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What Is Induced S9?
Introduction to Induced S9 Induced S9 is a liver-derived enzyme fraction commonly used in toxicology and biochemical research. It is prepared by inducing liver enzymes in animals, such as rats or hamsRead more -
What Are N-Nitrosamines?
N-Nitrosamines N-nitrosamines, represented by the structural formula R1(R2)N-N=O, are formed through various mechanisms, including reactions between secondary amines and nitrous acid, tertiary aminesRead more -
N-Nitrosamines: An Enhanced Ames Test with Hamster liver S9
Keywords: N-Nitrosamines, NDSRIs, OECD 471, Enhanced Ames test, Hamster liver S9, Cytochrome P450 enzymes, Mutation Test IPHASE Products Product Name Specification IPHASEGolden Syrian HamstRead more -
Plateable Hepatocytes vs. Suspension Hepatocytes: Key Differences and Applications in Drug Testing
I. Introduction In drug development and toxicology research, hepatocytes play a crucial role in evaluating the metabolism and safety of new drug candidates. Among them, plateable hepatocytesand suspenRead more -
CGT Innovative Therapy - Lentivirus-packaging CAR-T immune cells
CGT Innovative Therapy - Lentivirus-packagingCAR-T immune cells Immune cell therapy is an innovative cancer treatment that enhances the body's immune system to target and eliminate cancer cells. Key fRead more -
Human Liver Microsomes in Drug Development: How They Impact Pharmacokinetics
1. Introduction: Understanding Human Liver Microsomes In modern drug development, predicting how a drug is metabolized in the human body is crucial for ensuring both efficacy and safety. Human liver mRead more -
Primary Hepatocytes: A Crucial Tool for Advancing Non-Clinical In Vitro Drug Research
Primary Hepatocytes: A Crucial Tool for Advancing Non-Clinical In Vitro Drug Research Liver, as the primary organ for drug exposure, plays a crucial role in drug metabolism and toxicity processes. PriRead more -
Microsomes: The Preferred In Vitro Metabolic Model for Nonclinical Drug Research
Microsomes: The Preferred In Vitro Metabolic Model for Nonclinical Drug Research Microsomes: Definition and Functions In most cases, microsomes refer to spherical, vesicular membrane structures approxRead more -
Lysosomes (Tritosomes):A predictive in vitro test system for catabolism or lysosomal stability studies
IPHASE Products Item No. Product Name Specification 0151A1.03 IPHASE Human Liver Lysosomes,Mixed Gender 250μL,2mg/mL 0151B1.01 IPHASE Monkey(Cynomolgus) Liver Lysosomes,MaleRead more -
IPHASE Solutions for siRNA Drug In Vitro Metabolism Research
IPHASE Solutions for siRNA Drug In Vitro Metabolism Research Nucleic acid drugs, due to their unique technological characteristics, have become the focus of new drug development in recent years. NuclRead more -
What is the comet test?
Introduction to the Comet Test The comet test, also known as the comet assay, is a sensitive and versatile technique used to measure DNA damage in individual cells. Originally developed to study variations in DNA damage and repair within populations of maRead more -
What are primary hepatocytes?
Introduction to Primary Hepatocytes Primary hepatocytes are the cornerstone of liver research and are pivotal in understanding liver function, drug metabolism, and liver diseases. As the primary cellRead more