Guri Qof Gine IPhose bini-aadamka Cyp3A4 + RESTASE

IPhose bini-aadamka Cyp3A4 + RESTASE

Sharraxaadda Gaaban:

Dib-u-soo-celinta Cyp450 Enzymes-ka CypyMes waxaa lagu helaa injineernimada hidda-wadaha ee Cyp450 oo lagu muujiyey E. Coli ama unugyada cayayaanka. Shakhsi ahaan Cyp450 Isockyme waa la muujiyaa oo la daahiyaa, loona isticmaalaa in lagu isticmaalo dheef-shiid kiimikaad daroogada, dheef-shiidka daroogada plomymorphism iyo is-dhexgalka dheef--dheellidda daroogada. Noocyada Noocyada Dheef-ka-dheellitirka daroogada ayaa lagu qori karaa iyadoo isbarbar dhigaya The Plate of Messabolis ee musharixiinta daroogada by beerka Cym450 enzymes.

Hadda la xiriir Kudar gaadhiga wax iibsiga

Si faahfaafo

Calaamadaha wax soo saarka

Dhex qori

N / a

Qeybta:
Dib-u-dhigid
Shayga no.:
0161A1.09
Cabbirka Unugga:
0.5ml, 0.5Nmol
Unugyada:
N / a
Noocyada:
Insaan ah
Galmo:
N / a
Xaaladaha kaydinta iyo gaadiidka:
Kaydso AT - 70 ° C. Baraf qalalan ayaa la keenay.
Nidaamka Imtixaanka:
Dib u soo kabashada Cym450 enzymes
Baaxadda Codsiga:
Dheecaannada dheef-shiidka daroogada ee vitro

Hore: IPhepape bini-aadamka Cyp3A4 + RESTACE + B5

Xiga: IPhose Aadanaha Cyp2E1E1 + RESTASE

IPhose bini-aadamka Cyp3A4 + RESTASE

Sharraxaadda Gaaban:

Si faahfaafo

Calaamadaha wax soo saarka

Iphape bakayle (New Zealand White) PBMC, cusub

IPhope unugyada kopupffer ee caadiga ah ee bini-aadamka

Rephage eyga (beagle) plasma, oo ah tabaruc keli ah, dhedig, sodium sodium

Mouse (ICRN / ACD - 1) Plasma, Jinsiga Isku-dhafka ah, sodarin sodium

Iphase daanyeerka (cynomolgus) pancrials nudaha, lab

Iphase daanyeerka (cymomolgus) sambabka