Deganaanshaha Lysosomal: Waxyaabo muhiim u ah waxqabadka The The The The The The The The The The Thring

Furayaasha-Sirna, si gaar ah, Sirna, Sirna baxsashada, Hepatocyte Lysosomes, Twitosome, Lysosomal acid acid

Alaabada iphepape 

Gogoldhig

Horumarinnada Baydhaptics waxay kaxeeyeen isbedelka labada antiboss - In kasta oo bartilmaameedyadooda iyo farsamooyinka kala duwan ay jiraan, labada ADC iyo Sirna waxay u habeeyaan si aad ah ugu tiirsanbeerka lysosomedeegaan, meeshaXasiloonida LysosomaliyoLysosome-ka LiiskaCiyaar doorka muhiimka ah. Nidaamka ADC, qaboobaha saxda ah eeAdc conger by Cathepsin b- si gaar ah ds8201A iyoGGFG - DXDAstaamaha-ayaa hubiya in la xakameeyoSiideynta lacag bixinta. Loogu talagalay daaweyn Sirna, ka gudubka caqabadda Lysosomal waxay muhiim u tahay wax ku ool ahSiriyaha SirnaiyoSirina baxsashada, gaar ahaan isticmaalkaGalnac-SirnaWaxay ku dhacdaa bartilmaameedkaashepatocyte lysosomes. Dukumintigan isku dhafan ayaa ku eegaya wadooyinkan guud iyo caqabadaha.

1. ADC Dulmar guud iyo Fikradaha Muhiimka ah

ADC waa daawo dameero ah oo isku dareysa antibody-ka monoclonal, mushahar sareeya, iyo xariirka ADC. Khadkan Adc waxaa loogu talagalay in lagu hubiyo siideynta mushaharka qaaliga ah, buro ku-meel-gaar ah - Antigens gaar ah inta uu ilaalinayo unugyada caafimaad qaba. Siidaynta lacag bixinta ee la xakameysay waxay dhalleeceyneysaa ku tiirsan beerka jawiga dhagaxa, halkaas oo xasilloonida sare ee Lysosomal ay u sahleyso catabolis-ka wanaagsan ee Leysosome. Goobtan, Cathepsin B ayaa ku shaqeynaya xilliga saxda ah si loo dhexdhexaadiyo xariiqda xariifka ah ee ADC. Tusaale ahaan, DS8201A ayaa ka shaqeysa GGFG - Habka DXD ee lagu gaaro sii deynta mushaharka ee lala beegsanayo si gaar ah ee beerka Linsosome, iyadoo la hubinayo labada ficil ee wax ku oolka ah iyo sunta nidaamsan.

ADC Lingger iyo qaababka bixinta mushaharka

Naqshadeynta xirka shirkadda ADC waxay muhiim u tahay hubinta siideynta lacag bixinta ee la xakameeyay. Xasiloonida LEABLY TESPLENTY waxay saameyn ku yeelanaysaa xaaladaha ku dhex jira beerka Lonsosome, halkaas oo xasilloonida Lysosomal ay door muhiim ah ka ciyaarayaan. Linsolme deggan ayaa fududeeya catabolism wax ku ool ah ee loo yaqaan 'lysosome', oo laga hubinayo in enzymes sida cathepsin b uu si hufan u socodsiin kara ADC. Xaaladda siideynta mushaharka, daboolka ADC waa inuu ahaadaa mid kacsan inta lagu jiro wareegga oo kaliya lagu dhejiyo gelitaanka beerka ee Linsosome. Kala-baxaan waxaa dhexdhexaadinaya cathepsin b, oo muhiim u ah kicinta catabolis-ka Lysosome. Intaa waxaa dheer, nidaamyada horumarsan sida DS820A iyo GGFG - DXD waxay si buuxda uga faa'iideysataa beerka jawiga Linesome, oo kor u qaadaya labadaba Sharafta Linked iyo Sii-deynta ee ADCOme inta ay sii wadida xasilloonida Lysosomal.

