Nhanganyaya
T masero mimwe chinhu chakakosha cheiyo immune system, ichiridza basa rakaoma mukuzivisa uye kurwisa hutachiona. Maitiro eT cell activation is a clomed Kunzwisisa maitiro aya kwakakosha pakufambira mberi kumucheto nemichero uye kukudziridza kurapwa kwakabudirira kune zvirwere sekenza uye autoimmune diskmune. Munyaya ino, isu tichazoongorora matanho akasiyana eT cell activation, kubva pakuratidzira kwekuwedzera kuwanda uye kudzora, ndichiratidzawo kufambira mberi kwekutanga mukatit cell activation kits.
Antigen Mharidzo uye Kuzivikanwa
● Basa reAntigen - Kupa Masero (APCS)
Antigen - Kuburitsa masero (APCS) akakosha mukutanga kweT cell activation. Aya masero ane hunyanzvi, ayo anosanganisira masero emadumbu, macrophages, uye mabwe, anobata hutachiona kubva kune vafambi uye ovabuditsa pamusoro pe t masero. Iyi mharidzo inoitika kuburikidza neakakura hutsinye kugutsikana
● Mahombekombe ehupfumi akaomarara (MHC) kudyidzana
Kubatana pakati peMHC mamorekuru kuAPCS uye T cell Receptors (TCRS) paT masero idombo reT cell activation. MHC kirasi i molecules iripo endoenayo abatwa neCD8 + cytotoxic t masero, nepo MHC kirasi II oxowele Atigens kuenda kuCD4 + Bible T Masero. Uku kudyidzana kukuru kunoona kuti ma s cell anogona kunyatsozivisa uye kupindura kune huwandu hwakawanda hwehutachiona.
T Cell Receptor (TCR) Engagement
● Ruzivo uye basa reTCR
Iyo T cell Receptor (TCR) ndeye yakaomeswa protein chimiro chiri pamusoro pe t masero. Yakatemerwa naAlfa naBeta Chain, iyo TCR inoziva uye inosungira kune chaiyo maantigent yakaunzwa naMHC mamorekuru. Iko kusiyanisa muTCR chimiro kunobvumira kuzivikanwa kweiyo madhiri akasiyana ekudzivirira, kugadzira t masero anochinjika zvakanyanya.
● Rondedzero yekunzwisiswa kwekunakidza
Kujeka kweTCRS kunotemerwa negadziriro yakasarudzika yeAmino Acids mukati mematunhu anoshanduka eAlfa naBeta maketani. Uku kuzivikanwa kwakakosha mukubudirira kwekunyatsoita kwemhinduro yekudzivirira Yakakwira - Hunhu TE T Cell activation kits dzakagadzirirwa kuchengetedza iyi chaiyo mukati mekuedza maitiro, ichipa yakavimbika uye inobereka mhedzisiro.
CO - STIMULUTOR Signals
● Kukosha kwezviratidzo zvechipiri
T cell activation haisi yega inotsamira pakuzivikanwa kwekunakisa; Zvinodawo sekondari, CO - Signularor Signals kuenderera. Izvi zvikwangwani zvinodikanwa kuti ushandise zvizere masero uye kudzivirira anergic (nyika isingashande. Iko kusavapo kweCO - Simpulory Signals inogona kutungamira mukushivirira kusimba, izvo zvakakosha kuti kudzivirira autoimmune nezvirwere.
● Mamorekuru akakosha akabatanidzwa
CO - STIMULARILY MOLECULESS yakadai seCD28 paT masero uye B7 paAPCS Tamba chinzvimbo chePivotal mukupa masaiti anodiwa eT cell activation. Kubatanidzwa pakati peCD28 uye B7 inosimudzira t cell proliferation, kupona, uye cytokine kugadzirwa. Mamwe CO - Anosimudzira mamorekuru, kusanganisira ICOS uye ox40, inowedzera kunongedza activation uye kusiyanisa kweT masero. T cell activation kits yakagadzirwa nevatengesi vevatengesi vanobatanidza mamorekuru aya kuti vatore simba uye vanobudirira t cell activation mune labhoratori marongero.
