Masu sufuri da kuma aikinsu a cikin ilimin magunguna

Sufuri da aikinsu

Masu jigilar kayayyaki suna da babban rabo na sunadarai waɗanda spin sel membrane na kwai da yawa kuma suna taka muhimmiyar rawa wajen sarrafa nassi (a zahiri faruwa a cikin kwayoyin) da abubuwan da suka faru (ƙasashen waje). Wadannan mahimman membrane sun kasance suna da ƙoshin kwadago don daidaita yanayin salula na ciki ta tabbatar da cewa ana iya amfani da ƙwayoyin guba, sau da yawa a kan gradi da hankali. A cikin mahallin hanyoyin sufuri na magunguna "gabaɗaya suna nufin waɗancan sunadarai waɗanda ke amfani da takamaiman hanyoyin da zasu motsa wakilan warkewa a fadin shingen ilimin halitta. Manyan iyalai biyu sun mamaye wannan tsari: ATP - Superfamily da Solge Carrfamily da Masarauta (SLC) Superfamily.

ABC aufare: ATP - Fitar da masu tsaron ƙofa

Masu jigilar kaya na AbC sune masu aiki na farko waɗanda ke da ƙarfi daga ATP Hydrates don motsa abubuwa da yawa iri-iri, har ma da manyan kayan salula. Hallmark na waɗannan hanyoyin sufuri shine ƙwararrun nucleotide - The Hydremyze ATP, da kuma kayan aikin da suka dace da su na zamani. Kogular su - Aikin aikinsu yana da mahimmanci ba kawai don kiyaye gidan salula da kuma shiga cikin wasan tsinkayar cututtuka ba. Misali, ta hanyar shawo kan sel na chemothera na rayayye daga sel na cutar kansa, da yadda ya rage juriya na warkewa da jagorancin yanayin warkewa (MDR).

Masu jigilar SLC: sun sauƙaƙe tsarin sakandare

Ya bambanta da jigilar kayayyaki na ABC, membobin mambobi na daskararru (SLC) Superfamily yawanci ba sa buƙatar kai tsaye atp hyp hypysis. Madadin haka, masu jigilar SLC suna aiki kamar yadda sakandare suke aiki ko kuma masu tallafawa. Suna cin amanar cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan lantarki na lantarki-sau da yawa suna haifar da UPP na famfo - don fitar da UPCOse, amino acid, neurotirnsmiters na kwayoyin halitta. Yawancin magunguna waɗanda ke da hydrophilic ko nuna ƙarancin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta hanyar waɗannan hanyoyin sufuri don aikin salula. Domin an kore su ta ion munshiyar maimakon ATP, sufuri na SLC yawanci suna bayar da ingantacciyar hanyar samar da takamaiman tsari da hanyoyin sufuri da magunguna.

Effulu Erplux InterSe Ustake: Gudummawar aiki

A cikin tsarin sufurin miyagun ƙwayoyi, wasu masu tallafi sun ƙirar don ƙwayar cuta, yayin da wasu suka sauƙaƙa ƙirar magani. Masu jigilar jigilar kayayyaki, galibi daga ABC na ABC, yi amfani da ATP Hydrolysis don cire mahadi daga sel. Wannan aikin yana da mahimmanci don iyakance sha a kyallen shinge da kuma kare gabobin da suka dace. Masu jigilar kayayyaki, galibi a cikin dangin SLC, suna ba da kwayoyi da kwayoyin halitta cikin sel, tabbatar da ilimin halittar su da kuma ba da damar yin amfani da ayyukan magunguna a shafuka. Tare, aikin da aka daidaita da shigarwa da masu jigilar kayayyaki da ke tattare da manufar plasma, da kuma kawar da bayanan martaba na warkewa, da hakan m.

Motsa sufuri da aikinsu

MDR1 (P - glycoprotein, abcb1)

A matsayina na daya daga cikin yadu na masu ba da gudummawar ABC, MDR1 (wanda aka fi sani da P - gp) galibi ana bayyana shi cikin kyallen takarda kamar hanjin, hanji, da kuma hanjin-kwakwalwar jini (BBB). Ta hanyar yin ɗora kwayoyi da Xenobiotiks daga sel, p - gp yana iyakance na kwayar cutar ƙwayoyin cuta na baka da kuma tabbatar da saurin kawar da tsarin juyayi. Aridically, GWAMNATI NA P - GP a cikin ciwace-ciwacen da ke da matukar bushara, wani kalubale wanda ke buƙatar ko amfani da masu ilimin ƙwaƙwalwa wanda ke buƙatar aikinsa. P - ikon yin jigilar kayan cike da rikitarwa na tsari - daga Anticanceran wakilan da ba a tantance muhimmancin kariya ba a cikin kwastomomi na kariya da proincepy da proincepy.

BSE (Bile Explump Pumma, Abcb11)

BSE ne hanta - Musamman ABC mai jigilar ABC wanda yake da mahimmanci don madaidaicin ɓoye billa acid daga hepatocytes cikin bile canaliculi. Wannan tsari yana da mahimmanci don narkewar abinci da kuma sha da abubuwan da ake ci da abinci da kuma kiyaye bile acid bilosasis. Rushewar aikin BSE - ko ta hanyar maye gurbi ko magani - Haƙurin son rai - na iya haifar da chelestasis, yanayin da yake haifar da kwarara. Chostates Ciki Karkanta na iya ci gaba zuwa mummunan hepatotoxicity, yin fasahar manufa mai mahimmanci don cin gaban shuki da kuma ci gaban masu shayarwa don magance yanayin cholesticics.

