Iecur S9 fraction: Efficens in medicamento Inventionis & S9 metabolicae stabilitas

Key verba:liver S9 fraction, hepatic S9 fraction, intestinal S9 fraction, lung S9 fraction, kidney S9 fraction, skin S9 fraction, human liver S9 fraction, monkey liver S9 fraction, beagle dog liver S9 fraction, rat liver S9 fraction, mouse liver S9 fraction, ADME, in vitro drug metabolism, liver S9 stability，S9 metabolic stability, FRAGMENTUM

I Iphase Products

II in vitro medicamento metabolismi stabilitatem studio

In Vitro Metabolic Stabilitate Research refers to testing in Biotransformation rate of componit in biologicum matrices ut iecur microsomes, S9, et iecoris cellulis, ut reflectunt facultatem PK de componit in vivo et diemAdme, consequi mane altum - throughput protegendo de componit et praedicere humana alvi rate. Secundum FDA ordinationes,In vitro medicamento metabolismStudies eget in usum recombinant expressio humana iecur microsomes (HLM), Human Humpi cellulis (recens aut gelida) et cytochrome p450 enzymes (in vitro) ad determinare humana metabolicae semita.

III iecoris S9 fraction / Hepaticum S9 Fraction

Iniecur s9 fraction (Hepaticum S9 Fraction)Est mitochondria libero supernatant de iecoris parenchymal cellula homogenate, quibus magna numerus of cyps et alia medicamento metabolizing enzymes. Est valde utilis Research tool pro studeo ad medicamento metabolismi de componit et investigandis potentiale medicamento - medicamento interactiones. Est etiam quod est momenti Reagent ad toxicological iudicium de mutagenicity probat (Ames) et chromosomal aberrationes probat (CA) in medicamentis, cibum, stibio, alchimicis, pesticides et aliis agris. In metabolicae stabilitas probat, iecoris S9 est maxime in his locis:

Inheret alvi rate: Hoc est momenti indicator ad aestimandis metabolicae enzyme operatio in iecore S9 apparatu. Exempli gratia, in humano corpore, in intrinsic alvi rate of iecoris S9 est circa DCXXXIV, significans quod iecur S9 habet efficient metabolicae facultatem.

Hetabolite Lepidium sativum: iecoris S9 praeparatio potest metabolize variis compositorum et generate diversis metabolitarum. Quod idem ex his metabolites est crucial ad intellegendum metabolicae semita et potentiale actiones de medicinae.

Metabolicae phenotype Research: De metabolis stabilitas medicinae, comprehendo eorum metabolicae rate et possibile medicamento interactiones, potest studied per iecur S9 Praeparata.

IV intestinorum S9 fraction

Intestinorum S9 est subcellular component /FRAGMENTUMParatus ab intestinorum TEXTUS, quibus abundat medicamento metabolizing enzymes (ut CYP3A4, UGT, Sult) et onerariis proteins. Est maxime ad studere ad primum - transire metabolismi oralis medicinae et synergistic effectus intestinorum effusio metabolismi. Et applications includit aestimandis biotransformation medicamentorum in ventrem (ut sulfation aut glucuronidation), praenuntiantur oralis bioavailability, et identifying conlationem de ventrem propria metabolicae enzymes (ut Sult1b1).

V Alia intestinorum fraction

Pulmonis S9, renibus S9 et cutis S9 sunt ex correspondentes textuum et ad studere loci metabolism et target organum toxicity.

Pulmonis S9 fraction: Quibus CYP1A1 / II, propter metabolicae aestimationem et haustus medicinae vel environmental pollutants;

Renibus S9 fraction(Renal S9 fraction) continet UGT et Sult, aestimandis medicamento renalis alvi et generatio nephrotoxic metabolitarum;

Cutis S9 FRACT: Studere in metabolicae stabilitas transdermal medicinae et activation cutis enzymes (ut Sult1e1).

Haec S9 components supplementum limitations de iecoris metabolicae notitia per simulantes TEXTUS - specifica metabolicae environments.

VI diversis speciei iecoris S9 fraction

In metabolicae activation ratio in geneticae toxicity testing est a mixta solutio iecoris S9 et cofachetrs paratus ex animali iecoris post medicamento inductione. In praesenti, differentias in metabolicae stabilitatem et metabolite profiles in diversis speciebus sunt maxime comparari per vitro incubitu systems ut iecur microsomes, iecoris cellulis, iecoris S9 et Plasma. Rodent speciei et non - Rodent speciei, qui habent closest metabolicae mores ad homines sunt electus. Ergo in Lorem experimentalem materiae ad iecur S9, maxime communia includitHumanum iecur S9 fraction, Monkey iecur S9 fraction, beagle Canis iecur S9 fraction, rat iecoris S9 fraction:etMuris iecur S9 fraction

VII conclusioni

Et S9 components (including iecur S9, intestinum S9, pulmonis S9, renibus et cutis S9) sunt momenti instrumentis in Vitro medicamento et metabolis progressionem per alium fibras. Iecur S9, cum suis dives metabolicae enzymes ut CYPS et deformis, late adhibetur ad intrinsec alvi rate determinationem, metabolite idem, et medicamento commercio investigationis; Intestinorum S9 focuses in primo transeat metabolismi et effusio metabolis Synergy oralis medicinae; Et pulmonis S9, renibus S9, et cutis S9 potest evaluate target organum specifica metabolismi et toxicity, implens limitations de iecoris metabolismi exempla monstrabit. Insuper, Disputatio Studies per speciei S9 (utHumanum iecur S9 fraction, Simia S9 fraction, beagle canis S9 fraction, rat S9 fraction et mus S9 fraction) potest auxilium eligere optimum exemplar ad preclinical experimenta et augendae valorem de notitia transformationem.