Signal Shanduko nzira
● Intracellar Signing Signisms
Kamwe chete iyo TCR uye CO - Inosimudzira mamorekuru vemo vaita nhare dzadzo, cascade ye intracellar kusaina zviitiko zvinotangwa. Iyi nzira yekusaina inomiririra inosanganisira nhevedzano yezviitiko zvefoni uye activation yekiniyasi dzakasiyana-siyana, senge lck uye zap - 70. Izvi zvinyadzo phosphorylate sownstream adapter puroteni, zvichitungamira kuChinyorwa chemahara akawanda kusaina nzira, kusanganisira iyo MapK, NF - κB, uye NFat nzira.
● Kwakanaka mapuroteni uye ma enzymes akabatanidzwa
Mapuroteni akadai saLat (Linker ekutora kweT masero tema) uye SlP - 76 (Sh2 Domain ye76 KDAFOLDS, Kuronga uye Kuwedzera Signals inodiwa kuti tite cell activation. Enzymes saPhosholipase C - γ (plc - Yakakwira - Huzi TE T Cle Cell Activation Kits inowanzo shandura aya makuru mapuroteni uye enzymes kuve nechokwadi chekushandura chiratidzo chekushandurwa mune yekuedza marongero.
Cytokine kugadzirwa uye kupindura
● Mhando dzeCytokines dzakagadzirwa
Activated t masero anoburitsa makirikina akasiyana-siyana anonyadzisa mhinduro yemuviri. Aya maCytokines anosanganisira Interleukins (IL - 2, IL - 4, IL - 6), Interfons (iFN - Imwe neimwe cytokine ine zvakananga mabasa, sekusimudzira t cell kuwedzera, kuisanganisira basa rekuchinjisa, uye kudzora kuzvimba.
● Basa mu t cell mutsauko uye kuwedzera
Cytokines anotamba chinzvimbo chechikumbiro chekusarudza iyo fate yeiyo activated t masero. Semuenzaniso, IL - 2 inotsoropodza yekuwedzera kwekuwedzera kwe t masero, nepo il - 12 inosimudzira kusiyanisa kweNAïve t masero mu th1 thing. Kuvapo kweiyo cytokura Kiredini kunoita kuti titer tit vazove mubatsiri t sero, cyttopot t cell, kana yekugadzirisa ter cell. T cell activation kits kubva kune vanozivikanwa vanogadzira kuti vagadzikane kunyatso kuyera kugadzirwa kweCytokine kugadzirwa, kufambisa zvakadzama zvidzidzo zveT cell basa uye kusiyanisa.
T cell mutsauko
● Kuumbwa kweakasiyana t Services subsets
Kutevera activation, t masero kusiyanisa musi dzakasiyana, imwe neimwe ine mabasa akasiyana. CD4 + Mubatsiri T masero anogona kuwedzera kusiyanisa thy1, th2, th1, uye loglatory t masero (Tregs), imwe neimwe inokodzera kutamba dzakasiyana siyana mumisangano yakasarudzika. Masero thd
● Kuita mabasa ega ega ega subset
Iyo inoshanda hunyanzvi hwe t cell subsets inovimbisa kudzikisira kudzvanywa kwemuviri kune akasiyana hutachiona. Masero Th1 anogadzira ifn - γ uye akakosha pakurwisa hutachiona hwehutachiona hwakaita mavairasi uye mamwe mabhakitiriya. Th2 masero anogadzira IL - 4, il - 5, uye IL - 13, izvo zvakakosha pakurwa nehombodo yekuwedzera. Th7 masero secrete il - 17 uye anobatanidzwa mukuzvimba zvisingaperi uye zvirwere zvekutadza. Regulatory T Masero anogadzira IL - 10 ne tgf - β, kuchengetedza immune hemiostasis uye kudzivirira autoimmunity. Inventive t cell activation kits inofambisa iyo muVitro kusiyanisa uye Inoshanda kuongororwa kweaya mairi ekusimbisa, kubatsira kutsvagisa mukusimudzira uye kuratidzira kukura.
Kuwedzeredza kwekuwedzera uye kurangarira kugadzirwa
● Kuwedzeredza kweiyo activated t masero
Pakugamuchira masaini ekutonga uye cytokine kukurudzira, activated t masero anokurumidza kuwedzera kuwanda. Kuita uku, inozivikanwa seyako yekuwedzera, inoguma nehuwandu hukuru hwemhedzisiro t masero anogona kuita zvinobudirira kune antigen. Kuwedzeredza kunofambiswa neCytokines se IL - 2, iyo masaini kuburikidza neIL - 2 Receptor kusimudzira kufambira mberi kweCercalion uye kupona.
