Adc Performance Yakaratidzirwa neCathepsin B in DS8201A uye GGFG - DXD Systems

Nhanganyaya

Antibody - Zvishongo zvezvinodhaka Nekusimudzira bundu - Targeting Antibody, inochinjika kana isingachinjiki

Michina yemitambo ye adcs uye basa reCathepsin b

ADCS yakagadzirirwa kusarudza kuendesa vamiririri veCyTototo Kamwe kusungwa, iyo Adc iri mukati memucherechedzo - yakadururwa endocytosis uye inotengeswa kune iyo lysocy, uko mushonga wekutsikisa unosunungurwa. Imwe yekiyi enzymes inosanganiswa mune ino kubudiswa ndeye cathepsin b, chinoshoreka checysteine ​​proteise. Cathepsin B inotora basa rakakosha mukuchenesa Peptide - Yakavakirwa Linckers muAdcs, inoverengera inobata zvinodhaka zvinodhaka mukati meTumor masero paunenge uchidzora hurongwa hwehukama.

DS8201A: Inotevera - Chizvarwa ADC

DS8201A, inozivikanwawo se [FAM - Trastuzumab Deruxtecan - Inonongedzera ADC iyo yakaratidza inoshamisa yekubata Inosanganisira trastuzumab - inotorwa antibody yakabatanidzwa kune iyo ine simba topoisomerese ini inhibitor payload kuburikidza neyechinguvana linker. Iyi adc ine yakanyanya kukosha drug - kuti - Antibody ratio (Dar) achienzaniswa neyakagara her2 - Inonongedzera ADCS, inotungamira kuisirwa bundu uye yakagadziridzwa anti - cancer chiitiko. DS8201A inozivikanwa zvakare kuti yaisanzwisisika, ichibvumira kubhadhara iyo kudzikisira uye kuuraya cancer cancer cancer zvisinei neyekutaura kwake.

Ggfg - DXD: Iyo Inosimudzira Linker in DS8201A

Chinhu chakakosha muDS8201A's Budiriro yaDS8201A ndiyo yakasarudzika yakasarudzika linker, GGFG - DXD. Iyi Peptide - Yakavakirwa Linker ine Glycine - GLYCINE - GGFG Iyo GGFG Lethker yakagadzirirwa kuvandudza kugadzikana mukuenderera mberi uchiona kukurumidza uye kudzorwa kusunungurwa kwemushonga wekutsikisa mumutauro wejira.

Mhedziso

ADCS yakadai seDS8201A zvinomiririra paradigm kuchinja mu cancer kurapa, kupa zvakanangwa kuburitswa kwesimba rine simba epothorapetic vamiriri vane mutoro wehurongwa. Basa reCathepsin B mumubatanidzwa, Iyo Yemukati GGFG - DXD Linker System, uye Yakanyanya Kubudirira kweDS8201A pamwe chete Simbisa kufambira mberi muADC Tekinoroji yeADC. Sezvo ADC kukura kunoenderera mberi kushanduka, kuwedzera kuratidzwa kwehuwandu hwevanhu, kubhadhara, uye kunongedza antibodies kunokura nzira yekurapa kwegomarara uye kwakarongeka.

Keywords: Adc Linker, Payload Kuburitswa, Chombo Lossome, Lysosomal Kugadzikana, Lysosome Catabolism, Cathepsin B, DS8201A, GGFG - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD - DXD