Ua i ai le biosses
Microsomes o loʻo maua ai le vaega o loʻo maua mai i le Orioplasmic of Desicoulum o sela, muamua hepatocytes (o le a o sela o le hepatocy). E latou te mauoa i vailaʻau - metaboling Enzymes, masen o le Cytochrome P450 (Cyp) aiga, e taua le sao o le okeatitatives o le okarative o le tele o lotoa. Metabolic Malosiaga e faʻatatau i le faʻaaogaina o Microsomes e tuʻufaʻatasia i le amataga o le vailaau o le tele o atinaʻe aua latou te fesoasoani i le vivo pharmacokinetics. I le fuaina o le fua faatatau o metabolism i vitro, tagata suʻesuʻe mafai ona fuafuaina le afaina ai o le mea e maua ai le mea e maua e se vailaʻau. O aso na e le naʻo le faʻafaigofieina o le siakiina o le tele o le tele o faʻavae i se auala maualuga - e le o loʻo i ai foi le faʻamatalaga o le metabolic metotia. O le tuʻufaʻatasiga o Microsomes mai Ituaiga eseese ua faʻatagaina mo se malamalamaaga atoa o le hepatic ma le sili atu metabolic metabolic, o loʻo taua mo le faʻamalosiina o vailaʻau. Le masani masani microsomes imetabolism mautuAsuy e aofia ai:Ola Microsome, Actine Micromeme / Ava Micromenas Microsome, Lung Microsome Microsome.
Ola microsomes
Ola microsomese sili ona tamaoaiga i cytochrome p450 enzonmes ma e fesoʻotaʻi oxidoredourestics. O a latou mea taua e maua ai le mea e maua ai le afā o loʻo faia ai le tele o Microsom. I le taimi o se Assay, o se sui tauva o loʻo faʻamauina i totonu o le ola mama i luma o se tagata taua e pei o nadph, ma le fua o le matua o le metabloazed i le taimi. O faʻamatalaga na maua mai i nei faʻataʻitaʻiga o loʻo faʻaogaina e fuafua ai le le-kisaliina, o se mea taua e fesoasoani e mafai ona vavalo pe o le a le vave tapeina o se vailaʻau. Ona e mafai ona faʻaseʻe Microso Microsomes mai le tele o suʻesuʻega, latou te maua ai se talitonuina ma toe gaosia faiga e faʻaititia ai le fesuisuiai i totonu o tagata.
Actimel Microsomes / Actiptine Microsomes
Actimenal Microsome, o isi taimi e iloa foi oFaasaoina Micromeme, e ui lava e itiiti tele i le metabolic enzolicsmessima faʻatusa i a latou stpatic couports, e tutusa lava le taua i le faʻasologa o muamua - pasi metabolism. I tua o Taufiaga Tau Faʻalauiloa, o se vailaʻau e tatau ona ui atu i le tino o le tino e ono faia ai ni suiga taua aʻo leʻi oʻo i le sologa lelei. O le metabolic gaioiga i totonu o le manava gaʻo e mafai ona aʻafia tele ai se mea sese, ma ua maua mai faʻamaumauga mai nei taimi e atiaʻe ai fuafuaga muamua
Pam Microsomes
Efuefu microsomesua saunia mai le paʻu o le paʻu ma le faʻaalia o vailaʻau - metabolizing gaioiga, aofia ai ma i latou o lip enzymes. A o le mea faʻapitoa e maua ai le paʻu i le paʻu e masani ona i lalo ifo o le 10% o lena mea ua maua i totonu o le ate, e taua tele le paʻu o le biotralmal. Faʻaaogaina le paʻu paʻu o le paʻu i taimi e mafai ai ona maua ni malamalamaaga i le metabolism o faʻamau o loʻo faʻaaogaina lelei pe faʻaaogaina le paʻu.
