HoʻolaaʻaʻiaNā momi Kelepona
ʻO nā Microsomes liʻiliʻi he mau'āpana SCECECH liʻiliʻi i loaʻa mai i ka recoulum reclulum a loaʻa i loko o nā ceclulum a loaʻa i loko o nā cell cell (hepatocytes). Ke pāʻani nei lākou i kahi kūlana koʻikoʻi ma nā kaʻina hana biopemical e like me ka nui o ka lāʻau lapaʻau a me ka detoxification. Ka hoʻomaopopoʻana i keʻano, hana, a me keʻano nui o nā microsome no ka hoʻomaikaʻiʻana i ko lākou hopena i ka pharmacomy, a me ke olakino ola
Ka hoʻonohonohoʻana a me ka hoʻokumuʻana o Microsomes
● kahi i puka mai ai mai ka reculum o ka hope
Hoʻokomoʻia nā Microsomes i ka wā o ka homogennization a me ka heluʻokoʻa o ka cell cell Hiki i kēia kaʻina hana no ka hoʻokaʻawaleʻana o kēia mau hana subcerlular, nā mea waiwai i nā mea waiwai a pono no nā hana metabolina.
● composition a me morphology
ʻO nā microsomes Lifeoso ma mua o ka membrane - nā'ōwili e hoʻopaʻaʻia ana, nā lipids, a me nā proteins. Mālama lākou iā lākou e hoʻomaʻamaʻa i nā hopena biochemical, e komo pū me nā mea catalyzome p4onchome. ʻO nā hiʻohiʻona morphological o nā microsmes ka pivotal i ka hoʻoholoʻana i kā lākou mau hana hana i nā ala metabolic.
ʻO nā Microsomes a me nā Metabolism
● role ma detoxificalication
ʻO nā Micrososomes e pili ana i keʻano o ke kino e hoʻokaʻawale i nā mea hoʻohui likeʻole, me nā lāʻau lapaʻau a me nā mea hana kino. Hoʻopili kēia kaʻina hana detoxification i ka hoʻohuliʻana i nā mea lipophilic i loko o ka wai hou aku i loko o ka wai.
● cytochrome p450 equitme'ōnaehana
ʻO kekahi o nā mea waiwai nui loa i loko o nā microsimes olaʻo ke microsome ka cytochrome p450 (cyp). ʻO kēia mau enzymes ke kuleana no ka metabolism o ka pelekane o ka nui o nā mea i kauʻia, e pili ana i ka lāʻau lapaʻau, no laila ke pāʻani nei i ka lāʻau lapaʻau. Hiki i ka hana o kēia mau enzymes ke hoʻokō i ka hopena a me nā leʻaleʻa o nā lāʻau lapaʻau.
ʻO MicrosoMal Advymes a me kā lākou hana
● nāʻano o nā enzymes i hōʻikeʻia
Loaʻa nā microsome i nāʻano he nui o nā enzymes, e hui pū me nā inidies, nā hōʻemi, nā hoʻemi, a me nā hydrolases. ʻO kēlā me kēiaʻano enizyme kūikawā e hoʻomaʻamaʻa i ka hoʻomaʻamaʻaʻana i nāʻano biochemical, e hāʻawi ana i ka hana holoʻokoʻa o ka wai holoʻokoʻa.
● Nā Kūlana Kūʻai Kūʻai
ʻO nā enzymes i loko o nāʻano hasto texosme catilze i nāʻano likeʻole, e hōʻike ana i kaʻokoʻa, hoʻemi,ʻo ka hydrosia, a me ka conjugation. He mea pono kēia mau hana no ka biotransform o ka retogenous a me exogenous compounds, e hōʻoia ana i ko lākouʻike pūnaewele kūpono.
Role ma xenobiotic metabolism
● Wehe i nā mea'ē aʻe
ʻO Microsomes ka pivotal i nā metabolinizing xenobolit-mau mea haole e komo i ke kino, e like me nā lāʻau lapaʻau, a me nā mea kanu. Ma o kekahi mauʻano o nā reactions enzymatic, hoʻololi i kēia mau mea hōʻeha maikaʻi i nā mea hōʻeha i loko o nāʻano mea likeʻole.
● Aila i ka Pharmacocomen a me Tickiko
ʻO ka hiki ke ola i nā Microsomes i ka Metabolize Xenobiotics he nui nā hopena nui ma Pharmacology a me Toxicology. Ua kōkua kaʻike micropomal i ka hoʻolahaʻana i nā lāʻau lapaʻau, nā hopena kūpono, a me nāʻano hana pilikino i ka hoʻolālāʻana i ka lāʻau lapaʻau
Microsomes ma Lipid Metabolism
● synthesis o nā lipids
Ke pāʻani neiʻo Motos Microsomes i kahi kūlana koʻikoʻi ma Lipid metabolism, me ka synthesis o nā phospholiplids a me nā triglyriedides. ʻO nā mea lipids e pono ana he nui nā'āpana o nā membranes a me ka lawelaweʻana i nā moleki no ka mālamaʻana o Microsos i ka mālamaʻana iā Microsomes
● Role ma Cholesterol a me Stepbolism
Hoʻokomoʻia nā Microsomes i ka bosynthesisis a me ka hoʻoponoponoʻana o nā cholesterol a me nā hormone steroid. ʻO Enzyme i loko o nā Microsomes e hoʻoikaika i ka hoʻololiʻana o ka cholesterol i loko o nāʻano lāʻau lapaʻau a me nā mea hoʻonaninani a me ka ho'ōlaʻana.
