Fahimtar rawar da ke jawo s9 a cikin karatuttukan metabolism

A cikin samfuran vitro sun zama masu zaman kansu a cikin guba na zamani da magunguna, musamman lokacin da ɗan gida ke halayyar da ke halayyar motsa jiki kafin ci gaba cikin matakan Vivo. Daya ya karbi kayan aiki wanda aka ɗora a cikin waɗannan karatun shine raunin S9, wani yanki na yanki wanda ya samo asali ne daga homogenates wanda ke riƙe da micryyates duka da enzymes na cytostolal. Waɗannan fage suna ba da damar ingantaccen kimar mahaifa Xenobiotic, ayyukan enzyme, da kuma yiwuwar kunnawa abubuwan gwaji.

DaKashi S9yawanci ana samo shi ne daga kyallen hanta na rodents-beraye da hamsmu sun fi kowa kyau-pre - bi da su da enzyme da enzyme. A sakamakon haifar s9 cakuda ya ƙunshi na enzymes na enzymes kamar yadda Cytachromes kamar yadda Cytachrome p420 oxidases, da kuma lokaci na ii conjugation enzymesfores da sulfotonossferestrasfesfesferesforts. Wannan ya dual - Enzyme Kasancewar yana da mahimmanci yayin da kimanta hanyoyin da ke cikin gida a cikin saitin dakin gwaje-gwaje.

MatsayinHaɓaka hanta S9

Haɓaka hanta S9Shin mafi yawan lokuta ana amfani da shi da yawa, musamman a cikin gwajin kwayoyin halitta kamar su ams assay ko gwajin micronuwlius. Wadannan qura yawanci ana shirya su gaba daya pre - kula da berayen tare da fartawa 1254, phenoblavone. Aroclor 1254, musamman, an yi amfani da musamman don samar da fakilor - Haushi S9, wanda ke ba da tsoratar da ɗaukar hoto na cynochrymes na P450 Isozymes. Waɗannan suna da mahimmanci don ayyukan hanta na enzyme a vivo, samar da haske mai mahimmanci a cikin yadda aka siya da sinadarai ko guba.

Aikace-aikace na AROCLOR - Haushi S9 sun hada da:

• Simulating Mammalian yana aiki a cikin mutagisicar na ƙwayoyin cuta asays

• Binciken Lokaci Na Bincike Na Biita Biotransforforfation na masana'antu na masana'antu

• Tsinkaya miyagun ƙwayoyi na ɗan adam ta hanyar yin nazarin kwatankwacin tsari
  
  
  
  

Yaushe zaka yi amfaniJawo hamster hanta s9

Kodayake berayen sune daidaitattun ma'auni masu dakiku masu yawa,Jawo hamster hanta s9yana ba da bayanin enzyme daban-daban. Wasu mahadi na iya zama metabolized daban dangane da jinsin - takamaiman tsarin tsarin, yin hamstemectchers a cikin beraye ba shi da isarwa. Wannan bambancin faɗaɗa da iyakokin bincike da kuma taimaka rage ragi na ƙarya ko sama - fassarar da jinsin ke haifar da shi.

La'akari da amfani da S9

Lokacin da zaɓar tsarin S9 na S9, masu binciken yakamata suyi la'akari:

• Yanayin fili (Pro - magunguna vs. kai tsaye - aiki fili)

• Nau'in enzymes da ake buƙata (hadawan abu da iskar shaka vs. Conjugation rinjaye)

• Abubuwan da ke gudana (E.G., OECD ko FDA Jagoranci Adheren)

• Yawan daidaito da enzymatic ayyukan S9
  
  
  

Iphayan: Mai aminci goyon baya ga S9 - Dangane da bincike na rayuwa

At Iphayan, mun fahimci hadadden farkon - allting lokaci da gwaji na gudanarwa. Mun bayar da daidaitattun sassan S9, ciki har da haifar da hanta ta hanta s9, da ba hamster hamscer ta haifar da s9, duk kerarre - sanya s9, duk masana'antar da aka sanya s9, duk masana'antu - An gwada kowane tsari don ayyukan enzymatic da Lutu - To - Daidai da Lutu, tabbatar da sakamako mai yawa a duk faɗin bincike na Vitro.

Tare da gwaninta goyon bayan ayyukan harhada magunguna na duniya, muhalli, da cibiyoyin ilimi, Iphayan ya kasance abokin tarayya amintacciyar hanyar samar da abubuwan bincike wanda aka tsara don hadaddun bincike. An samar da kayanmu na S9 daga dabbobin da aka kirkira a hankali a hankali, da kuma kula da cewa kowane shiri ya cika da gwajin gwajin metabolism na zamani.