Zolemba zaukadaulo
-
Sulfotransfet (Sult) ya kafukufuku wa DDI, kukhazikika kwa metabolic, ndi enzyme zoletsa
Mawu ofunikira: Mankhwala - kulumikizana ndi mankhwala (DDI), Sulfotransise (STCHYME), enzyme, enzyme, syzyme, enzyme, syzyme, enzyme, syzyme, matenda a anthuWerengani zambiri -
Carboxyreses (CES) mu mankhwala opatsirana a mankhwala: Zomwe zimachitika
Mawu osakira: Mankhwala - Kugwirizana ndi Mankhwala Kugwiritsa Ntchito Mankhwala (DDI), Carboxylestift 1, CarboxyMettrase 2, Carky Carboxymeratianthur, CES Enzymele,Werengani zambiri -
Kugwiritsa ntchito cytochrome p450 (cyp450) ndi UDP - Glucuronosytransit (Ugt) Maphunziro a Milnotype Phenotype ndi enzyme
Mawu Ofunika: Kulumikizana Mabala Kugwiritsa Ntchito Mankhwala (DDI), Cytochrome P450 Enzyme Phunziro la Geyubotili:Werengani zambiri -
A & Aanyama a anthu opanda phokoso a matrix opanda kanthu kwa bionalelytical njira ndi bioanalytical njira yotsimikizika
1 ifase probwinomenpecivition munthu Bile2mliphase Monkey cynomolgus / Macaca Fasalicis Bale, wopereka, macaca fanacolbus / MacacaWerengani zambiri -
Kusanthula kwamiyala yam'madzi (kuwunika kwa CSF) ndi kukhazikika kwa matrix: Kuthetsa mabotolo aluso a matracy mu CNS mankhwala a Bioanalysis
1 Iphase zopindulitsa za ufa wa ufa wa ufa wambiri cybrospinesen / Macaca Fasallaris Strabrospinal madzimadzi amadzimadzi, rosus) conwebWerengani zambiri -
5cy - Resose Phunziro la Ntchito: SRD5A1 & SRD5A2 ya SEBUM REMP SATEMS SAT sayansi
Mawu osakira: Mtundu 1 5ct, lembani 2 5cy - Resopy, 57a1, Ndb5a2, Red5a2, Red5a2, RecterWerengani zambiri -
Kuyambitsa khwangwala S9 Fraction: Kapangidwe ka kachatiabolic fortiction ku Vitro genootoxity ndi mayeso osintha
Mawu osakira: OECD 471, OECD 476, OECD 487, mayeso a masinthidwe, malingaliro a ames, minictis, hprosoma, HGTT / HGPTWerengani zambiri -
Plasma mapuloteni omanga mphamvu: zofanana ndi njira zamagetsi ndi kugwiritsa ntchito ku DDIS
Mawu osakira: Equilibrium Dialysis, Ma prosma protein (PPB), Kumangiriza Pulogalamu ya Plasma (BRPP), Equilibribriver Dialysis DialysWerengani zambiri -
Hepatocytes mu mankhwala metabolism ndi Sirna mankhwala kutumiza: Njira Zowonetsera Mitundu Yosiyanasiyana
Zogulitsa Matchulidwe Oyambira Gawo Loyambira Hepatocytes Iphase Kuyimitsidwa HepaCocytesWerengani zambiri -
Ma Microsomes Okhazikika Pakatikati: Udindo wa gawo ine metabolism ndi gawo ii kagayika
Iphase biosciomes plapsectoctingliction ma mitimaspesiises a anthu mitima ya chiwindi, osakaniza Gender0.5ml, 20mg / Mliphase Monkey (wachinyamataWerengani zambiri -
Spleocytes mu kafukufukuyu: mitundu ndi kudzipatula, kuzizira, zopumira
Mawu osakira: Spulkocytes (spls); Monnomolgus spanocytes; Anyani a Monkey spunocytes; Agalu spanocytes; Canine spullecytes; Rat splenocytes; Mbewa splenocytes; MOSI SPLEOCHCES; Kalulu spullecytes; AwaWerengani zambiri -
Kupita patsogolo ku Bioanalysis: Udindo wa LC - Ms / Ms Mu Ophthalmic Develod ndi Maphunziro am'madzi am'madzi
Ifase probwinomenpecutilizationspecifishase ya anthu am'madzi amtundu wa madzimadzi am'madzi (cynomolbus) am'madzi am'madzi (New Qualand Whink)Werengani zambiri