MāmāMicrosomes
Mama microsomesua saunia mai i le purmonary tissue ma ua faʻaaogaina e suʻesuʻe ai le metabolism o faʻapipiʻi o loʻo faʻatautaia e ala i le manava poʻo le faia o latou aʻafiaga i totonu o le manava. A o le le mafaufau o Cytochrome P450 Nengzy i lalo ifo o le i lalo ifo o le ate, o le mama mama o loʻo tumau pea o le nofoaga o le siosiomaga ma vailaʻau. O lenei faʻataʻitaʻiga e sili ona taua i le iloiloina o tissie - faʻapitoa metabolic suiga ma ono mafai ona afaina i le lotoifale.
Greenney Microsomes
Greenney Microsomeso loʻo tuʻu ese mai i tua atu o tisu ma tuʻuina atu malamalamaaga i le metabolic gaioiga e tupu i le fatuga. Talu ai o le fatugaʻo e le gata o se okeni o le tuʻufua ae o le tasi foi e sao i le metabolic kilia o ni vailaʻau, o le faʻaaogaina o le faʻasologa o metabolites e mafai ona fesoʻotaʻi ma le faʻasaoina o le metabolites e mafai ona fesoʻotaʻi i totonu o metabolites e mafai ona fesoʻotaʻi i le astabotites. I lenei auala, o Midney Microsomes Faʻatumuina faʻamaumauga mai le Aster ma Inteptional Sforts, tuʻuina atu se ata lautele i luga o le compolic propolic propolic data.
Thodis Microsomes
Molimau microsomese maua mai i le tisfoular tisu ma aofia ai enzymes nafa ma le metaboling bacougenast ma exogenos compounds. A o le masani ona faʻaaogaina nai lo 'olo palapala, e mafai ona latou talafeagai i le suʻesuʻeina o le metabolism o mea e aʻafia ai le soifua maloloina. O faʻamatalaga patino i latou faʻaaogaina i metabolic Mandable o loʻo faʻatapulaʻaina ma e ono eseese e faʻatatau i le faʻatonuga.
Bididymis Microsomes
Onodidymismis microsomesua maua mai le epididymal tissue ma, pei o le Midis Microsoms, e aʻafia i le metabolism o nisi o faʻatusatusa. O a latou tusi talosaga i Metabolic Matracraction Jouystey e le masani ai, ae mafai ona faʻaaogaina i suʻesuʻega o loʻo suʻesuʻeina le metabolism o le aafiaga o le mafaufau ma toe gaosia. O auiliiliga faʻataʻitaʻiga ma le faʻaaogaina o le a faʻalagolago i sini faʻapitoa o le suʻesuʻega.
O le vaega o Metabolism & Nadph Regeneration system
O le vaega lea sa ou talitae sili atu le aveina e le cyp enzymes, ma nei tali e manaʻomia se sapalai faifai pea o le faʻaititia o le faʻaititia tutusa i foliga o Nadph. Ina ia mautinoa o le Nadph o loʻo avanoa i le taimi o le Invebation vaitaimi, aNadph Redeneration systemua faaopoopo i le metay. LeNadph Redeneration systemE masani ona aofia ai nudp⁺, glucose - 6 - phosphate, ma le enzyme glucose - 6 - phosphate dehydromata, o le a le faʻaauau i tua i le nadph. O lenei toe faʻaleleia e taua ona o loʻo lagolagoina le toe faʻaleleia o le Redox Roaszed e le Cyp Enzymes, faʻatagaina le Microsomes e faʻatumauina ai a latou metabolic gaioiga i taimi uumi.
