1. Nhanganyaya: Kunzwisisa Chiverengero chevanhu vemufananidzo
Mukukura kwemazuva ano zvinodhaka, kufanotaura kuti mushonga unoita sei mumuviri wemunhu zvakakosha kuti uve nechokwadi chekugona uye kuchengeteka.Chiropa chevanhu chovorosomes. Zvidzidzo izvi zvinobatsira vaongorori vemishonga vanonzwisisa mashandiro anoita zvinoitwa nemishonga nguva isati yasvika miedzo yekiriniki, kuderedza nguva yekuvandudza uye mutengo.Chinyorwa ichi chinoongorora chikamu chemugove wemufananidzo wemugodhi mune zvinodhaka zvemishonga, mafungiro avanoita mapaketi, uye kukosha kwavo mukugadzirisa zvinodhaka zvekushanda kwakavandudzwa uye kuchengeteka.
2. Ndechipi chinonzi chiropa chevanhu chovaridzi?
Chiropa chevanhu chirovina microsomes ndeyekupedzisira zvidimbu zvinobva kune munhu chiropa chemuchiropa. Ivo vane kiyi enzymes inobatanidzwa mune zvinodhaka metabolism, kunyanya:Cytochrome P450 enzymes (Cyp450s)- Inotarisirwa chikamu chandineterera, kusanganisira oxidation, hydroxilation, uye delkylation.
UDP - Gluculonosyltransferases (Ugts)- Inobatanidzwa muChikamu II Conjugation maitiro, senge gluculoronidation, inosimudzira zvinodhaka zvinodhaka zvekunyaradza.
Hlms anoshanda seVitro system yekuenzanisa chiropa metabolism, kuvaita kuti vazvikudzike pakuwanikwa kwezvinodhaka uye kukura. Iyi microsomes inobvumira vaongorori kuti vadzidze nzira yeMeturedzero, tarisa zvinodhaka clearance matanho, uye kufanotaura zvinogona kuve zvine chepfu mhedzisiro pamberi pemiedzo yevanhu inotanga kuitika.
3. Kuita kuti chiropa chevanhu chivakwa chinokanganisa sei pharmacokinetics
Pharmacokinetics (PK) zvinoreva kufamba kweinodhaka kuburikidza nemuviri, kusanganisira kuparadzaniswa kwayo, kugoverwa, metabolism, uye kushamisika (admeton). Pakati peizvi, metabolism chinhu chakakosha chinokanganisa kushanda kwezvinodhaka uye kuchengeteka, uye hlms vanoita basa rakakosha mukunzwisisa maitiro aya.Metabolic kugadzikana- inosarudza iyo hafu - hupenyu uye cleararance rate yemushonga, kupesvedzera madhiri ekurudziro.
Kuumbwa kweMetabolites- inozivisa inoshanda kana ine muchetura metabolites izvo zvinogona kukanganisa zvinodhaka kugona kana kuchengeteka.
Mushonga - Kubata kwezvinodhaka (DDIS) - anoongorora kana paine zvinodhaka kana madhiragi metabolic enzymes, anogona kuchinja zvakanyanya kana kutakura kweCO - ZVINOGONESWA ZVINOGONESWA.
Nekuongorora izvi zvinhu, vatsvagiri vanogona kufanotaura kana mushonga ucharamba uchishanda zvakakwana kuti ubudirire kana kuti zvichakurumidza kuita metabolized uye zvinoda kugara uchiramba.
4. Zvikumbiro zvechiropa chevanhu chemufananidzo mukuvandudza zvinodhaka
4.1 Kufanotaura zvinodhaka metabolism uye clearance
HLMS inobatsira kuona kuti nekukurumidza zvinodhaka zvinorwadza sei muchiropa, izvo zvinokanganisa zvakananga dosage yaro uye yekufambisa frequents. Zvinodhaka zvine huwandu hwakareba clearance dzinoda zvakanyanya kana kazhinji kazhinji madhiri, nepo avo vane zvishoma zvishoma metabolism vanogona kuunganidza, vanogona kukonzera kuchiva.4.2 Kuongorora Zvinodhaka - Kubata kwezvinodhaka (DDIS)
Mamwe madhiragi anogona kundinyadzisa Hlm - Yakavakirwa muzvidzidzo zvinobatsira makambani emishonga anozivisa idzi njodzi pamberi pemiedzo yekiriniki, ichirondedzera kuchengeteka kwemurwere.4.3 Kuziva ane chepfu metabolites
Mamwe madhiragi anogadzira inoshanda metabolites inogona kutungamira kune chiropa kana zvimwe zvinokanganisa mhedzisiro. Kuongorora pamwe neHLM kunobatsira kuona aya metabolites kutanga, kuderedza njodzi inosanganiswa nemishonga - yakakundwa chiropa (dili).5. Zvakanakira uye zvisingakwanisi kushandisa chiropa chevanhu
5.1 Zvinodikanwa
Mutengo - Inoshanda - Zvimwe Zvehupfumi pane KUPEDZISIRA HERE - Saizi dzeKiriniki Miedzo.Mhedzisiro inobereka - inopa zvisingadzivisiki zvinodzorwa pasi pemamiriro ekudzora eLab.
Yakakwira - Kuburitsa kuongorora - inogonesa kuongororwa kwekukurumidza kwevakadzikama zvinodhaka.
5.2 zvisingakwanisi
Anoshaya ruvara rwakazara rwechiropa - haritevedzere kune vatakuri vanobatanidzwa mune chikamu iii metabolism.Haikwanise kutevedzera mimvuri eropa anoratidza mikana - haina kudzokorora chaiyo - nguva chiropa ropa kuyerera masimba masimba masimba.
Marudzi akasiyana-siyana - data kubva kumhuka microsomes inogona kunge isingafanane zvakakwana zvinodhaka metabolism.
6. Iphae Biosciences: Kufambira mberi kwezvinodhaka metabolism ongororo
Yakagadziriswa kuNorth Wales, Pennsylvania,FiosciencesIro rakakwira uye rinotumidzwa neTech Enterprise kutsvagurudza, kusimudzira, uye kugadzirwa kwezvinhu zvakasarudzika, kusanganisira kukwirira - mhando yemunhu chiropa chemuchoruviro. Nekuzvipira kwakasimba kwehunyanzvi hwesainzi, timu yedu yehunyanzvi inopa zvishandiso zvakakosha kune vanotsvaga pasi rese, kuganhurira kufambira mberi mukufamba kwemishonga uye pharmacokinetics (DMPK) zvidzidzo.7. Mhedziso: Basa reChiropa Yevanhu Midzimusi Mukubudirira kwezvinodhaka
Hlms anotamba chinzvimbo chakakosha mukunzwisisa metabolism, anoverengera kuchengetedzeka, uye anogadzirisa zvinodhaka. Nekubatanidza HLM - Kuzvidzora Kwekuvandudza Mufambiro, makambani emishonga anogona kukurudzira zvinowanikwa zvinodhaka, kuvandudza kugona kwezvinodhaka, uye kusimudzira kuchengeteka kwemurwere.PaPfeka-fiosciensces, isu takazvipira kutsigira vanoongorora nevezvivakwa vezvinyorwa zvekuzvarwa, vachibatsira kutyaira zvesainzi vanowanikwa mune ramangwana remushonga wekurapa.
Nguva Yakatumira: 2025 - 02 - 17 16:22:44