Aikin ADC ya shiga tsakani ta Cathepsin B a DS8201A da GGFG - Tsarin DXD

Shigowa da

Antibody - Magunguna Conjugates (ADCs) sun fara fitowa a matsayin aji na juyin juya halin cutar kansar da ke hada kayayyakin maganin montocox tare da karfin Cytotoxic na Chytotoxic na Chytotoxipy. Ta hanyar ɗaukar ƙwayar cuta - Tarwatsa antibody, wanda ba zai iya ɗaura mai amfani da cutar kansa ba yayin rage lalacewar ƙwayoyin cuta.

Hanyar ADCs da rawar da Cathepsin B

An tsara AdCs don ƙara wakilan Cytotoxic don sel sel ta ɗaure ƙwayoyin cuta - Tsarkakewa Antigens. Da zarar an ɗaure shi, ADC tana da ciki ta hanyar maimaitawa - Aretortorososis da fataucin cutar asirin, inda aka fito da miyagun ƙwayoyi na cytotoxic. Ofaya daga cikin manyan abubuwan enzymes da hannu a cikin wannan sakin shine Cathepsin B, tsallake cysteine ​​cysteine. Cathepsin B ya taka muhimmiyar rawa a cikin tsabtace peptide - masu haɗin yanar gizo a cikin AdCs, yayin rage ingantaccen guba.

DS8201A: ADC ADC

DS8201A, kuma aka sani da [FAL - TRATUZUMB DUREXTectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectectecan - NXki], shine Herc wanda ya nuna abin ban mamaki a kula da Hiyayi2 - Mashahurin cutar kansa ta kai da kuma sauran tazanta. Ya ƙunshi trastuzumab - da aka samo shi da alaƙa da mai ƙarfi na mai ƙarfi na mai ɗaukar hoto na inhiisrasomase i inawar payer ta hanyar rufewa. Wannan ADC tana da babban miyagun ƙwayoyi - zuwa - Attory rabo (Dar) idan aka kwatanta da a baya her2 - Aiwatar da AdCSED da Inganta Cancer. DS8201A shima ya san shi ne sananne ga abin da ya yi, yana ba da izinin biyan kuɗi don haɓaka kuma kashe sel maƙwabta ba tare da la'akari da magana ta Her2 ba.

Ggfg - dxd: mai kirkirar mai lilin a DS8201A

Babban abu a cikin nasarar DS8201A shi ne keɓaɓɓen mai lilin, GGFG - DXD. Wannan peptide na ainihi yana dauke da Glycine - Glycine - PhenylalayLanine - Glycine (Glycine) Motif, wanda aka samar da shi sosai a cikin sel sosai a cikin sel sosai. An tsara na mai rufin GGFG don inganta kwanciyar hankali a wurare dabam dabam yayin tabbatar da sauri da saki saki na cytotoxic a cikin ƙwayar cytotoxilod.

Ƙarshe

AdCs kamar DS8201A wakiltar canrigm a cikin cutar kansaer magani, bayar da niyya isar da niyya mai ilimin kimiyyar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa ne. Matsayin Cathepsin B a cikin keɓaɓɓen clhevage, sabuwar hanyar ggfg - Tsarin dxd linzami, da babban inganci na DS8201A tare da haɗuwa da ci gaba a cikin fasahar AdC. Kamar yadda ake ci gaba da hauhawar AdC, cigaba da inganta hanyoyin haɗin yanar gizo, biya, da kuma niyya maganin rigakafi zasu sa hanyar don samun ingantacciyar hanyar inganci da keɓaɓɓen cutar kansa.

Keywords: Keyc linc link, biya saki, hanta lysosome, lysosomal kwanciyar hankali, lurshesoome catabolism, cathepsin b, ds8201A, GGFG - DXD