Fig 1. Vaega ou te tali atu i le ala i fualaau faasaina metabolism
O le ARAGE II metabolism & Ugt Insubaution system
A o le ola gired Microsomes e masani ona fesoʻotaʻi maO le vaega o Metabolism, e mafai foi ona fetuunai e suesueE tali atu le APA IPpei o le kulusini. Gilucronsivetion o se conjugrive gaioiga mafai ona fetuutuunai e urdidine 5 '- daphospho - GLOCARCOMSYTTERFEFECECE (UGT) o le faʻapipiʻiina o fualaau' aina. Ina ia faafaigofieina glucrondition i se microsomal metay, aUgt Beabution SystemFaatasi ai ma le cofactored cofactor udp - gluccinic acid (Udpga) faaopoopo. O le Ugt Insubation System e masani ona aofia ai UDPGA, Porotini o Procymidin ma D - GLOCARCRYLL - 1.4 - Lactone. Talu ai o le UGTT enzymes o Membrane - noataga ma atonu e le mafai ona le mafai ona maua i le malosi micromeme, o se pore - fausia o le sooupu e pei ona aofia ai i nisi taimi e aofia ai. Alamethin faʻateleina le permepale o le Microsomal Mymbranes, o loʻo i ai nei le ulufale atu i le UDPGA i le UDPGA i le le lelei o le GLACRONDINDE.
Fig 2. O le tali atu ma mea lelei o le phase iis fualaau o metabolism.
BEFER System
Uma le faagasologa atoa, o le0.1m PBSBuffer o se mea taua tele i le faʻatumauina o le mautu ma gaioiga o le enzymes. O lenei pepa buffer e maua ai se mea lelei o le PH ma le mafai ona taua tele, e taua tele mo le faʻasaoina o le faʻatulagaina o le faʻamasinoga o le Cyp ma UGDEmes. O tulaga e masani ona faia e le 0.1M PB e faʻamautinoaina o le uiga o loʻo tupu i se faiga faʻatonutonu, faʻafaigofieina le fua o le metaboling fua ma kilia.
Eseese ituaiga microsomes
Tagata microsome
Tagata Microsomese talafeagai le sili ona talafeagai i le metabolic mautu e faʻatatau i le vailaau o le vailaʻau Tagata Atinae Microsomes aofia ai se maualuga maualuga o cytochrome P450 enzymes, e nafa ma le Vaega I Metabolism o le tele o fualaau. O nei microsomes e matua faʻaoga tele e iloilo ai vailaʻau a le tagata, e aofia ai ma le enszyme o fegalegaleaiga fegalegaleaiga, caubolics le tumau, ma le faʻailoaina o le ono oona oona. O latou faʻaaogaina e taua i le amataga o - vaega fualaau faasaina e mautinoa ai o le a lelei le parmoshokinis i tagata, ma le mata i le aloese mai le aloese mai le 'aiga leaga.
Non - Tagata Portates Liver Microsomes
Non - Tagata Taua Muamua Microsomes, masaniRishaus Monkey Afrr Microsomes Microsoms Monkey Cory Microsomes, po o Cynomoligus manukiOla Microsomes, o loʻo faʻaaogaina i metabolism mautu e faʻatatau i le iloiloga pe faʻafefea e le pule o metablized e enzymes i le ate. O nei microsomes o loʻo i ai Cytochrome P450 Enzonmes ma isi metabolic Post i le faʻafaigofieina o le Presebolism. E le taua i le tagata muamua i mataupu taua i suʻesuʻega talafeagai aua o le latou fatu enner e pei o le mea taua o tagata mo le iloiloina o sui o le vailaau. Latou tuuina atu nisi faʻamatalaga talafeagai i luga o le tagata - pei o metabolism faʻatusatusa i rodents, faʻaleleia le saʻo o vailaʻau o vailaʻau
Taifau ola micromesoso
Maile, aemaise tele maile maile, e masani ona faʻaaogaina i le oona ma le pharmacokinetic suesuega.Taifau ola microsomes, aemaise i latou e maua mai ia WEM, aoga meafaigaluega mo le malamalama pe faʻapefea ona faʻaaogaina se vailaʻau i se vailaau.Canine Listr MicrosomesE masani ona faʻaogaina i le fomaʻi o le saogalemu o le saogalemu e iloilo ai le le tumau o metabolic mautu ma le mafai mo vailaʻau o vailaʻau. O nei microsomes e mafai foi ona faʻaalia ai le oona o le a faʻamaloloina ma faʻagaioia i tagata, saunia manatu i le tele o faʻafitauli i le va o le metabolism.
