Hōʻikeʻike
ʻO nā cell he mea nui loa o ka'ōnaehana o ka impune ʻO ke kaʻina hana o ka hana o ke keleponaʻo ia he paʻakikī, nāʻano hana likeʻole e pili ana i nā hōʻailona helu helu a me nā hōʻailona bioxmical ʻO ka hoʻomaopopoʻana he mea nui kēia kaʻina hana no ka holomuaʻana o ka immunogragrapy a hoʻomohala i nā maʻi kūpono no nā maʻi e like me ka maʻi maʻi. Ma kēiaʻatikala, eʻimi mākou i nā'ōlelo'ē aʻe o nā hana hoʻohuleʻa o T e hoʻoulu nei, mai ka hōʻike Arialmentsing a me Reglationt cell activation kits.
Hōʻike aʻoaʻo a me ka mahalo
● Role o Antigen - Hōʻike i nā papa (APCS)
Antigen -ʻO nā mea e hōʻike ana i nā papa hana (APC) he mea nui loa i ka hoʻomakaʻana o ka hana hana. ʻO kēia mau helu kūikawā, e komo pū ana i nā cells dendritic, nā macrophages, a me nā cell Ke hele nei kēia hōʻike ma o ka mea nui o ka mea nui o ka wahine
● He nui konaʻano he nui (mhc)
ʻO ka pilina ma waena o MHC MOLC MOOLELO MA APCS a me T CENTERDETORST (TCRS) ma TRO CORNESSTOTYE o T CORNESTER. ʻO MHC papa i nā molcles i kēia manawa i kēia mau mea endogenous e cd8 + cytototo E hōʻoia i kēia kiko'ī kiko'ī e hiki ai i nā terll ke hoʻomaopopo pololei a pane i kahi ākea ākea o nā pathogens.
T cell resptor (tcr) hui
● keʻano a me ka hana o ka TCR
ʻO ka TE CENTE GETPORT (TCR) kahi kūlana SPECIX SPECUNX paʻakikī e loaʻa ma kaʻaoʻao o nā cell. E hoʻopili ana i nā kaulahao a me nā kaulahao a Beta ʻO kaʻano likeʻole i ka hana TCR eʻae no ka hoʻomaopopoʻana i kahi hui o kahi entigens.
● kiko'ī o kaʻike antigen
ʻO ka kiko'ī o nā TCRS e hoʻoholoʻia e ka hoʻonohonohoʻana o nā amino e pili ana i nā'āpana amino i loko o nā wahi likeʻole o nā'āpana o nā alpha a me nā kaulahao. ʻO kēia kiko'ī he mea nui no ka hopena o ka paneʻana o ka paneʻana, e like me ka mea e pono ai e hoʻokaʻawale i waena o keʻano pilikino a me nā ancoige paha. Ua hoʻolālāʻia ke kiʻekiʻe o ke Cell i nā hana hana hana maikaʻi e mālama i kēia kiko'ī i ka wā o nā kaʻina hoʻokolohua, e hāʻawi i nā hopena kūpono.
KāʻO - Nā hōʻailonaʻike Sous
● He nui o nā hōʻailona hōʻailona
ʻAʻole hilinaʻi maoli ka hana o ka cell ma keʻano he meaʻike antigen; Pono ke kekona, ce - Kāua - hōʻailona thimalay e hoʻomau ai. Pono kēia mau hōʻailona i ka hana pihaʻana i nā cell a pale aku i ka aergic (hikiʻole). ʻO ka haʻaleleʻana o CO - E hiki i nā hōʻailona Stumulatory ke alakaʻi i ka alenunce impoune,ʻo ia ka mea nui no ka paleʻana i nā maʻi autoommune.
● Nā Molecules e pili ana
Co - Nā Molecules e like me CD28 ma TD CO CLLS a me B7 ma Apcs Play A APPT e hāʻawi ana i nā hōʻailona o ka cell. ʻO ka hoʻopiliʻana ma waena o CD28 a me B7 Hoʻolaha HoʻolahaʻO Vekess, ola, a me Cytokine Production. Nā kuʻekuʻe'ē aʻe i nā mollucales, e pili ana i ka ichas a me sex0, hoʻohui hou i ka hana a me nāʻokoʻa n? T CILD DECTERE HOOPONOPONO O KA PILI ANA E KOMOHE ANA E KOLOHE ANA I KE KOLOHE ANA I KE KUPUNAKA E PILI ANA I KA EXPET SMALT CLECUST.
