Matou te fiafia i se tulaga sili ona lelei i totonu o matou faʻamoemoega mo a matou oloa sili ona maualuga, tau faʻatauva ma le auaunaga lelei mo le isumu-cd14-,Maile PBMC, PBMC pusa vavae, Beagle Canine PBMC, faiga fa'ale-aganu'u. Ina ia faʻaleleia atili le faʻalauteleina o maketi, matou te valaʻauina ma le faʻamaoni tagata taʻitoʻatasi ma tagata e tuʻuina atu e faʻapipiʻi e avea o se sui sooupu. O a matou oloa e lauiloa lautele ma faʻatuatuaina e tagata faʻaoga ma e mafai ona faʻafeiloaʻi faʻaauau le atinaʻeina o manaʻoga tau tamaoaiga ma agafesootai. Matou te faʻafeiloaʻi tagata fou ma tagata tuai mai soʻo se ituaiga olaga e faʻafesoʻotaʻi i matou mo mafutaga pisinisi i le lumanaʻi ma ausia le manuia faʻatasi!fa'aosoina le SD Rat Liver S9, fatuga'o S9 vaega ninii pusa, fualaau o le plasma protein pusa fusifusia, Hepatocyte Medium kit.
Folasaga: Taua o Sprague Dawley Rats i Suʻesuʻega Ua avea rats Sprague Dawley ma vaega taua o suʻesuʻega faʻasaienisi ona o latou uiga faʻapitoa ma agavaʻa i faʻasalalauga eseese.
O le tu'u'ese'eseina o le toto Mononuclear Cells (PBMC) ose auala taua i su'esu'ega fa'alesoifua maloloina ma fa'aoga falema'i. O nei sela e aofia ai lymphocytes (faataitaiga, sela T, sela B, sela NK) a
Folasaga i le Liver MicrosomesMicrosomes o ni fasi vesicular laiti e maua mai le endoplasmic reticulum ma e maua i totonu o sela ate (hepatocytes). Latou te faia se sao taua i meaola eseese
Sa matou fiafia e auai i lenei tausaga Saina Biopharmaceutical Association - Greater Philadelphia (CBA-GP) Konafesi Faaletausaga, o se mea na tupu na tuufaatasia ai se nuu mataʻina o sch
O le in vivo alkaline comet assay ua faʻateleina le faʻaaogaina i le suʻesuʻeina o le genotoxicity o mea faʻapipiʻi. ICH S2(R1) ua aofia ai le liver comet assay o le 2nd in vivo test mo tissues/endpoints; a
I le tulaga lautele o su'esu'ega fa'alesoifua maloloina ma vaila'au, ua fa'alauiloa e le IPHASE se fa'asologa o pusa biomicrosomes maualuga-fa'atinoga, e aofia ai pusa microsomes ate, pusa microsomes intestinal ma micros intestinal.
Matou te lagona le faigofie ona galulue faʻatasi ma lenei kamupani, o le tagata faʻatau oloa e matua nafa ma, faʻafetai. O le a sili atu le - felagolagomai loloto.
Pule e va'ava'ai, latou te maua le manatu o le "fa'amanuiaga fa'atasi, fa'aauau pea le fa'aleleia ma le fa'afouina", matou te maua se talanoaga manaia ma le Felagolagomai.
O uiga galulue fa'asoa e matua lelei lava, feagai ma fa'afitauli eseese, e naunau i taimi uma e galulue fa'atasi ma i tatou, ia i tatou o le Atua moni.
O lenei atinaʻe i totonu o le alamanuia e malosi ma faʻatauva, agai i luma ma taimi ma atinaʻe gafataulimaina, matou te matua fiafia lava e maua se avanoa e galulue faʻatasi ai!
Faʻatasi ai ma se uiga lelei o le "manatu i le maketi, vaʻavaʻai i tu ma aga, faʻasaienisi", o loʻo galue malosi le kamupani e fai suʻesuʻega ma atinaʻe. Fa'amoemoe e iai so tatou mafutaga fa'apisinisi i le lumana'i ma ausia le manuia fa'atasi.
O loʻo i ai i le aufaigaluega fale gaosi oloa le poto masani faʻapisinisi ma le poto masani faʻagaioiga, matou te aʻoaʻoina le tele o mea i le galulue faʻatasi ma i latou, matou te matua faʻafetai lava e mafai ona matou faʻaalia se kamupani lelei o loʻo i ai ni tagata faigaluega lelei.