Rat ola micromeme
O isumu o se tasi o le sili ona lautele faʻaaogaina o manu feololo mo le vailaʻau ma vailaʻau oona, ma o latou o lotoa micromes e taua tele i metabolige tumau i metabolic malosi i metabolic malosi i le metabolic tumau i metabolic malosi i metabolic malosi i le metabolic tumau i le metabolic tumau i le metabolic tumau i le metabolic tumau i metabolic.Ratt Liver Microsomese masani ona faʻaaogaina i le amataga o le - Praccess Pisinisi atinaʻe e iloilo ai le metabolism o faʻataʻitaʻiga faʻavae, e pei ona malamalama lelei o latou faʻagaioiga o le metabolic. E ui lava o Rats faʻasoa mai le tele o auala metabolicking ma tagata, e le mafai ona iloga ese o ni gaioiga Rat Microsomes e masani ona faʻaaogaina e faʻataʻitaʻi ai se vaega lautele o le metabolic malosi ma e iloilo faʻafitauli pharmocokinic, pei o le kilia.
Mose masel rum micromeso
E tutusa foʻi ma isumu, o loʻo faʻaogaina faʻavao atu e isumu i Bidio Anaddamedical Suʻesuʻega, ma Moch Microsom taʻalo i Metabolin Tumau alofa O isumu e taua tele mo le suʻesuʻeina o le General Voisitions i le Vailaau Metabolism ona o le latou lelei - faamatalaina manatu.Isumu ola microsomesaofia ai le tele o cytochrome p450 enzym, e aoga ai mo le iloiloina pe faʻafefea ona faʻaaogaina se vailaʻau i luga o le fua o augatupulaga. O se ituʻi o le isumu, balb / c nude, ua taʻua o se mafatiaga e leai se mea e te le lelei ai. I le faaaogainaBalb / C Nude Listr Microsomes, e mafai ona iloiloina e tagata suʻesuʻe le auala e mafai ai se vailaʻau poʻo le tulafono, o le faʻavaeina o lona mitoratone, ma lona ono ono malosi i le 'eseʻese a tagata. Ae ui i lea, o Mouce ua i ai ni metotia iloga metapolicalicaways sa faatusatusa i tagata, o lona uiga o faʻamatalaga mai le isumu Microsomes e tatau ona faʻauiga ma le faʻaeteete pe a valoia metabolism. O le isumu Microsomes e masani ona faʻaaogaina i le maualuga - Cartat scrateding e iloilo ai le tele o le faʻapipiʻi vave.
Hamsters ola micromeme
Hamsters, aemaise lava le auro Surmin Hamsters, e masani ona faʻaaogaina i metabolic suesuega ona o latou tulaga ese o le tino.Hamsters ola microsomese aoga i le iloiloina o vailaʻau metabolism ma oona, aemaise lava mo tufuga e ono faʻaalia ai meaola laiti. O Hamster Microsomes e masani ona faʻaaogaina e suʻesuʻe pe faʻafefea ona mafai ona malamalama lelei i mea laiti i tamaʻi povi fatufatu i totonu o isi auala.
Gerbillinae Liver Microsomes
Gerbillinae Liver Microsomese maua mai i derbils, o se tamai amamal ituaiga masani masani ona faʻaaogaina i le oona ma vailaʻau oona. I metabolism Malosiaga Faʻamaoni, Gerbillinae Lio Microsomes e iloilo pe faʻapefea ona maua se faʻasologa o le Groosoma. O Carionence Constress e faʻailoa ai le metabolic mautu o fualaau faasaina poʻo vailaʻau, suʻesuʻe lo latou gafatia mo le biotranstation ma aveese. O tagata taʻalo o loʻo faʻaogaina i nisi taimi mo nei suʻesuʻega ona o a latou faʻamatalaga faʻapitoa metabolic, lea e mafai ona ofoina manatu i ituaiga - faʻapitoa eseesega i vailaʻau metabolism.
