Maualuga hepatocytes vs. faʻamalolo hepatocytes: O 'eseʻese o le tele o faʻaupuga ma talosaga i vailaʻau suʻega

I. Folasaga

I le vailaau o le vailaau ma o loʻo faʻamamaina ai suʻesuʻega, Hepaotocytes e taua se vaega taua i le iloiloina o metotia fou. Ia i latou,maualuga hepaotacytes ma leTaofia le Hepatocytes Auauna atu ia galuega eseese, faia le filifiliga i le va oi latou e taua tele mo le sao i Vatro Suesuega. Malamalama i eseesega i o latou uiga ma talosaga e mafai ona fesoasoani ia tagata suʻesuʻe e filifili le sili ona talafeagai mo a latou manaʻoga faʻapitoa.

Ua ou le fiafia, o se taʻitaʻi i le Red Reloractic Regmages, Lagolagoina o le faasaienisi alualu i luma e ala i le saunia o le maualuga - tulaga lelei hepatocytes mo suʻesuʻega o suʻega. Faatasi ai ma tomai i le sela - faʻavae e faʻatatau i suʻesuʻega ma metabolism suʻesuʻega, e faʻamautinoa e le matou vaega o tagata suʻesuʻe i le lalolagi atoa

O lenei talaʻaga e lamatia ai eseesega o le va o le mautu ma faʻamalolo hepatocytes, oa latou tusi faʻapitoa i suʻega o vailaʻau, ma le auala e filifili ai le ituaiga saʻo mo lau suʻesuʻega.

Ii. O a ni mea ua tupu i le hepatoy?

O HAPATAED HEPATOCALYSSS o 'olo o' olo o loʻo i ai le agavaʻa e faʻapipiʻi ai i luga ma foliga monolayers, faia lelei mo le umi o le 3 suʻesuʻe.

Uiga Uiga:

• Mafai ona tausisi i le aganuu papatusi

Tausisi i le ate - galuega faapitoa i taimi uumi

Fetaui lelei mo le suʻesuʻeina o le EnzyMe o loʻo agaʻi atu, oona, ma feʻaveaʻiga gaioiga

Talosaga i le Tala Faatatau Fualaau:

• Le umi - Mamao Vailaau Metabolism suesuega:Faaaogaina e iloilo pe faʻafefea ona gaosia vailaʻau i le taimi.

• Enzyme faatosina suesuega:Iloilo le auala e aʻafia ai le faʻagaioiga a le atunuʻu

• Hepatotoxication screent:Faailoaina o malosiaga malosi mafua mai i nofoaga fou.

• GALUEGA GALUEGA GALUEGA:Suesueina o fualaau 'Vailaau - Fualaʻau Fesoʻotaʻi ma HEPATIC Uptake / Effewax Mechanasms.

III. O le a le tulaga o le hepatoone?

O le faʻamalolo o HAPAFacytes e le o - Andherent Lifer Clalls na faʻaaogaina muamua mo sina taimi puʻupuʻu - Taimi Metabolin ma le oona oona. Latou te taofia le aoga e maua ai, ae aua le faʻapipiʻi i le aganuu papatusi, e aoga tele mo latou suʻesuʻega tele.

Uiga Uiga:

• Non - Faʻatasiga, tausia i se tulaga faʻamalolo

• Lelei tele mo le puʻupuʻu - Faʻatulaga vailaau metabolis

• Tuʻuina atu le faʻatuatuaina o le vaega o aʻu ma le Pleasa II enzyme gaioiga faʻamatalaga
  
  

Talosaga i le Tala Faatatau Fualaau:

• Puʻupuʻu - Faʻatulagaina o vailaʻau metabolism suʻesuʻega:Fuaina o vailaʻau kiliaina tau.

• Maualuga - Add staption (hts):Vave faʻataʻitaʻiina le tele o faʻavae mo metabolic mautu.

• Tali atu Phenotyping:Faailoaina auala enzyme e aofia ai i vailaau metabolism.

• Fualaʻau - Fualaʻau Fuafuaga Suesuega:Iloilo tauvaga tauvaga metabolism ma enzyme le mafai ona vaaia.

Iv. Manatu Sili o le Iunaite Setete ma le faʻamalolo

O nei eseesega ia taualuga le taua o le filifilia o le talafeagai hepatiticyte ituaiga e faʻavae i luga o faʻamoemoe faʻamoemoe.