Ka sokow Cathepepsin B, oo kale oo lagu garto cysteine-ka ah sida cathepsin l, cathepsin m, iyo cathepsin k waxay si aad ah ugu tabaruceen siideynta Lysosomal iyo daroogada. Cathepsind l si weyn ayaa loo aqoonsan yahay howlihiisa ciribtirka leh ee xayndaabkiisa iyo doorkeeda borotiinka is-hoosaadka intracellular-ka, taas oo taageeraya siideynta lacag bixinta ee waxtarka leh. Sidoo kale, cathepsinm, in kasta oo si weyn loo gartaa si weyn loo gartaa, waxay ka qeybqaataa catabolis-ka Lysosomal waxaana laga yaabaa inay dhameystiraan waxqabadka kale ee la xiriira. Cathepsin k, oo ugu horreyn lagu yaqaan howlaheeda isxusha ee dib-u-soo-celinta lafaha, ayaa sidoo kale baabi'in kara xiriirada loo yaqaan 'pept' xaaladaha qaarkood. Isku-darka iyo mararka qaar waxqabadka magdhowga enzymes-kan ee enzymes-kaan ayaa ka caawiya in xiriiriyeyaasha ADC iyo qaababka saadaalinta ee laxiriira ay si yaryar u xidhnaato si ay ugu dhaqaaqaan daweyn si isdaba joog ah unugyada bartilmaameedka ah. Baadhitaan dheeri ah oo ku saabsan is dhexgalka ka dhexeeyo Cathepsin B, cathepsin l, cathepsinm, cathepsin k ayaa shaaca ka qaadi kara istiraatiijiyado cusub oo loogu talagalay naqshadaynta iskuxirka si kor loogu qaado guud ahaan si waxtar u leh waxtarka.

2. Daawooyinka Sirna iyo caqabadaha gaarsiinta

U-gaarsiinta Sirna iyo gogosha Lysosomal

Daawooyinka Sirna waxay bixiyaan qareen sare oo ku saabsan aamusnaanta hidda-wadaha; Si kastaba ha noqotee, caqabad weyn ayaa hubinaya in Sirna uu ka badbaaday xaalufinta. Ka dib EdocyTosis ka dib, jajab weyn oo Sirna waa laga ganacsadaa loo yaqaan 'Sirna' laga ganacsadaaLysosomal acid acid phosphatuse-Caro-soo-nooleynta xasilloonida Lysosomal iyo waxay u horseedaa xasiloonida Sirna.

Habka Galnac-Sirna waxay ku dhacdaa

Galnac-Sirna waxay ku kacdaa sahlayda sicirka Sirna iyadoo la beegsanayo soo-celinta astielogycoprotein ee hepatocytes, kaas oo kor u qaadaya raaxada degdegga ah ee endocytosis. Mar haddii lagu dhex galo, isku-darka waa in laga adkaadaa caqabadaha Lysosomal si ay u suurtogeliyaan baxsashada Sirna wax ku oolka ah. Wax ka badalida kiimikada sida 2'-f, 2'-ome, iyo kooxaha fosfooraska fosfooraska ah waxay hubiyaan in Sirnadu ay weli ku adkeysaneyso jawiga adag ee beerka lysosome.

Nidaamka cilmi baarista dheef-shiid kiimikaadka iyo xulashada oligoncleotatides

Sida daroogada yaryar ee moleule-ka yar yar, qaababka Sirna waxay u baahan yihiin kuwo dhammaystiran oo ku jira daraasadaha xasilloonida dheef-shiid kiimikaadka bateska ee vitrolic-ka inta lagu gudajiro horumarka hortiisa. Daraasadahaani waxay qiimeeyaan saameynta ay catabolis-ka Lysosome iyo doorka Fosphatase acid ee Lysosomase ee sharaf-xumada ee Sirna ee ku dhex jira beerka ee Lysomes iyo Hepatocyte Lysosomes. Adkeynta waxaa la saarayaa iyada oo la eegayo si loo gaarsiiyo Sirna iyo hubinta inay baxsato sirina. Nidaamyo tijaabo ah oo kala duwan - sida beerka isku-darka beerka, lysotomes beerka ee go'doonsan, iyo hepatocytes-ka koowaad - waxaa loo shaqeeyaa si loo yareeyo jawiga hepatic. Kobcinta xasilloonida Lysosomal iyada oo qiimeeyahan ah ay fure u tahay hagaajinta waxqabadka daawooyinka Sirna.