● Kugadziriswa kweMemory T Masero
Chimiro cheiyo yekushongedza Immune System ndiko kuumbwa kwekuyedzwa kweT masero, inopa kureba - kusadzivirirwa. Mushure mekubvumidzwa kwePathogen, mamwe masendimita tes akasiyanisa mu masero t masero. Aya masero anoramba ari mumuviri uye anogona kukwira nekukurumidza uye akasimba mhinduro pane re - kuratidzwa kune antigen imwechete. Yakakwira - Huzi TE T Cell Activation Kits iningi mukudzidza muchimiro pasi pekurangarira ndangariro t cell kuumbwa uye kugadzirisa.
Kudzora kweT cell activation
● mechanisms eyekuchengetera mauminefintespoint mutemo
T cell activation yakasimba nekudzivirirwa nemhedzisiro yekudzivirira kudzivirira maitiro akawandisa ekudzivirira uye autoimmunity. Immune yekutarisa inhibitory nzira dzinoshanda semabhureki pamushonga unoshanda. Key Immune CheckPoints inosanganisira CTLA - 4 (Cytotoxcy T - Lymphocyte - Crotein 4) nePD -
● Basa reInhibitory Signals (CTLA - 4, PD - 1, nezvimwewo)
CTLA - PD - 1, pane kusungira kune yayo ligands PD - L1 uye PD - L2, inhibits t cell Receptor uye inoderedza cytokine kugadzirwa. Izvi zvikwangwani zvisingaiti zvakakosha kuti urambe uine simba rekushivirira uye kudzivirira autoimmunity. T cell activation kits yakapihwa naIfaseBiosciences inosanganisira zvikamu zvekudzidza nzira idzi dzekuzvidzivirira, kupa ruzivo rwekushandiswa mukunyorwa kwemuviri uye zvinogona kuronga zvinangwa.
Clinical zvinonzwisisika uye zvirongwa zvekushandisa
● Zvakarereka zve autoimmunity uye cancer
Aberations muT cell activation inogona kutungamira kune autoimmune chirwere, uko pachako - tsanangudzo t masero anorwisa hutano hwakanaka. Zvakare, isina kukwana t cell activation inogona kukonzera kusawirirana kusungwa, kubvumira hutachiona uye kenza yekuwedzera. Kunzwisisa vanonetsa veT cell activation vane zvakaringana zvinangwa, vachipa nzira dzekuvandudza marapirwo ekurapa maitiro ekudzivirira.
● Zvirongwa zvekuratidzira zvinonakidza t cell activation
Zvirongwa zvezviratidziro zvinovanzika Car - T Cell kurapa kunosanganisira mainjiniya t masero ekuratidzira chimeric antigen anotora cancer cancer masero cancer. Aya marapirwo airatidza kubudirira kunoshamisa mukurapa mamwe ma cancer. Pamusoro pezvo, mazano ekutaurisa kushivirira kusavimbika kuri kuongororwa chirwere autoimmune. Yakakwira - Huzi TE T Cell Activation Kits kubva kune vanotungamira vagadziri zvinhu zvakakosha mukukura uye kuongororwa kweaya manhamba ekurapa.
Nezvesimba rephae bioscience
Musoro wakagadziriswa muNorth Wales, Pennsylvania, Phosciences ane hunyanzvi, uye mutsva weChinyorwa Kuzvidza ruzivo rwakakura uye nekuda kwesainzi yekutsvaga kwesainzi, timu yedu yesainzi yevanoona hunyanzvi hwekuita zvinhu zvakasarudzika uye kubatsira vaongorori muhupenyu hwavo hwesainzi kunobatsira kuzadzisa zvinangwa zvavo zvekutsvagisa. Kutsvaga r & d yakanaka ye "Ruzivo Runosimudzira, Runyanzvi Remangwana", Iphase yakatanga akawanda R & D, Carehouses, uye muEurope, uye Europe nyika dzinopfuura gumi nembiri.
Kutumira nguva: 2024 - 09 - 25 11:40:30