ADME
Lokacin yin nazarin magungunan magunguna, dole ne a bayyana wani muhimmin sashi na kimantawa na pharmacological preclinical, adsorption, rarrabawa, metabolism, da haɓaka (ADME) kaddarorin dole ne a haɓaka yayin haɓakar ƙwayoyi. Metabolism na miyagun ƙwayoyi, ko biotransformation, yana nufin tsarin da miyagun ƙwayoyi ke yin sauye-sauyen tsarin sinadarai don sha da kawarwa a cikin jiki. An raba shi zuwa metabolism na lokaci na I & II, biotransformation yafi faruwa a cikin hanta, wata gabobin da ke wadatar da enzymes na rayuwa, da kuma a cikin wasu gabobin kamar hanji, koda, huhu, jini, da fata.
Makullin, hadaddun al'amari game da metabolism na miyagun ƙwayoyi shine haɓakar binciken don kafa alaƙa don tsinkayar halayen ƙwayoyi na rayuwa a cikin ɗan adam, ingancin ƙwayoyi da aminci. A cikin 'yan shekarun da suka gabata, IPHASE ya haɓaka samfurori da yawa don nazarin maganin ƙwayar cuta ciki har da kwanciyar hankali na rayuwa, phenotype na rayuwa, hana enzyme (IC)50). Bugu da ƙari kuma, IPHASE kuma yana ba da samfura masu amfani a cikin - vitro samfuri irin su hepatocytes na farko, hanta da microsomes na hanji, S9 fraction, cytosol, CYP recombinases da aka tattara daga takamaiman nau'ikan a jihohi daban-daban.