V. Talosaga i le Fualaʻau Suʻega ma Suʻesuʻega

Uma le lelei ma le faʻamaloloina o le hepaotacytes lautele faʻaaogaina i totonu o le vailaʻau ma vailaʻau oona. Malamalama lelei a latou apalai e mautinoa ai le faʻataʻitaʻiga faʻataʻitaʻiga mamanu.

2. Fualaau faasaina metabolism ma pharmacokinisics (dmpk):

• Faʻatulagaina HEPATOCALYSTER FOLAFOLAINA PO O LE MULIMULI MITABOCOCOCOCCE Stull.

• Faʻamalolo O HAPATOYSESESE E mafai ai e Raatod iloiloga o auala metabolic phoways.
  
  

Oona ma hepatotoxixictication screent:

• Ua fesoasoani Hetepeable hepatocytes e iloa ai le sili atu o le taimi nei - faaosofia le afaina o le ola (dili).

• Faʻamalolo o HEPATOYSERS e iloiloina Actate Sortotoxicty ma metabolic uiga.
  
  

O le Phase I & Sina IB metabolism suesuega:

• O le vaega na ou tali atu (oxideation, faʻaitiitia) e faʻaaogaina lelei faʻaaogaina uma ituaiga uma.

• E masani ona manaʻomia e le Stese II Convencugations (GLUCRUCRUSING, SLALFATID) e masani ona manaʻomia hepatocytes.
  
  

Faaosofia ma le naunau i suesuega:

• O le Horteeable hepatocytes e taua tele mo Typ Enzzyme Transduction Suesuega.

• Faʻamalolo O HAPAFOCALYS e maua ai faʻaaliga vave i le Enzyme o le taofia.
  
  

Maualuga - i le faʻaaogaina o vailaʻau

• Faʻamalolo atu o HAPAFAcytes e faʻafaigofie - fua le faʻavaeina o suʻega.

• O loʻo fesoasoani hepatored hepatocytes i ni auiliiliga o faʻafitauli.

VI. Auala e Filifili ai le Mea Tonu HEPATocyte Ituaiga mo Lau Suesuega

Ina ua filifilia HEPATOCALCYSERS MO SUʻESUʻEGA, tele itu e tatau ona iloiloina:

Suesue le umi:

• O le taimi umi - O le taimi o faʻataʻitaʻiga e manaʻomia ai le maualuga o hepatocytes.

• Ipu puupuu - Taimi Metabolism Anceys alofa Stipepen HEPATOCALYSTS.
  
  

Sini o sini:

• Faʻatosinaga, oona, ma tagata femalagaʻi suʻesuʻega:Maualuga hepatoytes.

• Metabolism scoung ma le taofi o le faamasinoga:Faʻamalolo HeaToniacytes.
  
  

Pepa Filifilia:

• Tagata hepatuacytesmo le fetaui lelei.

• Manu hepatocytesmo suesuega muamua.
  
  

Fou Vs. Smaopresered hepatocytes:

• Fou hepatocytesTausilia le sili atu le malamalama ae ua faʻatapulaʻaina avanoa.

• Croplopresered hepatocytesofo atu le faigofie ma toe gaosia.
  
  

Ua ou maua le leai o se mea maualuga - lelei le lelei ma le faʻamalieina hepatocytes mo suʻesuʻega talosaga. O a matou tagata atamamai e mautinoa e maua ai e saienitisi ma faʻamaonia le toe faʻaaogaina o le vailaʻau

Vii. Faaiuga

Malamalama i eseesega i le va o Headuta, HEPATEACYSETERSEES O HAPAFACALYS e taua mo le filifilia o le sili sili ona lelei faʻataʻitaʻiga ma vailaʻau oona. O le maualuga o hepatocytes Excel i le taimi umi - o le faʻataʻitaʻiga faʻataʻitaʻiga, aʻo le faʻamalolo hApatocytes e lelei tele mo le tele o cantaiblim.

Ua ou le fiafia i ai, o se tagata tautua o se tagata faʻatuatuaina o tagata fou o le ola o le tino, e ofo atu le maualuga - Tulaga lelei hepatocyte fofo e alualu i luma o le suavai. Faatasi ai ma le sili R & D agavaʻa ma se vaega o loʻo avea ma vaega o le lalolagi, matou te mautinoa o saienitisi e mafai ona maua ni faʻataʻitaʻiga hepaota mo le tipiina -

Mo nisi faʻamatalaga i le filifilia o le taumatau hepatocytes mo lau suʻesuʻega, asiasi i ai biossamentations aso nei.