HordhacHepatocytes aasaasiga ah
Heepocytes-ka aasaasiga ah ee hepatocytes-ka waa aasaaska beerka ee cilmi baarista beerka waxayna muhiim u yihiin fahamka shaqada beerka, dheef-shiid kiimikaadka daroogada, iyo cudurada beerka. Sida nooca koowaad ee unugyada koowaad ee laga helo beerka, hepatocytes wuxuu ka kooban yahay ku dhawaad 70 - 80% ee cufnaanta cytoplasmic-ka beerka. Waxay ku ciyaaraan doorar muhiim ah howsha dheef-shiid kiimikaadka, hurgunka, iyo isku-darka borotiinka. Qodobkaani wuxuu ku dhexjiraa adduunka xasaasiyadda ah ee hepatocytes-ka koowaad, sahaminta muhiimada, codsiyada, iyo tilmaamaha mustaqbalka.Go'doominta iyo dhaqanka hepatocytes
● Farsamooyinka loogu talagalay go'doominta hepatocyte
Heepocytes-ka aasaasiga ah ayaa laga go'doomiyaa unugyada beerka iyada oo loo marayo hanaan nafaqo leh oo hubiya sareyso Hawshani sida caadiga ah waxay ku lug leedahay beerka ee ku saabsan colagosenase si ay ugu kala fogeeyaan unugyada matrix beerka, oo ay ku xigto taxane ah oo ah finanka iyo tillaabooyinka laaweyaasha si loo daahiriyo hepatocytes. Tayada hepatocytes-ka la helay waa muhiim, maadaama ay go'aamiso adeegsigooda cilmi baarista iyo codsiyada caafimaad.● Caqabadaha dhaqanka Hepatocyte
Ku Beeshada Heepocytes-ka koowaad ee hepatocytes-ka ayaa leh caqabado aad u wanaagsan, ugu horeyn sabab u ah noloshooda xaddidan iyo saboolnimada in lagu lumiyo beerka - howlo gaar ah waqti ka dib. Joogtaynta sare Horumarinta farsamooyinka dhaqanka, oo ay ku jiraan CO - Nidaamyada dhaqanka iyo saddex -Doorka hepatocytes ee beerka
Hawlaha dheef-shiid kiimikaadka ah ee hepatocytes
Heepocytes-ka aasaasiga ah waa is-miidaaminta dheef-shiid kiimikaad ee beerka, oo mas'uul ka ah Myriad ee habraaca muhiimka ah, oo ay ku jiraan Gluconegogenesis, keydinta Glconeen, iyo dheef-shiid kiimikaad. Waxay door muhiim ah ka ciyaaraan joogtaynta gulukoos iyo lipid-ka-hortagga, iyaga oo ka dhigaya meel muhiim ah oo ku saabsan daraasadayaasha dheef-shiid kiimikaadka sida sonkorow iyo buurnaanta.Geedi socodka wax-ka-qabashada
Hepatocytes-ka waxay udub dhexaad u yihiin ka-saarista walxaha lagu joojiyo iyo walxaha soo noqnoqda, oo ay ku jiraan daroogada iyo sunta. Iyada oo loo marayo wejiga dheef-celinta dheecaanka ee II iyo wejiga dheef-celinta ee II, oo ay fududeysay sumcad enzymes sida cytochroso p450s, hepatocytes wax ka beddelo oo ku milmaysa xeryadan biyo badan - Fahmitaanka habraacadan ayaa muhiim u ah horumarka daroogada waxayna qiimeyneysaa hapatotoxicity ee xeryahooda cusub.Codsiyada daahfurka daroogada iyo tijaabada
● hepatocytes ee dawooyinka farmashiyaha
Daawooyinka daroogada, asaasiga ah ee hepatocytes-ka aasaasiga ah ayaa muhiim u ah barashada daawooyinka dawooyinka dawooyinka, laanta dawooyinka farmashiyaha ee ay quseyso dhaqdhaqaaqa daroogada ee jirka dhexdiisa ah. Waxaa loo isticmaalaa in lagu qiimeeyo nuugista, qaybinta, dheef-shiid kiimikaadka, iyo astaamaha wasakhda ah ee musharixiinta dawooyinka cusub. Iyada oo ah qayb ka mid ah soo-saare koowaad ee Heepatocytes-ka aasaasiga ah ee hepatocytes, shirkadaha ayaa ku dadaalaya inay bixiyaan hepatocytes-ka oo u fududeynaya qiimeynta saxda ah ee loo yaqaan 'Reme'.● Daraasadaha toxicology-ka ee la adeegsanayo hepatocytes
