i ka loaʻaʻana o kaʻoihana pūnaewele a me nā hōʻailona kiʻekiʻe o ka heluʻana i nāʻano cubcerllular.

Ka hoʻokaʻawaleʻana a me keʻano o nā tritosomes rat tritosomes

ʻO ka hoʻokaʻawaleʻana o nā trutosomes rat tritoosom e pili ana i ka sucrose a percoll gradied centrifugation ma hope o ka homogenization tissue. Hoʻohana pinepineʻia nā'ōpala o Livers, e like me nā hepatocytes e loaʻa ai nā hepatika a me nā bioxmically e like me nā subpopulations he nui.

ʻO nā hana nui i nā kaʻa kaʻa kaʻa kaʻa:

• Homogenizing stout a iʻole coninet tissue ma lalo o nā kūlana anuanu e mālama ai i ka ikaika enzymatic.
• ʻO nā meaʻokoʻa'ē aʻe e wehe i ka nuclei a me ka mitochondria.
• ʻO nā crident gradient gradient e hoʻokaʻawale i nā tritosoms tritosomes mai nā crossover a me nā vesicles a me nā vesicles'ē aʻe.
• ʻO nā mea e hoʻohui i nā mea waiwai e hoʻomaopopo ai i nā Tritoome - Nā hana kūikawā, e hoʻohana pinepine ana i nā māka e like me β - glucurodase, a me Arylsulfease.

Hoʻokahiʻia,ʻo Tritosomes e hoʻohanaʻia me ka hoʻohanaʻana i nā microscopy electron

No ke aha e hoʻohana ai i nā hiʻohiʻona rat no ke aʻoʻana i nā trutosoms?

ʻO nā rats kahiʻano hoʻohālike e like me nā mea aʻoaʻo a me nā mea noiʻi me ka metablicial ma muli o kā lākou mau mea like me ke kanaka, a hoʻopaʻaʻia i nā protocols laboratory. ʻO kaʻeke o ka rat, i loko, he kumu waiwai nui o ka mysosom enzyme a lawelawe i keʻano kūpono no ka hoʻopaʻaʻana i ka Endo -

He mea maikaʻi loa nā Tristosoms i kahi mea noiʻi i ka noiʻi ma luna:

• ʻO nā maʻiʻo LySosOmal
• Aging a me nā hanana
• Tissue - Nā metabolism kiko'ī
• ʻO ka lāʻau lapaʻau lāʻau lapaʻau a me ka leʻaleʻa

ʻO ka huiʻana i ka hoʻokaʻawaleʻana i nā tritoosmes mai ka rat tissue i hana iā lākou i kahi kumu nui no ka hoʻomaʻamaʻaʻana i nā maʻi maʻi maʻi.

Nā noiʻana o nā noi Tritome Tritoney i nā noiʻi biometical

1.ʻO ka mālamaʻanaʻo Lyosomal Storage (LSDS)

Ua hoʻonuiʻia nā Trutomesom i nā enzymes kūikawā Ke aʻo nei i kēia mau mea hana e kōkua ai i ka Elicudate pehea e alakaʻi ai i nā hemahema e hiki ke alakaʻi i ka hōʻiliʻiliʻana a me ka cellibunction dysfunction.

No ka laʻana, ua hoʻohana nā mea noiʻi i nā mele tritomes e hoʻomaopopo i nā ala ākeaʻaʻole i hilahila ka maʻi o nā lāʻau lapaʻauʻoi aku.

2.ʻO ka hoʻemiʻana a me Autophagic Decline

ʻO nāʻano likeʻole - Nā loli e pili ana i ka hana lyysosmal e hana ai i ka hallmark o ke kelepona. Ua hōʻikeʻo Tritoney i nā hana a me nāʻeha nui o ka hōʻiliʻiliʻana o Lipofuscin, i hoʻololiʻia e nā mea hana a me nāʻano o nāʻano selscent.

Hana kēia i nā tritosomes he mea waiwai waiwai no ka noiʻiʻana AGE - E pili ana i nā kaʻina hana degenerative, me nā mea e pili ana i ka pili i ka neurodegeneration a me nā kala.

3

ʻO Wysosomomes, me nā trutosomes, pili i ka hālāwai a me keʻano o ka xenobiotics. Ma ke aʻoʻana i nā TritoSomes Rat TritoSomes, hiki ke hoʻomaopopo i ka maikaʻi ʻO nā lāʻau lapaʻau a me nā mea hana a nā kaiāulu e hoʻoiliʻia ma ka pae cellarular.

Hiki ke kōkua pū i nā papa hana enzyme ma TrutoSosmes e hiki ke kōkua i ka wānanaʻana i ka metabolism.

4. Pili i ke koho balota

Uaʻaeʻo Rat Trictosomes i nā mea noiʻi e hoʻohālikelike ai i keʻano o ka mysosol e like me nāʻano likeʻole. He mea maikaʻi loa kēia i ka wā e aʻo ai i nāʻano kiʻi kiʻi kiʻi kiʻi kiʻi kiʻi.

Hoʻohanaʻia nāʻenehana loea i nā noiʻi trictoome

ʻO ke aʻoʻana o nā tritosmes e lawelawe i ka huiʻana o ka huiʻana a me nāʻano hana hou:

• ʻO nā mea e hoʻonui nei i nā mea waiwai e pili ana i ka helu helu o nā hydrolases.
• ʻO ka paleʻana o ke komohana a me ka nui o ka pīhoihoi no ka hōʻoia protein.
• Immunofluoresceencecence a me ka coccocal microscopy no nā haʻawina kūloko.
• ʻO nā lipidomics e loiloi i nā mea hoʻohui Membrane a me nā hiʻohiʻona mālama.

ʻO kēia mau mea hana e pono ai i nā mea noiʻi e hoʻohana ai i nā kuleana hana o Tritoosoms i nā phritooms i ke phritooms ma Celliular Phrinterilogy a me Pathophysity Mederage.

Nā palena a me nā hiʻohiʻona e hiki mai ana

ʻOiaiʻo Root Tritotome eʻimi nei i nā mea noiʻi he nui loa, e noho ana nā palena:

• Hiki i ka heterogenety o wilsosom ke hōʻoia i ka weheweheʻana i nā hopena subfracication.
• ʻO nā kiʻi - Pono nāʻano kiko'ī kūikawā e noʻonoʻoʻia i ka wā e loaʻa ai kaʻikepili extrapolating i ka biology kanaka.
• Pono ka hoʻololiʻana o nā protocols e hoʻomaikaʻi i nā mea hou ma waena o nā labs.

ʻOiaiʻo kēia mau pilikia, makemake nui i nā subtypes lysosome e like me nā trutosoms e ulu ana, e pili ana i nā mea kaumaha Hiki i nā noiʻi hou ke nānā aku i ka hoʻomohalaʻana i nā blurorescent a iʻole ke olaʻana i nā mea hana e aʻo ai i nā hana trutolmal i ka manawa maoli.

Hopena

Hōʻikeʻo Rat Trictosomes i kahi hoʻolālā kūikawā a me kaʻikeʻole e pāʻani ana i kahi hana koʻikoʻi ma ka blulogy mossosmal. Ma ka hoʻokauʻana a me ka mālamaʻana i kēia mau mea hana, ua hiki ke hana i ko lākouʻike o ka Hoʻolaha metabol, a me ka hana maʻi maʻi maʻi, a me nā maʻi maʻi maʻi.

Ke hoʻomau nei kaʻaha kūkāʻepekema eʻimi i nā invussies o ka hoʻonohonohoʻana o nā mea hana subcerollar