Minipig Liver Microsome
O loʻo maua e Minipigs le faʻateleina o le lauiloa i le Pharmacokinic Mayocoloclogy ona o le latou lava o le onosai i tagata, aemaise lava i tulaga o le oona metabolism.Minipig Borr Microsomese masani ona faʻaaogaina i metabolic mautu e faʻatatau i le saunia o faʻamatalaga e sili atu le tutusa o le metabolism faʻatusa faʻatusa i faʻataʻitaʻiga. O nei microsomes e matua aoga tele mo le suʻesuʻeina o fualaau faasaina, tufatufa, metabolism, ma le faʻauiga (ADME) i se faʻataʻitaʻiga o le tagata - pei o le sili atu o le tagata - pei o Metabolic Prompssion. O Millipig e taua tele i le iloiloina o tuʻufaʻatasiga e manaʻomia ai le sili atu saʻo vaʻaiga o le metabolic tali.
Gueaa Pig Afrid Microsomes
E le pei o isi rodents, Guinea pigs e leai ni vailaʻau - metaboling enzoling enzymes, pei o le cytochrome p450 2d, e mafai ona aʻafia ai le auala na latou faʻaogaina ai le auala na latou faʻagaioiga ai. E faia aiGuinea Pig Borr Microsomesfaapitoa aoga mo le suʻesuʻe ituaiga - eseʻese eseesega i vailaʻau metabolism. O la latou tulaga ese enzyme e mafai ona maua ai malamalamaaga e ono amio ai i se ituaiga ma undies metabolic prasbolis mafuaaga ma fesuiaiga o le metabolism e ono le matauina i isi metotia. O lenei mea e taua ai guinea pigs mo le faʻatusatusaina o meaola oona ma pharmacokinic suʻesuʻega.
Feline o lotoa micromeme
Feline amr microsomesua faʻaaogaina i le metabolic suesuega e iloilo pe faʻapefea ona faʻagaioia vailaʻau i pusi. O pusi e iai faʻailoga tulaga ese, e aofia ai tapulaʻa i le kupecrondization gaioiga, lea e mafai ona afaina ai metotia o ni vailaʻau. Ona o lenei,Cout Bear Microsomese taua mo le suʻesuʻeina pe faʻafefea ona faʻapea ni tagata patino i pusi, aemaise mo tagata faʻatau vailaʻau. O loʻo faʻaaogaina e faʻataʻitaʻi ai mo mea e ono oona poʻo le metabolic mataupu i fualaau faasaina ua fuafuaina mo feline faʻaaogaina ma mafai ona suʻesuʻe i totonu o le mafaufau i meaola i meaola i meaola i meaola i meaola i meaola i meaola i meaola i meaola i meaola i meaola i meaola i meaola i meaola i meaola i meaola i meaola i manu
Bovine ola micromesoso
Bovine ola microsomes, e aumaia mai povi, e taua tele i le suesueina o le metabolism o compalls faaaogaina i lafumanu. O povi e ese mai o le metabolic auala pe a faatusatusa i tagata, aemaise lava i le gaioiga o nisi Esseemes na aofia ai i le phasebolism. Boovine Lilr Microsomes o loʻo faʻaaogaina e vavalo ai pe faʻafefea ona o vailaʻau poʻo faʻatoʻaga o le a metablized i povi. E le gata i lea, o nei microsomes o loʻo faʻaaogaina e suʻesuʻe ai le ono mafai ona toe faʻatulagaina i aano o manu ma susu, fesoasoani ia mautinoa le taumafaina meaai. A o le Blagovi Microsomes faʻalauiloa faʻamatalaga o lafumanu, atonu latou te le saʻo i taimi uma i le gaioiga a tagata ona o eseesega o le aufaigaluega. Siteki i Bovine,solofanua ola micromeso,Masini a le mamoe Micrososomsma leO le Gaot Liver Microsomesua faaaogaina leaga.
