Mafala Akutoma ndi Maganizo a Sirna Mankhwala (Oligonicleotides)

Chiyambi

Chifukwa cha ukadaulo wapadera waukadaulo, a Sirna mankhwala ayang'ana chidwi pantchito yofufuza mankhwala ndi masiku ano, ndipo ndi imodzi mwazomwe zimathandiza kwambiri ku majini mwachangu kwambiri pakadali pano. Poyerekeza ndi mankhwala ang'onoang'ono a Molecule ndi mankhwala osokoneza bongo, matenda a Sirna amatha kulowererapo kuchokera ku Groncy mankhwala opangira mankhwala. Wachitatu wachitatu wophatikiza mankhwala kuwonjezera pa mankhwala ang'onoang'ono a molekyu ndi mankhwala antiod. 

Komabe, monga gulu latsopano la manyowa, Sirna Mankhwala a Sirna ndi polar, omwe amalipidwa, ndipo amafunikira mitundu yosiyanasiyana ya mankhwala osokoneza bongo ndi mankhwala atsopano a chitukuko cha Sirna.

Kuyambitsa kwa Sirna Mankhwala

Mankhwala a Sirna, omwe amadziwikanso kuti oligonictuotides (mass), amatanthauza mankhwala - okonzeka oligonicleides 18 - 9 nt kutalika. Mankhwala a RNA yaying'ono amaphatikizana ndi RNA yaying'ono (Sirna), antifting origonicnuotide (Aso), Micna), ARNA), ndi antible (Actamer Conjule (Actamer Conjule).

Kafukufuku wapano amayang'ana pamitundu itatu ya Sirna mankhwala: Aso, Sirna ndi Aptamer. Zosiyanasiyana za oligonucleotides zimakhala ndi njira zosiyanasiyana zochitira zinthu zina, ndipo amatenga gawo la zoletsa pamitundu yosiyanasiyana ya Pathogeneis. Aso ndi Sirna achitepo kanthu pamlingo wa arna; Aptamer mwachindunji amalepheretsa ntchito za mapuloteni omwe amakhudzidwa ndi matenda a pathogenesis. Zofananira zawo ndikuti amalowererapo posonyeza majini a chandamale kuti akwaniritse cholinga cha matenda.

Ponseponse, makina apadera a zochita za acid acid ali ndi zabwino zambiri: mankhwala osokoneza bongo, motalika, komanso opambana, komanso chitukuko, chomwe Kuwonedwa ngati m'badwo wachitatu waukadaulo wosankha mankhwala omwe angalimbikitse kusintha kwa malonda opangira mankhwala kutsatira mankhwala ang'onoang'ono a Molecule ndi mankhwala antiod. Makampani ambiri ogwiritsa ntchito mankhwalawa adatulutsa zofufuzira zatsopano komanso kupanga mankhwala a Sirna.

Mkhalidwe wa mankhwala ochepa a acid a acid pamsika

Anavomereza mankhwala ochepera a nuclec acid:

• Antistiente origonootides (Asos): Izi nzotulutsa - DNA kapena ma molekyulu amamangiriridwa kwa a MRNA-RNARDS ORSCES kuti musinthe kumasulira kapena kusintha. Asis Asan Phatikizani:
• Nosunersen (Spinraza): Yovomerezedwa ndi minyewa ya msana.
• Eteplirshirshuen (exonds 51): akufuna surchnne minofu ya dystrophy.
• Oftiven (TeGISTI): Amachitira cholowa cholowa cholowa - amyloidosis.
• RNAS yaying'ono (rnas): kawiri - ma mamolekyu osinthika omwe amalimbikitsa kuwonongeka kwa chandamale.

Kuvomerezedwa kwa Sirna njira monga:

• Patsiran (Omepattro): FDA yoyamba - Stannad Sirna mankhwala, kuyankhula cholowa cholowa - amyloidosis.
• Givosoin (GVLARI): Pachimake pachimake porphyria.
• Lumasiran (Oxlumo): Kufunafuna gawo lalikulu la hyperoxuria 1.
• Aptamers: acid, okhazikika a ma acid omwe amamangidwira mapuloteni apadera.
• Pembiptib (Macugn): Aptamer wovomerezeka wazaka - Kusagwirizana ndi Kufuta kwa Macular.

Mawu osakira: Galnac - Sirna, Sirna kuthawa, matenda a chiwindi lysosomes, ma tritosome, lysosome, lysosomes acid phosphatase