ADME
Pochita kusanthula kwa pharmacokinetics, gawo lofunikira pakuwunika kwamankhwala am'mbuyomu, kutsatsa, kugawa, kagayidwe kazakudya, ndi kutulutsa (ADME) liyenera kufotokozedwa panthawi ya chitukuko cha mankhwala. Mankhwala kagayidwe kachakudya, kapena biotransformation, amatanthauza njira yomwe mankhwala amasinthira kapangidwe kake kuti amwe ndikuchotsa m'thupi. Wogawika mu gawo I & II kagayidwe, biotransformation imapezeka makamaka m'chiwindi, chiwalo chomwe chimakhala ndi michere ya metabolic, komanso ziwalo zina monga matumbo, impso, mapapo, magazi, ndi khungu.
Nkhani yayikulu, yovuta yokhudzana ndi kagayidwe kazakudya ndikuwonjezera zomwe zapezedwa kuti zitsimikizire zolosera za kagayidwe kachakudya ka metabolic mwa anthu, mphamvu ya mankhwala ndi chitetezo. Pazaka zingapo zapitazi, IPHASE yapanga zinthu zambiri zophunzirira kagayidwe kachakudya kuphatikiza kukhazikika kwa metabolic, metabolic phenotype, enzyme inhibition (IC).50). Komanso, IPHASE imaperekanso zothandiza mu- vitro zitsanzo monga hepatocytes oyambirira, chiwindi ndi matumbo microsomes, S9 kagawo kakang'ono, cytosol, CYP recombinases zosonkhanitsidwa ku mitundu yeniyeni m'mayiko osiyanasiyana.