O le moa a le moa
O Miltry Microsomes, A o le masani ona faʻaaogaina nai lo latou mai mammuls, e mafai ona aoga i suʻesuʻega o le Avalia vailaʻau metabolism. E masani ona aofia ai Milt Groomry Microsomesduck ola microsomes,moa ola microsomes,Turkey o le amr Microsomesma leSalu exal le Microsomes. ua faʻafaigaluegaina le iloiloga pe faʻapefea ona faʻagaioia vailaʻau i le avia ituaiga. E taua tele lea i le atinaʻeina o fualaau faasaina mo moa, faʻapea foi ma le siosiomaga suʻesuʻega e malamalama ai i le metabolism o vailaau e ono ulu atu ai i meaʻai.
Fagota ola mamago
Afa o Miss Microsomes, aemaise le nuanuaTrout ola microsomes, o loʻo faʻafaigaluegaina i le siosiomaga ma vailaʻau oona. O le iʻa e mataala i le siʻosiʻomaga o ofu tino, ma o latou olaga mataʻutia o mea taua i le suʻesuʻeina o ala o vailaʻau i Aquatic Ecoystysms. O iʻa o Microsomes e faʻaogaina foi e suʻesuʻe ai le siosiomaga o le talafatu ma alamanuia, fesoasoani e iloiloina o latou avanoa ile mimilo ma afaina ai le olaga.
Faaiuga
Microsomes na faia se mea taua i le amataga o itu tau fualaau faasaina e ala i le sauniaina o malamalamaaga taua i le metabolic tumau ma pharmacokinisikiina o sui tauva. E ala i le faʻaaogaina o le Microsomal Junway, e mafai ona suʻesuʻe e tagata e suʻesuʻeina le Ase o ITS o Metabolic Respics, Faʻasaina le ono vailaʻau, ma le suʻesuʻeina - Faʻapitoa) O le iai o Microsomes mai le tele o ituaiga, e aofia ai ma tagata ma meaola, e mafai ona sopoia - faʻatusatusaga o le vavaega o tagata ma faʻamautinoaina le saogalemu ma aoga o nofoaga fou. A o faʻaauau le atinaʻeina o fualaau faasaina le faʻaogaina, Mi Milivolomal faʻataʻitaʻiga o le a tumau i se meafaigaluega taua i le sailiga o le saogalemu ma sili atu ona lelei vailaʻau.
Keywords: metabolism mautu, phasey i metabolism, o le isi o le altabolism, prages microsoms, o le gedcolal generam skictive scility, udge. 0.1M PBS, Tris - HCL, Tagata Microsomes, CynnomolGus Monkey Com Microsomes Microsoms Microsoms Microsomes Microsomes Microsom! Gerbillinae Lima Microsomes, Balb / C Nude Lio Microsomes Microsomes Microsomes Microsomes Microsomes Microsomes Microsomes Microsomes Microsomes Microsomes Microsomes Microsom! Olaola enaena, mamoe ola microsom! O le 'oti' oti goo microsomes, Salu exal le Microsomes
Faasinomaga
O 2 Warerer faʻafaigofie O 2 felauaiga i se hepatics group boretor boretor - Faatoienisi Ata i Ula. Avanoa mai:HTTPS://www.reseschgate.net.net/figure/phase cophies cophiowway -5_Fig41
Lafoaia le tali a le PhaseBo metabolites o Ibuprofen ma isi NSIDS MA O LE TAGATA PARSMARD - Faatoienisi Ata i Ula. Avanoa mai: https://www.reseschgate.net.net/Fagure/Tobis -
Taimi o le taimi: 2025 - 04 - 03 11:50:30