Nā ala kaua hōʻailona
● Intracellular hōʻailona hōʻailona
I ka manawa o ka TCR a me CO -ʻO nā Moolecules e hana pū me kā lākou mau ligands i hoʻopaʻaʻia me nā hanana hōʻailona o nā hanana hōʻailona intracellular. ʻO kēia mau hōʻailona hōʻailona e komo i kahiʻano o nā hanana phosphorylation a me ka hanaʻana o nāʻano koloka o nāʻano likeʻole, e like me lck a me Zap - 70. ʻO kēia mau kahu i ka phosphoryleble i ka protein ma luna o nā pale adapter adap, e alakaʻi ana i nā ala he nui, me ka mania, nf - κ-ala.
● Nā Mālama Kūʻai a me nā enzymes e pili ana
ʻO nā protein e like me ka Lat ʻO nā enzyme e like me phospholipase c - γ (γ (plc - High - Ua hoʻohana pinepineʻia nā kiʻi kiʻi kiʻi kiʻi i kēia mau mea kūʻai aku a me nā enzymes e hōʻoia i ka hoʻololiʻana i nā hōʻike hoʻokolohua.
ʻO ka hana cytoxine a me ka pane
● hana o nā cytoxines i hanaʻia
Hoʻokomoʻia nā cell i hana i nā cytokines like me nā orchestate i ka paneʻana o ka immune. Ua loaʻa i kēia mau cytokines i nā interleuns (im - 2, il - 4), interforis nā mea (tyf - α). Loaʻa i kēlā me kēia cytokine i nā hana kūikawā, e like me ka hoʻolahaʻana i ka proplifetion stell, e hoʻonui i ka hana cytototox, a me ka hoʻoponoponoʻana.
● Role i t cell ka leʻaleʻa a me ka hoʻomaʻamaʻa
E pāʻaniʻo Cytokines i kahi hana pivotal i ka hoʻoholoʻana i ka hopena o nā cell tomet. No ka laʻana, IL - 2 He koʻikoʻi no ka Clonal Expansion Expansion of T Cells,ʻoiaiʻo Il - 12 e like me kaʻokoʻa o nā cell TH1. ʻO ka heleʻana o nā cytokines kūikawā e lilo ai i kahi cell e lilo i mea kōkua he mea kōkua iā ia ʻO nā mea hana hana e hanaʻia mai nā mea hana i hoʻolālāʻia e hoʻolālā pono i ka hana cytokine e hōʻoia i ka hana kiko'ī ma luna o nā hana hana a me nāʻokoʻa.
T cell leather
● Hoʻokumu o nā helu kelepona likeʻole
Ma hope o ka hanaʻana, TE CELLS iʻokoʻa i loko o nā'āpana likeʻole, kēlā me kēia me nā hana likeʻole. Hiki i nā CD4 + Helper T CELL e hiki ke hoʻokaʻawale i ka th1, th2, th2, a me nā cell), e pili ana i kēlā me kēia hui i nā role Nā'ōkuhi th1 i pili i ka cell - mediated inimunity, th2 cell i ka mumual immunity, th17 i loko o ka manimu.
● Nā Kūlana Kūlana o kēlā me kēia pūʻulu
ʻO ka hana kūikawā o ka hanaʻana o nā helu kelepona e hōʻoia i ka paneʻana o ka mea e pili ana i ka hale kūʻai likeʻole i nā pathogens'ē aʻe. Th1 cell e hana i ka inn. Γ a he mea pono no ka hakakāʻana i nā pathogens intracellular e like me nā maʻi a me kekahi mau bulteria. Th2 coma comput Dom - 4, IL Th17 cell secrete il - 17 a pili i nā maʻi maʻi a me nā maʻi autommune. Regulatory TR CET BET BECL DORE IL - 10 A TGF - β, mālama i ka home ISMUME AUTOTOATION. ʻO nā kinina hana i loko o ka hanaʻana i nā kits e hoʻoikaika ai i kaʻikeʻana a me ka loiloiʻana i kēia mau mea kūʻai aku, kōkuaʻana i ka noiʻiʻana i ka immuurology
ʻO ka hoʻonuiʻana i ka papa kuhikuhi a me keʻano hoʻomanaʻo
● Kaʻana o nā cells i hanaʻia
I ka loaʻaʻana o nā hōʻailona kiʻi kiʻi a me ka hoʻouluʻana o ke cytokine, hana i nā cell stell i lalo o ka propid rapid. ʻO kēia kaʻina hana,ʻikeʻia e like me ka hoʻonuiʻana o ka clonal, nā hopena i loko o ka lehulehu o nā cellor e hiki ai ke pane pololei i ka antivien. ʻO ka mea hoʻohālike e alakaʻiʻia e nā cytokines e like mel - 2, nā hōʻailona ma o ka il - 2 receptor e hoʻolaha i ka holomua o ke kelepona
● E hoʻomohala i nā cells hoʻomanaʻo
ʻO kahi hoʻolahaʻana o ka'ōnaehana o ka ADPUTIVIVE o ka'ōnaehanaʻo ia ka hoʻokumuʻana o nā cell o ka hoʻomanaʻoʻana, kahi e hāʻawi lōʻihi. Ma hope o ka hoʻomaʻemaʻeʻana o ka Patohogen, kekahi mau i hana i nā cell i hanaʻia e like me nā cell cell. ʻO kēia mau cell e hoʻomau i ke kino a hiki ke kau i kahi wikiwiki a me ka paneʻana i ka wikiwiki. ʻO ke kiʻekiʻe kiʻekiʻe - Nā kiʻi kiʻi kiʻi maikaʻi loa i ke aʻoʻana i nā mea hana ma lalo o keʻano hoʻomanaʻo o ka hoʻomanaʻoʻana a me ka mālama.