Ka hoʻoponoponoʻana o ka hana microsual
● Nā kumuwaiwai e hoʻoulu ana i nā hana uila
Hiki i kekahi mau mea ke hana i ka hana o nā hana o MicrosoMial, me keʻano Genetic,ʻo keʻano, a me keʻano, a me ka hakakāʻana. Hoʻohui houʻia, nā mea kūʻokoʻa e like me ka meaʻai, ke nānāʻana i nā lāʻau lapaʻau e hiki ke hoʻololi i nā hana enzyme a me nā lāʻau lapaʻau holoʻokoʻa holoʻokoʻa.
● ka hopena o ka meaʻai a me ka ea
ʻO nā mea makeʻai a me nā mea aʻo kino e pāʻani i kahi koi koʻikoʻi ma ka hoʻopaʻaʻana i ka hana micos kāne. No kaʻoiaʻiʻo, hiki i kekahi mau meaʻai ke hoʻonāukiuki a iʻole i ka hanaʻana i ka hana o Cytochrome P450 Endittoms, e alakaʻi ana i nāʻano metabolism a me ka maikaʻi. Hiki i nā mea hoʻonaninani ke ola i ka hopena o ka microsual microsual
Nā hoʻololiʻana i nā micorological ma Microsomes
● hopena o nā maʻi o nā maʻi
ʻO nā maʻi ola e like me hepatitis, cirrhosis, a me nā maʻi momona momona hiki ke alakaʻi i ka hana ma MicrosoMe Hiki i kēia mau loli ke hōʻemi i ka hiki ke metabilize i nā lāʻau a me nā mea likeʻole, e hāʻawi ana i ka holomua o ka maʻi lihi.
● Hoʻololi ma muli o ka waiʻona a iʻole ka hōʻinoʻana i ka lāʻau lapaʻau
Hiki ke lilo i kaʻaiʻana o ka mea inuʻona a me ka hōʻinoʻana i ka hoʻomaʻamaʻaʻana i nā loli nui ma nā microsoms koʻikoʻi, me ka hoʻopaʻaʻana i ka enzyme a iʻole ka pahuʻana. Hiki i kēia mau mea hoʻololi ke pili i ka hiki i ke ola ke metabilize i nā mea waiwai
ʻO Microsomes i ka noiʻi a me nā diagnostics
● E hoʻohana i ke aʻoʻana i nā lāʻau lapaʻau lāʻau
Hoʻohanaʻia nā microsome i ka noiʻi preclinical e aʻo i nā'ōnaehana lāʻau a wānana i nā ala metabolic. Hoʻohana nā poʻe noiʻi i nā microsome i nā microsome e loiloi i ka pono o ka lāʻau lapaʻau, e hoʻoholo i kaʻikeʻana i ka metabolite no ka hoʻolālāʻana i ka lāʻau lapaʻau
● Nā noi i nā maʻi maʻi maʻi maʻi
I nā diagnostics Clinical, e lawelaweʻo Mobososmes e like me kahi mea waiwai nui no ka loiloiʻana i nā hana ola metabolina. Hiki ke hoʻohanaʻo Diagnostic Sumeys i nā Microsomes Live Mobitome
Nāʻaoʻao e hiki mai ana a me nā malihini
●ʻO ke aʻoʻana ma Microsomal Information
ʻO ka noiʻiʻana o ka noiʻiʻana ma ke kulaʻo Microsomal Biology e hoʻomau e wehe i nāʻike hou a me ka hoʻoponoponoʻana i nā microsome. ʻO nā holomua ma Genomics, nā mea pale aku, a me nā metaboloks e hoʻonui ai i ko mākouʻike a me ka maʻiʻana i ke olakino a me nā maʻi lapaʻau
● Nā hana hoʻohālikelike e like me nā hālāwai kūkā e puka mai ana
Ke hoʻomohalaʻia nei nāʻenehana likeʻole a me nā merdodologies e hoʻomaikaʻi i ke aʻoʻana o nā MicrosomesMe. Kiʻekiʻe loa -ʻO ka hoʻopiliʻana i nā hana lapaʻau, holomua i nā hana hana, a me nā mea hana ikaika loa e hiki ai i ka hana a me nā mea hoʻonaninani o nā lāʻau lapaʻau hou.
E pili ana i ka Iphise
Heansquar i loko o North Wales, Pennsylvania, Iphoe ʻO nā biosciences he mea kūikawā, a me nā mea hou aku, a me keʻano hoʻohālikelike. ʻO kaʻike nuiʻana o kaʻike nui a me ka makemake no ka noiʻiʻepekema,ʻo kā mākou mea loeaʻepekemaʻoi aku ka hoʻokōʻana i nā mea loea i ka honua nei Ke alualu nei i ka R & D kūpono kūpono o nā "revnovative reving," nā mea kūʻai aku, a me nā wahi kūʻai aku ma mua
Nā manawa post: 2024 - 208 - 09 17:12:10