BCRP (nono kansa furote na asali, abcg2)

BCRP wani APTP ne ATP - Dogaro da jigilar kayayyaki wanda aka bayyana a cikin kyallen takarda kamar mahaifa, hanta, hanji, da kuma shingen-kwakwalwa. A cikin mahallin halartar miyagun ƙwayoyi, BCRP tana iyakance tsarin bayyanar da yanayin warkewa, gami da antotherapeuss, ta hanyar yin amfani da su daga sel. Tsarin dabarunsa cikin kyallen kyallen takarda yana taimakawa kare tayin da kwakwalwa daga Xenobiotiks. Fasali na kwayoyin cuta ko kuma nuna alama na BCRP na iya canza ƙwayar cuta da magunguna kuma an yi masa magana cikin juriya ga Chemorcy, sanya shi wani muhimmin abu a cikin keɓaɓɓen magani da magunguna na harhada magunguna da magunguna.

Mate1 / ME2 - K (Multidrug da Gaxrus da sunadarai masu tasowa)

Wadannan masu sufuri na selc superfamily kuma an bayyana da farko a cikin ramaki da kyallen takarda. Mate2 da MET2 - K Aiki a cikin haɗin gwiwa tare da mambarfin kayan jigilar kayayyaki na kwayoyin halitta (kamar Oct2 a cikin koda) don saka ishara da aka cire magunguna da gubobi. Ta hanyar fadakarwa cikin fitsari a cikin fitsari ko bile, wadannan sunadarai suna taimakawa wajen magance izinin magani da rage guba. Abubuwan da suka dace da su suna da mahimmanci don hana tarar miyagun ƙwayoyi, wanda zai iya haifar da abubuwan da suka faru da mugunta ciki har da nephrotoxicity.

Oatop1b1 (Annic Omin Shigarwa Pollypeptide 1b1, SLCO1B1)

Mafi yawanci aka bayyana a kan membrane na sinusoidal na sinusoidal, oatop1b1 mai jigilar jigilar kayayyaki ne na biyan kuɗi na kwayoyi, cututtukan kwayoyi, da wakilan maganin rigakafi, da kuma wakilan maganin anticicason, da kuma wakilan maganin anticicason, da kuma wakilan maganin anticianter. Wannan jigilar kayayyaki kuma yana taka rawar gani a cikin koda mahimmin mahimancin mahimman mahimmancin iyakokin kamar Bilirub, steriroid conjugate, da horar da thyroid. Bambance-bambancen a cikin Gene na SLCO1B1 na iya shafar magunguna na magunguna, alal misali, ta hanyar sauya ragarwar ƙididdigar da haɓaka Myopathy. Sakamakon haka, Oatop1B1 shine babban abin dubawa a cikin PRARCACOGENOMICS da na musamman magani.

OAT1 (Gudummawar kwayar halittar 1, slc22a6)

Oat1 galibi ana bayyana shi ne a kan membrane na membrane na sel mai zurfi na kasar da shi ke da alhakin koda babban kewayon kwayar halittar jini daga jini. Waɗannan substates sun haɗa da ba kawai metogenous metogenites - kamar kifuyacin nuchulses - amma kuma abubuwan da ke haifar da maganin rigakafi (nSAids), da kuma gubobi na muhalli. Bambance-bambancen a cikin aikin OAT1 ko magana na iya tasiri ga magunguna na magunguna da gudummawa ga magani - Nefd nephrotoxicity. Matsayin Tsakiyar Jirgin ruwa a cikin Ruwa na Girka ya sa ya zama muhimmin alama ga annabta da gudanar da manyan magungunan munanan ƙwayoyi a cikin koda.

Takaitawa da na asibiti

Tare, waɗannan masu jigilar kayayyaki sun haɗa da haɗin kai tsaye, rarraba, rarraba, rarraba metabolism, da excremations (Adme) Matakai na Prouthotherpepy. Haɗin aikinsu ba kawai rinjayi ingancin warkewa da guba na magunguna ba har ma da ɗimbin ayyukan halitta - daga samuwar bile samarwa-daga cikin sadarwa mai gina jiki. A cikin cigaban miyagun ƙwayoyi, fahimtar halaye masu aiki da bambancin ilimin halittar waɗannan masu aikin suna da mahimmanci. Zai taimaka cikin annabta magani - hulda da miyagun ƙwayoyi, keɓaɓɓen tsarin kula da jiyya, da kuma narkar da illa mai illa. Masu bincike da asibitoci suna ci gaba da fatawa da cikakkun hanyoyin aikin sufuri, suna nufin shawo kan ƙalubale da ƙwayoyin cuta - raunin hanawa.

Keywords: ATP - ABC), ABC mai jigilar kaya, MDC II, METP1B1, MEP II, CacO, MD1, BCRP, MDR1, BCRP1, MDP II, METP1B1, MEP II, CacO, MD1, BCRP, MDR1, BCRP, MDR1, BCRP, MDR1, BCRP1, MDP II, SPEP, CacRo, MDR1, BCRP1, MDP II, CacRoaddamar da Shiga, MDR1, BCRP1, MDP II, SPEP II, ICH1, BCRP1, MDP II, INC1, BCRP1, MDP II, SPEPSHORS MEARP, MAD1 M12 Dramstaddamar da Jagora akan Ingantaccen Tsarin Magunguna Nazari, Hek293 Mock, MOCK SLC