Ke hoʻoponoponoʻana o ka hana hana t cell
● Ochanisms of immune degulation Regulation
Ua hoʻopaʻa paʻaʻia ka hana o ka cell e nā mea nānā i nā mea nānā i nā mea e pale aku ai e pale i nā pane nui loa a me ka autommunity. ʻO nā mea nānā i nā ala i loko o nā ala i loko o nā alaloa e lawelawe ana e like me nā brakes ma keʻano o ka'ōnaehana. ʻO ka kī nui e pili ana i nā ctmu - 4 (cytotopyx t - lymphocyte - 1 (pd -
● Role o nā hōʻailona hoʻohālikelike (CTLA - 4, PD - 1, ATC.)
Ctla - 4 hoʻokūkū me CD28 no ka hoʻopaʻaʻana i B7 mau molena ma nā Apcs, e hāʻawi ana i nā hōʻailona hoʻohālikelike. PD - 1, ma luna o ka hoʻopaʻaʻana i kona mau LD - L1 a me PD - L2, e hoʻopau i ka hana cettokine. ʻO kēia mau hōʻailona hōʻailona he mea nui no ka mālamaʻana i ka hanaʻana i ka IMMUNE a me ka paleʻana i ka autoimmunity. T cell hana hana i hāʻawiʻia eIphoeʻO nā BIOSCIENCES e hoʻohui i nā mea e aʻo ai i kēia mau ala ala, e hāʻawi ana i nā meaʻike i loko o ka model modumun a me nā mea i loaʻa i nā mea i loko o ka impoune.
Nā'ōlelo lapaʻau olakino a me nā palapala noi
● nā hopena no ka autoimmunity a me ka maʻi kanesa
Hiki i nā Aberrations i ka hana hana e hiki ke alakaʻi i nā maʻi autoimmune, kahi o ke kiʻiʻana o ke olakino maikaʻi. Hikiʻole,ʻaʻole hiki i ka hopena o ke kelepona hiki ke hopena i ka hanaʻana i ka fofromised ʻO ka hoʻomaopopoʻana i nā intricacies o ka hana hana o ka cell he mau mea hoʻonaninani nui, nā mea e hāʻawi ai i nā mea kōkua no ka hoʻomohalaʻana i nā mea i hoʻololi i nā mea kōkua
● Strapetutic Strategies e kuhikuhi ana i ka ho'ōlaʻana
ʻO nā hoʻolālā Trapeutitic Strateing e pili ana i ka ho'ōlaʻana o ka hana i nā mea nānā i nā mea i loko o nā hōʻailona o nā hōʻailona i loko o nā hōʻailona. Kālepaʻo Car - Ua hōʻikeʻia kēia mau mea hana i ka pōmaikaʻi i ka hoʻomaikaʻiʻana i kekahi mau mea hiki. Hoʻohui houʻia, nā hoʻolālā e hoʻokomo i ka induce impoune eʻimiʻia no nā maʻi autommune. Kiʻekiʻe loa - Loaʻa nā mea hana hana maikaʻi mai nā mea hana e alakaʻi ana i nā mea hana e pono ai nā mea hana a me ka ho'āʻoʻana i kēia mau mea mālama moʻolelo.
E pili ana i nā biosciences Iphise
Heansquar i loko o North Wales, Pennsylvania,ʻo IPHOVATE BIOSCUND, FORMERATRORGRON REGONGRESS. ʻO kaʻike nuiʻana o kaʻike nui a me ka makemake no ka noiʻiʻepekema,ʻo kā mākou mea loeaʻepekemaʻoi aku ka hoʻokōʻana i nā mea loea i ka honua nei Ke alualu nei i ka R & D kūpono kūpono o nā "revnovative revings, e kau ana i nā'āina'ē aʻe, a me nā wahi kūʻai aku, a me nā wahi kūʻai aku ma mua o 12,000 mau wahi kūʻai.
Nā Kūlana: 2024 - 202 - 25:40:30