Ka hortag ah - daroogada ay ku kacdo fikradaha iyo farsamooyinka

Hordhac Daawooyinka ADC

Daawada ka hortagga (ADCC) (ADCC) (ADCC) waxay matalaan fasalka aasaasiga ah ee daweynta kansarka ee la beegsanayo oo loogu talagalay in lagu wanaajiyo cayiman iyo wax ku oolka ah ee kemotherabi. Iyaga oo isku daraya unugyada ka hortagga monoclonal ee leh wakiilada cytotoxic-ka ee xoogan, ADCs ayaa si toos ah daroogada ugu gudbiya unugyada kansarka, yareynta waxyeelada unugyada caafimaadka qaba. Fikradda koowaad ee 1980-yadii, ADCS waxay u soo baxday daaweyn caafimaad oo ansax ah, oo ka badan Dozen FDA - wakiilo la ansixiyay, oo ay kujiraan ADTetris® (Brentuximab Vedotin) iyo Kadcyzumab Emthine).

Qaybaha aasaasiga ah ee ADCS

ADCS waxay ka kooban tahay seddex qaybood oo muhiim ah:

• - Antibody:Antibody-ka Monoclonal (Mab) oo ku xidhnaa buro: Antigen gaar ah (E.G., HER2 ee kansarka naasaha ama CD30 ee limboon). Ka hortaga ka hortaga ayaa hubiya in lagu bartilmaameedsado unugyada kansarka.
• - LinkedER:Buundo kiimiko ah oo isku xiraya ka hortar-ka-saarista mushaharka. Xasiloonideeda ayaa go'aamisa haddii daroogada lagu sii daayo dhiiga ama gudaha unugyada kansarka.
• - Lacag-bixiye:Dawada cytotoxic (E.G., authistatins, Maytsinoids) ayaa mas'uul ka ah dila unugyada kansarka.

- ADC Linked Chentary

Xarkaha ayaa muhiim ah oo isku dheelitiraya xasilloonida ADC iyo waxtarka. Waxay ku dhacaan laba qaybood:

1. Xiriiriyaha la xoreeyay

Kuwani waxay sii daayaan mushaharka mushaharka iyadoo la raacayo xaalado gaar ah oo gudaha ah:

• - ph - xiriiriye xasaasi ah:Degdeg ku jirta deegaannada aashitada (tusaale ahaan, endostomes / reysomes). Tusaale: Isku xirka hydstrazone ee loo isticmaalo mylotarcg® (gemtuzumab ozogamicin).
• - Enzyme - xiriiriyeyaasha xasaasiga ah:Ku daadisay ilaalin (tusaale ahaan, cathepsin b) ama fosfoorasyada. Tusaale: valline - Xiriirka citrulinene ee Adcittris®.
• - Glutathoone - Xiriiriyayaal xasaasi ah:Ku tiirsanaanta heerarka Glutatullar Glutathellar-ka si loo jebiyo dammaanadaha is-dhigista.

2. - Khubaro aan la cuni karin

Kuwani waxay u baahan yihiin nabaad-guurka lifaaqa ee Landossomes-ka si loo sii daayo lacagta mushaharka (E.g., xidhiidhka la-taliya ee Kadcyla®). Aan - xiriiriyeyaasha aan la dulqaadan karin waxay bixiyaan deganaansho badan oo plasma ah laakiin waxay xad u yeelataa saameynta b loola socdo.

Qaababka Siidaynta Lacagta

Qaababka sii-deynta daroogada waxay kuxirantahay nooca Lince-ka:

1. Xiriiriyaha la xoreeyay:

• - Jawiga aashitada:PH - Xiriiriyaasha xasaasiga ah hydrobyze ee endosomes (pH ~ 5-6).
• - Cheavage enzymatic:Ka-faa'iideysiga Lysosomes-ka ayaa jabisay Peptide - xiriiriyeyaasha ku saleysan.
• - Dhimis:Heerarka dheellitirka sare ee unugyada kansarka waxay yareeyaan isku-dhafka isku-dhafan.
• - Saamaynta Taajeejinta:Xannaaladaha mushaharka la sii daayay waxay ku kala duwanaan karaan unugyada deriska ah, faa'iido u leh butrogenenous Bumpomes laakiin waxay halis ugu jiraan unugyada caafimaadka ee u dhow.

2. Non - xiriiriyeyaal la daaxi karo:

• Ka hortaga ka hortaga Lysomes, wuxuu sii daayay mushaharka (E.G., Lysine - MCC - DM1 ee Kadcyla®).Wax saameyn ah ma leh, oo yareynaysa -

Caqabadaha iyo tilmaamaha mustaqbalka

• - Xulashada bartilmaameedka:Antigens waa in lagu muujiyaa burooyinka si looga fogaado - bartilmaameedka / damida - sunta burada.
• - Kordhinta Linger:Isu dheellitirka xasilloonida iyo daroogada wax ku oolka ah ee daroogada ayaa weli ah mid muhiim ah.
• - Tusmada Daaweynta:Hagaajinta daroogada - Qiimeynta ka hortagga (Daar) iyo farsamooyinka ciribtirka (E.G., goobta - isku-darka gaarka ah) si kor loogu qaado waxtarka.
• Abuuritaan:Isku-darka ka hortagga ah ee aadka, proprug - xiriiriyeyaasha ku saleysan, iyo daweynta isku-darka ee xakameynta isbaarooyinka ayaa ka hortaga isbaarooyinka lagu sahamiyo.

Gabagabo

ADCCS waxay u muujineysaa isku-dhafka dawada saxda ah iyo occology, oo bixiya xalka loogu talagalay kansarka la dagaallanka kansarka. Sida Techne Thinker-ka Linker-ka iyo Bixinta Waqtiga Kala-duwanaanta, ee ku xigta - Jiil Jiil ah ayaa u ballan qaadaya waxtarka weyn ee waxyeellooyinka la dhimay, oo ka ah kaalintooda taranka kansarka casriga ah.

Furayaasha