3. Doorka guud ee loo yaqaan 'manstosomes-ka kalluunka

Beerka lysosome

Istaraatiijiyada ADC iyo SIRNbaba waxay isku xirtaan beerka Lysosome-waa gole muhiim u ah dhaqdhaqaaqa maandooriyaha iyo nabaad-guurka. Nidaamyada ADC, beerka Lydsome wuxuu fududeeyaa siideynta mushaharka ee la xakameynayo ee ka baxsan Cathepsin B-dhexdhexaadinta Connect Cheavage. Daawooyinka Sirosa, beerka Lysosomes (iyo hepatocyte lysosomes) waxay soo bandhigayaan caqabad ka mid ah catabolis-ka xun ee Lysosome-ka ah ee Lysosome-ka ah ee Lysosome-ka ah ee Lysosome-ka ah ee Lysosome acid acid acid acid ah. Markaa, dayactirka xasilloonida Lysosomal ee sare ayaa fure u ah hubinta catabolis-ka wax ku oolka ah ee Lysosome ee loo soo celiyo labadaba ee la xakameeyay ee ADC ee la xakameeyay iyo si hagaajinta Sirna.

Moodooyinka cudurka jimicsiga iyo nidaamyada cilmi baarista

Si aad wax u barto labadaba sii deynta ADC iyo xasilloonida Sirna, cilmi baadhayaashu waxay u isticmaalaan dhowr mooto ah.TwitomeMoodeel-sida Thesosomes-ka beerka ee loo yaqaan 'the therosomes-ka' ee jiirka 'perosomes'-keega Intaas waxaa sii dheer, nidaamyada cilmi baarista dheef-galka ah oo ay ku jiraan jajabyada beerka, beerka isku-darka beerka, iyo hepatocytes beerka, iyo hepatocytes-ka go'doonsan, iyo hepatocytes-ka ee go'doonsan ayaa ka caawiya sii deynta mushaharku iyo sida si hufan Sirna ay ka baxsato xaalufinta. Moodooyinkaani waxay muujinayaan muhiimadda ay leedahay in la habeeyo catabolis-yada Lysosomes iyo Fosphatuse Fomphatuse in la joogteeyo howsha ugu habboon ee beerka Lindesome.

4. Istaraatiijiyadaha Dhex-dhexaadka ee Natiijooyinka lagu xoojiyey

Guusha daweynta ADC iyo Sirna daroogooyinka Sirna waxay kuxirantahay modurdalka xasilloonida Lysosomal iyo xakameynta catabolism-ka Lysosome. ADCCS, Daaweynta naqshadda Linked ee ADC iyo Hubinta Qalalaasaha Cagagaga ee Cathepsin B (sida lagu muujiyey gudahaDs820aiyo GGFG - Nidaamyada DXD) waa muhiim. Daawooyinka Sirna, wax ka badalida kiimikada ee Galnac-Sirna waxay ku dhacdaa iyo istiraatiijiyooyinka si loo yareeyo waxqabadka loo yaqaan 'phosphatsase acid acid' ee loo yaqaan 'phosphatase acid acid' waxay ka caawisaa hagaajinta u gaarsiinta Sirna iyo Sirna baxsashada. Qaab isku dhafan oo tixgeliya jawiga gaarka ah ee beerka Lysosome ayaa muhiim u ah gaarista waxtarka daweynta sare ee sare.

Gabagabo

Labada daawada ee ADC iyo Sirna waxay la kulmaan caqabado caan ah oo ku dhex jira beerka jawiga LandosOme, halkaas oo xasilloonida Lysosomal iyo catabomes-ka Lysosomes-ka ee Lysosome ay go'aamiyaan guusha ay gaareen. Nidaamyada ADC, gaar ahaan DS820A iyo GGFG - DXD, ku tiirsanaanta xariifka xariifka ah ee ADC ee Cadhada TheAVEsin b by cathepsin b by si loo sii daayo mushaharka mushaharka ee waxtarka leh. Sidoo kale, gaarsiinta Sirnac-Sirna connacna connates waa inay ka adkaataa xannibaadda 'Lysosomal' iyo nabaad-guurka by fossosomase acid acid-ka ee loo yaqaan 'reysosomase acid' si loo gaaro baxsiga Signa wax ku oolka ah. Anigoo ka fadhiya moodooyinka cudurka vitro lonosomes iyo jajabyada beerka iyo qaadashada istiraatiijiyadaha isku-dhafan ee dhaqdhaqaaqa dhalmada ee LandosOmal, cilmi-baarista labadaba ee ku saabsan spanamics-ka inta ay yareynayaan damida - saameynta bartilmaameedka iyo sunta astaanta.