Humanum periphericis sanguis Mononuclear Cell (PBMC)
PBMC potest mimic in - Vivo environment providere an efficens in - vitro exemplar ad medicamento development. Studeo effectis pharmaca in peltas et signalling meatus pbmcs potest adiuvaret in Discovering novi pharmacum peltas, et haec inventa potest providere unapcedent ideas et directiones ad medicamento inventa et progressionem.
Pelagus applicationem directiones PBMC in immunotherapeutic medicamento progressionem includit:
1.Antibody - dependens cell - Mediated cytotoxicity (adcc) PBMC ludit a key munus in Adc; NK cellulis, macrophaghages, etc, sunt pelagus effectrix pbmcs in Adcc actio. Hi cellulis potest occidere scopum cellulis encapsulated ab antibodies per binding illis.
2.Mixed Lymphocyte reactionem (MLR) A Co - Culture System ad Primary DC cellulis et T cellulis quod potest esse ad aestimandas DC - Mediabantur T cellula activation. DC cellulas exprimere magnas de PD - l1 in superficiem, quod potest ligare et inhibere PD - I super superficiem T cellulis. Si medicamento potest efficaciter angustos in reactionem via inter duo, tunc potest incitare proliferation de T cellulis et sic cognoscere operationem actionem medicamento.
3.T cellula activation assays: T cellula activation assays sunt unus ex communiter assisys ad perpendendis effectus immunotherapy medicinae. In T cellula activation assays, in - vitro excultus T cellulis sunt plerumque usus et opportunitate stimuli, ut antigens vel antibodies, sunt data inducere ad activation of T cellulis.
4.T cellula Expressionis Asay: T cellula proliferation Asay potest esse in protegendo immunotherapy medicamento candidati et aestimandis efficaciam de medicamento per comparationem ad gradum T cellula multiplicatione in diversis medicamento - tractata experimentum coetibus cum potestate coetus.
Humanum PBMCS produci ab Iphase sunt separatim a humano periphericis sanguine per densitatem gradientis centrifugaci. Hi sunt unum nucleus cellulis maxime composito ex lymphocytes (T cellulis, B cellulis et NK cellulis) et Monocytes.
▞ Product Information:
|
Nomen |
Item No. |
Specificatio |
Cellula status |
Storage / Shipment |
|
Humanum periphericis sanguis Mononuclear Cell |
082A01.11 |
V decies cellulis / ml |
Recens |
II - 8˚c repono, glacies Pack Shipment |
▞ Product Application:
In - vitro metabolism studio medicinae.