Heepocytes-ka aasaasiga ah wuxuu door muhiim ah ka ciyaaraa daraasadaha sunta ah, taasoo u suurta gelisa cilmi baarayaal si ay u qiimeeyaan hapatotoxichicity daroogada iyo kiimikooyinka cusub. Jiritaanka sareHepatocytes ee dawada dib-u-cusboonaysiinta
● Isticmaal daawooyinka dib-u-cusboonaysiinta beerka
Awoodda hepatocytes-ka aasaasiga ah ee dawada dib-u-eegida waa mid aad u weyn, gaar ahaan macnaha guud ee ku-tallaalidda beerka iyo dib-u-cusboonaysiinta unugyada beerka. Cilmi baaris ayaa diiradda lagu saarayaa iyadoo la adeegsanayo hepatocytes si ay u horumariyaan aaladda beerka la dhaqanka iyo daweynta unugyada ee beddeli kara ama ku taageeri kara shaqada beerka ee bukaannada qaba cudurka beerka oo ku dhaca beerka qaba.● Guul darrooyinka injineerka unugyada
Injineeriyada unugyada beerka ayaa looga golleeyahay in lagu abuuro unugyada beerka ee aasaasiga ah ee hepatocytes-ka aasaasiga ah. Horumarka arimahan, sida horumarinta muuqaalka biocolds iyo sedex - cabir yareynta cabbirka abuurista dhismayaasha unugyada ee beerka oo bixiya siyaabo kale oo lagu beddelo beerka.Qaababka molikaular ee ku jira hepatocytes
● Saxeex wadooyinka wareejinta
Heepocytes-ka aasaasiga ah ayaa ku lug leh wadiiqooyinka wareejinta ee calaamadaha xasaasiga ah ee xajiya shaqada beerka, oo ay ku jiraan gulukooska dheef-shiid kiimikaadka iyo sankaaga bile acid. Fahmitaanka wadooyinkaas waxay soo bandhigaan aragtiyo ku saabsan jimicsiga jirka ee beerka waxayna jidka u dhigtaa sidii loo horumarin lahaa bartilmaameedyo cusub oo lagu daweeyo cudurrada beerka.● Xeerarka muujinta hidda
Xeerarka tibaabinta hidda-wadaha ee hepatocytes wuxuu muhiim u yahay joogtaynta beerka - Hawlaha Gaarka ah. Farsamooyinka sida isbedelka iyo Crispr - Cas9 Cas9 Teeficadaha hiddaha ayaa loo shaqaaleysiinayaa inay wax u bartaan qaababka tibaabinta hidda-wadaha oo ay cadeeyaan hidde-wadaha ku jira cudurada beerka iyo dheef-shiid kiimikaadka daroogada.Farqiga u dhexeeya aasaasiga iyo mid kale ee hepatocytes
● Aasaasiga vs. hepatocytes-yada aan dhimanayn
Heerka hepatocytes-ka aasaasiga ah waxaa lagu gartaa khadadka unugyada ee aan dhimanayn ee ugu horreyntii ku tiirsan. In kasta oo khadadka unugyada aan dhimanayn ay bixiyaan fududeynta dhaqanka iyo cimriga dheer ee nolosha, badiyaa waxay u dhiman yihiin nooc dhameystiran oo beerka ah - howlo gaar ah, oo sareeya ah● Vivo vs. Farqiga vitro
Daraasadaha vitro ee isticmaalaya hepatocytes-ka aasaasiga ah waa in lagula xisaabtamo kala duwanaanshaha loo arko inta u dhexeysa vivo iyo xaaladaha vitro. Kala duwanaanshahaasi waxay saameyn ku yeelan karaan soo-saaridda tijaabada ee xaaladaha jir ahaaneed ama cudurada guud, iyagoo ku nuuxnuuxsanaya baahida loo qabo farsamooyinka dhaqanka ee hal-abuurka leh ee si ka wanaagsan u dhex dhaca jawiga vivo.Hepatocytes-ka aasaasiga ah ee qaabeynta cudurka
● Qaabeynta cudurrada beerka
