Baya
Ta hanyar halayenta na fasaha na musamman, maganin Sirna ya zama mai kula da sabon binciken ƙwayoyin cuta da ci gaba a cikin 'yan shekarun nan, kuma shine ɗayan mafi saurin tasirin geraries a halin yanzu. Idan aka kwatanta da ƙananan kwayoyi na gargajiya da magunguna na rigakafi, magunguna masu sauri, ba sauki don kawowa da kwayoyi masu amfani da kwayoyi "a waje na ƙira na uku na magunguna. Na uku masarar magunguna ban da ƙananan kwayoyin kwayoyin da kwayoyi masu ƙwayoyin cuta.
Koyaya, a matsayin sabon aji kwayoyin kwayoyi, magunguna na Sirna sune Polar, an cajin su, kuma don haka magungunan magunguna, wanda ke da sabon kalubalanci don farkon cigaban magunguna.
Gabatarwar Magungunan Sirna
Magungunan sirna, kuma ana kiranta da oligogondses (ons), suna nufin magani - a shirye OligoDides yawanci 18 - 30 nt a tsawon. Small RNA Drugs include small interfering RNA (siRNA), Antisense oligonucleotide (ASO), microRNA (miRNA), small activating RNA (saRNA), messenger RNA (mRNA), Aptamer, and Antibody-oligonucleic conjugates (AOC).
Binciken na yanzu yana mai da hankali kan nau'ikan magunguna uku na Sirna: ASO, Sirna da Aptam. Daban-daban Oligootides suna da hanyoyi daban-daban na aiki, kuma suna taka rawar da ke hana su a matakai daban-daban na Pathogenesis. ASO da Sirna suna aiki a matakin da aka yi niyya Mna; Aptamer kai tsaye yana hana ayyukan sunadaran da ke da hannu a cikin Pathogeneneis. Batunsu na kowa shine cewa sun shiga tsakani cikin bayyanar kwayoyin halittar don cimma manufar magani.
Gabaɗaya, na musamman Hanyar magunguna na acid sa ƙananan abubuwa masu yawa: Magungunan ƙwayoyin cuta, da yawa na ƙwararru, da kuma babban sakamako na cigaba, da kuma babban nasara na cigaba da ci gaba, wanda Ana ɗaukarsa azaman ƙarni na uku na fasahar kirkirar Pharmaceututical mai mahimmanci wanda zai inganta canjin masana'antar magunguna bayan ƙananan kwayoyin kwayoyi da magungunan rigakafi. More da sauran kamfanonin magunguna sun saka hannun jari a cikin ingantaccen bincike da ci gaban magunguna na Sirna.
Matsayin ƙananan ƙwayoyin ƙwanƙwasa ƙwanƙwasa ƙwanƙwasa a kasuwa
Amincewa da ƙananan ƙwayoyin acid na acid:
- Antise Oligowides (ASOS): Waɗannan guda - tsinkaye DNA ko RNA Curcures ga takamaiman fassarar fassara ko gyara splicing. Sanarwa ASOS sun hada da:
- Nusineren (Spinrada): An yarda da Kogrouly na kasusuwa.
- Etoplirsen (Offundys 51): Ya kai hari dystrophy dystrophy.
- Inotersen (Tegitedi): yana bita treditary transthydin - Adireshin Amyloidis.
- Smallan ƙaramin rnas (Sirnas): sau biyu - Matsa RNA kwayoyin da ke inganta lalata da MRNA.
An amince da sojojin Sirna sun hada da:
- Patisiran (Onpattro): FAR FAR FARKO - An yarda da maganin Sirna, yana magance abadin gado - Adireshin Amyloidis.
- Givosian (Givlari): don m porphonesa.
- Lumasiran (oxlule): yana nuna nau'in nau'in hyperoxaluria 1.
- Aptamers: gajere, tsarin acid na makaman nucleic wanda ke ɗaure ga takamaiman sunadarai.
- Pegaptanib (Macuten): An amince da Aptamer da aka amince da shekaru - Mai alaƙa da Macular.
Keywords: Galnac - Sirna, Isarwar Sirna, Lysososomes Lysosomes, Tritosome, Lossoosome Catabolism, Losososomal Catabolism, Lysosomal Catpholism, Lysosomal Catphatase
Lokaci: 2025 - 04 - 09 10:04:06