Kumashure
Nekuda kwehunhu hwayo hwakasarudzika hwehunyanzvi, Sirna zvinodhaka zvave kutarisisa kwekutarisa mumunda wekutsvagurudza kwezvinodhaka uye kukura kwemakore apfuura, uye ndeimwe yeanokurumidza kukura genera marapirwo. Achienzaniswa neyechinyakare mishonga mishonga yemadhiragi uye mushonga unodhaka, zvichikwanisika kubuditsa zvinodhaka, zvinowedzera, kuwedzera kune madhiragi madiki madhiragi "kunze kweyechitatu wave mishonga. Wechitatu mafungu emishonga yekuwedzera kune mishonga madiki madhiragi uye antibody zvinodhaka.
Nekudaro, sekirasi idzva yemanyorerwe emadhiragi, zvinodhaka zvinodhaka, zvinodairwa nemishonga yemishonga yemishonga yemidhara uye inodhaka mishonga yemakemikisi, iyo inoisa dambudziko idzva rekusimudzira madhiragi ekutanga kweSirna zvinodhaka zveSirna.
Nhanganyaya yeSirna Zvinodhaka
Sirna mishonga, zvakare inozivikanwa seOligonucleides (Oons), tarisa kune zvinodhaka - Yakagadzirira Oligonucleides kazhinji 18 - 30 nt pakureba. Diki Rna Zvinodhaka Zvinosanganisira Diki Rna
Kutsvaga kwazvino kunotarisa pane matatu madhiragi eSirna zvinodhaka: Asi, Sirna naAptamer. Akasiyana oligonucleides ane masangano akasiyana echiito, uye vanotamba chinzvimbo chevanotenda pamatanho akasiyana ePathogeneis. Aso naSirna vanoita pachiyero chevanotarisirwa MrNN; Aptamer zvakananga inthebits chiitiko chemurata anobatanidzwa muPathogeneis. Pfungwa yavo yakajairika ndeyekuti ivo vanopindira vachiratidza majini anotariswa kuti vazadzise chinangwa chekurapwa kwechirwere.
Zvakazara, iyo yakasarudzika michina yekuita mishonga madiki acid mishonga ine zvinodhaka zvenguva pfupi, zvisingaite zvekutakura zvinodhaka, kureba Zvinoonekwa sechizvarwa chechitatu chehunyanzvi hwechikwereti hunosimudzira shanduko yeindasitiri yemishonga ichitevera zvinodhaka madiki uye antibody zvinodhaka. Makambani mazhinji uye mishonga mishonga yemishonga yakaiswa mukutsvaga kwekutsvagisa uye kuvandudza kweSirna zvinodhaka.
Mamiriro ezvishoma nucle acid zvinodhaka pamusika
Yakatenderwa zvidiki zvidiki acic acid zvinodhaka:
- Antisense Oligonucleides (ASOS): Aya rimwe chete - Strads DNA Assable asos inosanganisira:
- Nusinersen (Spinraza): Inotenderwa kuti Spinal Music Atrophy.
- ETEPLIRSEN (Exongys 51): Target
- Inoteren (tegsdi): inobata nhaka yetsitsi
- Diki Rinorerutsa Rnas (Sirnas): Double - Yakamanikidzwa Rna Molecules inosimudzira kusvibiswa kwematare MrNA.
Yakatenderwa Sirna Kurapa inosanganisira:
- Patisiran (Onpattro): Yekutanga FDA - Yakabvumidzwa Sirna mushonga, kugadzirisa nhaka yedhisheni.
- Givosiran (Givlaari): yeAppatic Hepphatic Porfiriya.
- Lumasiran (OxLumo): Target Spent Hyperoxaluria Type 1.
- APTAMERS: Pfupi, yakarongedzwa nucleic acids inosunga kune chaiyo mapuroteni.
- Pegptnanib (Macuggen): Anptamer akatenderwa zera - inoenderana nemacular kuderera.
Mazwi akakosha: Galana, Sirna Dhivhiri, chirungu
Kutumira Nguva: 2025 - 04 - 09 10:04:06