5α - Rajista na Aiwatar da Aiwatarwa: SRD5A1 & SRD5A2 don Gudanar da Sebum a cikin ilimin kwastomomi

Keywords: Nau'i 1 5α - RAGORE, TITA 2 5α - RAYUWAN,5α1, 5α2, SRD5A1, SRDTA2,NADPH, 5α - Ayyukan Redomase, 5α - RAYUWAR CIKIN SAUKI, DHT).

Kayayyakin iphayan

Shigowa da

5α - RAHU RAYBAYUSI NE MORYME ne da ke da alhakin Canza Tesposterone cikinDhydrotesstoterone (dht), wani fasali da karfi da kuma. Wannan martani shine Nadph - Dogaro, yana buƙatar adenine na NicotinamideAbincin cinyoyin cinyoyin civesothide (Nadph)a matsayin coackor. Dht yayi biris ga Androgen masu karɓa da babbar dabara fiye da na Testosterone kuma yana da mahimmanci wajen haɓaka ayyuka daban-daban na ilimin jiki, ci gaban gashi, da kuma ayyukan gargajiya.

Isoenzymes: Type 1 5α - RAWANE & Type 2 5α - RAYUWARSA

Akwai manyan manyan isoenzymes guda biyu na 5α - RAHOCKETE:

• -Nau'i 1 5α - RAYUWA (SD5A1): Da farko an bayyana a hanta, fata (musamman sebaceous gland), da fatar kan mutum. Wannan neforram yana taka muhimmiyar rawa a cikin metabolism na Androogen kuma yana da alaƙa da tsarin sebum.
• -Nau'in 2 5α - RAYUWA (SRD5A2): An samo galibi a cikin prostate, bitar Seminal, da fata na gaske. Kodayake ayyukan ta ya fi alaƙa da kyallen takarda haifuwa, yana kuma taimaka wa yanayin fata a wuraren da ake hankali.

Rawar dht a cikin samar da sebum

DHT yayi biris ga Androgen rarewa a cikin sebaceous gland, motsa sebocyte yaduwar yaduwar sebocyte da sebum. Ordproductioncheting na sebum na iya rufewa pores, ƙirƙirar yanayi mai dacewa ga kayan kwalliyar kayan sanye, kumburi, da kuraje. 5α - Nau'in Rauracewa 1 (404), kasancewa mafi rinjaye a fata a fata, saboda haka ne ke mayar da hankali ga tsarin kwaskwarima da ke nufin rage rage sebum - matsaloli masu alaƙa.

Kimantawa 5α - RAYUWAR SAUKI: Ayyukan Aiwatarwa

Don haɓakawa da haɓaka kayan kwalliya na kwaskwari waɗanda ke hana 5α - Rajista, masu bincike sun dogara da ayyukan ƙamus ɗin da suke auna ayyukan enzyme waɗanda suke auna ayyukan enzyme waɗanda suke auna ayyukan enzyme. Guda biyu na mafi yawan hanyoyin bincike sune Spectrophotometry da ruwa na chromatography - Mul spectrometry (LC - ms).

Spectrophotometric Assay

Wannan hanyar tana lura da iskar shawa da haduwa, wanda ke tare da rage tasirin tessidosterterone zuwa DHT ta 5α - RAYUWAR. Kamar yadda Nadph ta cinye lokacin da enzymatic dauki a cikin enzymatic hearchance, halayyar ta sha a 340 nm yana raguwa, yana ba da izinin ainihin matakan.5α - Ayyukan Red.

• - Abvantbuwan amfãni: Ara, farashi - Inganci, kuma ya dace da babbar - allon allo.
• - Iyakoki: Bai yi daidai da Dht ba, saboda haka yana iya rinjayar halayen halayen ko kuma immuritiuss a cikin ruwan 'yan itace.

Lc - ms assay

LC - ms (ruwa cromatography - Mass spectrometry) yana ba da takamaiman takamaiman ma'aunin dht daga testosterone. An raba cakuda dauki cakuda ta hanyar Chromatography, sannan gano da ƙididdigar amfani da taro na farko.

• - Damars: babban hankali da takamaiman hankali, ma'aunin kai tsaye na substrate (Testosterone) da samfurin (DHT), yana ba da damar tabbatarwa5α - RAYUWAR CIKIN SAUKI.
• - Iyakoki: Mafi hadaddun da tsada; Yana buƙatar kayan aiki na ƙwararru da ƙwarewar fasaha.

Waɗannan hanyoyin da ke cikin asasi ne a cikin allo da ci gaban kayan shafawa waɗanda ke nufin daidaita samar da sebum ta hanyar yin amfani da ayyukan Sebum na Sebum na Sebum.

Aikace-aikacen Masana'antu: Gudanar da Sebum ta hanyar hanawa

Masana'antar kwaskwarima ta amince da shi 5α - RALCKEDINA CIKIN SAUKI A CIKIN SAUKI CIKIN SAUKI, kuraje, da kuma abubuwan da suka shafi rashin lafiyar da suka shafi fata. Ta hanyar samar da samfuran da ke raguwa da yawa waɗanda ke rage 5α - Ayyukan Redawa, samfurori suna nufin daidaita matakan sebum da inganta fuskar fata.

Sinadaran kayan kwalliya na gama gari tare da 5α - Raurrasashen ƙwararrun kayan ƙara sun haɗa da:

• - Zinc pca
• - Garge shayi na kore (epigallatechinchin
• - Sayan Palmettto Cire
• - Puman iri mai
• - Azelac Acid

Wadannan ayyuka masu aiki ta hanyar hana sd5A1 (5α1) da / ko SRD5A2 (5α) Farashin isoflks, ta haka ne rage matakan fata na fata kuma saboda haka yana rage ƙwayar ƙwayar ƙwayar cuta. Wannan yana tallafawa yadda ƙa'idodin 54 - Rappatesewararrun hanawa sun fassara yadda aka gabatar da su sosai daga kimiyyar kiwon lafiya a cikin yau da kullun.

Ƙarshe

The enzyme, musamman ta hanyar ta 5α - Musamman na eptactase 1 (SDD5A1) Iflorm, yana taka muhimmiyar rawa a cikin tsarin samar da sebum ta hanyar dht. Rashin daidaituwa masana'antar ta kwaskwarima na 5α - Rapptasewararren hanawa, inganci ta hanyar Spectrophotometric da LC - MS Hards, yana wakiltar kimiyya da fata. Kamar yadda bincike ya ci gaba, wannan enzyme ya ragu a kan gaba na ci gaban Dermocrinics, yana ba da rata tsakanin endocrinology da kuma ingancin fata.