Heepocytes-ka aasaasiga ah waxay muhiim u tahay qaabeynta qaabaynta cudurada beerka, oo ay ku jiraan cagaarshow, crhohosis, iyo kansarka beerka. Markaad dib ugu soo celiso xaaladaha cudurka ee cudurka vero, cilmi baadhayaashu waxay baran karaan horumarka cudurka waxayna tijaabin karaan waxqabadyada daaweynta ee suurtagalka ah, iyagoo hormarinaya fahamkayaga cudurada beerka.● Fahamka hepatocyte - cudurada laxiriira
HEPATOCYTE Dysfunction waa xudunta cudurada badan ee beerka. Barashada hepatocytes-ka aasaasiga ah waxay siisaa aragtiyo ku saabsan farsamooyinka sida ku xusan cuduradan, fududeynta horumarka calaamadaha baarista iyo istiraatiijiyadaha daaweynta ee cusub.Caqabadaha iyo xaddidaadaha ee cilmi baarista hepatocyte
Arimaha waxqabadka iyo waxqabadka
Caqabadda koowaad ee cilmi baarista hepatocyte cilmi baarista ayaa ah in la ilaaliyo suurtogalnimada unugyada iyo shaqeynta waqti ka dib. Awoodda xadidan ee xadidan ee hepatocytes-ka aasaasiga ah ayaa loo baahan yahay in la isticmaalo farsamooyinka dhaqanka casriga ah iyo qaababka warbaahinta si loo ballaariyo cimrigooda iyo ilaaliya shaqadooda.● Xaddidnaanta muddo dheer - dhaqanka dhaqanka
Long - Muddo intaan Dhaqanka Dhaqanka Aasaasiga ah ayaa weli ah caqabad weyn, maadaama hepatocytes ay u muuqdaan inay lumiyaan beerkooda - astaamo gaar ah waqti ka dib. Daraasad joogto ah ayaa diiradda lagu saarayaa horumarinta nidaamyada dhaqanka ee taageeraya waqti dheerTilmaamaha mustaqbalka ee cilmi baarista hepatocyte
● hal-abuurnimada tikniyoolajiyada 'Hepatocyte'
Goobta cilmi baarista hepatocyte ayaa si dhakhso ah u horumarinaysa, oo ay wataan horumar tiknolojiyad iyo qaabab hal-abuur leh dhaqanka iyo falanqaynta qolka. Teknolojiyada 'Furning', aaladaha microfluidic, iyo sareeya - Qaababka baaritaanka baarista ee wax soo saarku waxay ka mid yihiin hal-abuurka ballaarinta codsiyada hepatocyte aasaasiga ah.● Awoodda codsiyada dawooyinka ee shakhsiga ah
Heerka hepatocytes-ka aasaasiga ah wuxuu qabtaa ballan qaad ah oo loogu talagalay dawooyinka shaqsiyadeed, gaar ahaan ku-habboon dawooyinka dawooyinka ee bukaanka shaqsiyaadka ee ku saleysan astaamahooda dheef-shiid kiimikaadka qaarada qaaska ah. Mustaqbalka cilmi baarista hepatocyte waxay ku taal isku-darka isku-darka galmada, heerka sare, iyo xogta dheef-ga si loo gaaro xeelado daaweyn oo shaqsiyadeed iyo wixii ka dambeeya.Gunaanad: Doorka Muhiimka ah ee Horpocytes iyo Hordhac shirkadeed
Hagaha hepatocytes-ka aasaasiga ah ayaa ah aaladaha lagama maarmaanka u ah dawooyinka cilmi baarista biomedical, daahfurka daroogada, iyo dawada dib-u-cusboonaysiinta. Caqabadaha socda iyo hal-abuurka ka jira cilmi baarista hepatocyte waxay muujinayaan muhiimadda xasaasiga ah ee unugyadan oo ka dhawaajiya howlaha adag ee beerka iyo horumarinta caafimaadka aadanaha.Waxay xaruntiisu tahay North Wales, Pennsylvania,IphageBiosciens waa mid takhasus leh, cusub, iyo hal-abuurnimo sareyso Aqoonta ballaaran iyo jacaylka cilmibaadhista sayniska, ipasse waxaa ka go'an inay soo bandhigto realgilo bayoolojino bayooloji oo tayo leh oo adduunka oo dhan ah, oo ka caawiya cilmi baaro-ka-qaadida gaarista ujeeddooyinkooda sayniska ee ka badan 2,000 oo nafsi ah.
Waqtiga Post: 2024 - 12 - 09 10:22:21