Gabatarwa zuwaHanta micosomes
Microsomes sune ƙananan guntunsu masu ɓarna waɗanda aka samu daga wasan kwaikwayo na entoplasmic kuma ana samun su cikin sel na hanta (hepatocytes). Suna taka muhimmiyar rawa a cikin matakan biochathical daban-daban, mafi yawa a cikin metabolism magani da detoxification. Fahimtar tsarin, aiki, da mahimmancin Microsomes na hanta suna da mahimmanci don godiya ga magungunansu, guba, da lafiyar hanta gaba ɗaya.
Tsari da samuwar microsomes
● Asalin daga Entoplasmic na Beticulum
An kafa Micronomes a lokacin homogenazation da bambancin ƙwayoyin hanta, inda entoplasic na gabanta ya rushe cikin ƙananan vesicles. Wannan tsari yana ba da damar ware waɗannan ƙananan ƙananan abubuwan, waɗanda suke da wadata a cikin enzymes da mahimmanci don ayyukan rayuwa daban-daban.
● Composition da ilimin jiki
Halin hanta yana kunshi farkon membrane - Kasancewar enzymes, lipids da sunadarai. Tsarin nasu yana ba su damar sauƙaƙe halayen ɓoyayyen tarihin biochemical da yawa, gami da waɗancan Catalynzed da tsarin canzarnuwa na Cynathe. Halayen halittun na microsomes suna da mahimmanci wajen tantance damar aikinsu na aiki a hanyoyin rayuwa.
Microsomes da metabolism metabolism
● rawa a cikin Detexfication
Hanyar hanta Microsomes suna da alaƙa da ikon jiki don kawar da mahadi daban-daban, gami da kwayoyi da kuma gubobi muhalli. Wannan tsari detovification ya ƙunshi canza abubuwa masu lipphilic zuwa cikin ƙarin ruwa - siffofin slums waɗanda za a iya magance su cikin jiki.
● Syntachrome p450 tsarin enzyme
Ofaya daga cikin abubuwan da suka fi muhimmanci a cikin hanta Microschrome shine Cytochrrome P450 (Cyp) tsarin enzyme. Wadannan enzymes suna da alhakin da ke da metabolism na oxdative na kewayon subsitrates, gami da magunguna, saboda haka yana wasa muhimmiyar rawa a cikin metabolism magunguna. Ayyukan waɗannan enzymes na iya rinjayi ingancin magunguna da guba na magunguna.
Enzymes microommes da ayyukansu
● Nau'in enzymes yanzu
Haɗe Micliys suna ɗauke da nau'ikan enzymes da yawa, ciki har da oxidases, Redawa, da hydrolaases. Kowane nau'in enzyme ya kware musamman wajen sauƙaƙe takamaiman halayen bitical, yana ba da gudummawa ga ingancin hanta na hanta.
● takamaiman halayen catalalzed
Enzymes a cikin hanta Microomes Catalyze daban-daban halayen, kamar oxidation, raguwa, hydrolalysis, da kuma gudanarwa. Waɗannan halayen suna da mahimmanci ga Biotransption na engogenous da abubuwan da suka dace na mahadi, tabbatar da ingantaccen zubar da metabolic.
Matsayi a cikin Xenobiotic metabolism
Rage abubuwa na kasashen waje
Microsomes suna da mahimmanci a cikin metabolizing Xenobiotics-abubuwan da ke shiga jiki, kamar magunguna, carcinogens, da kuma gurɓasa. Ta hanyar jerin halayen enzymatic, Microsomes ke sauya waɗannan abubuwa masu cutarwa zuwa ƙarancin mai guba kuma mafi sauƙin cirewa.
● Muhimmancin a cikin ilimin likitanci da guba
Ikon hanta Microsomerize Xenobotics yana da mahimman abubuwan magunguna da guba. GASKIYA Aikin Microomal yana taimakawa hasashen hulɗar miyagun ƙwayoyi, masu yiwuwa sakamako masu illa, da kuma bambance-bambancen mutum a cikin metabolism magunguna, miyagun ƙwayoyi da dabarun warkewa.
Microsomes a cikin Lipid Metabolism
● synthesis na lipids
Halin da Microsomes suna wasa muhimmiyar rawa a cikin lipid metabolism, ciki har da tsarin kira na phospholipids da triglycerippides. Wadannan lipids muhimmin abubuwan da membranes na sel kuma suna aiki a matsayin kwayoyin ajiya na makamashi, nuna mahimmancin Microsomes a cikin kiyaye amincin salula.
● rawa a cikin cholesterol da steroid metabolism
Microsomes suna da hannu a cikin biosynthesis da tsari na cholesterol da steroid kwayoyin. Enzymes a tsakanin micolomes sauƙaƙe canjin cholesterol cikin bile acid da steroid eretones, da suka kasance mai mahimmanci ga da lafiyar ilimin jiki, gami da narkewar lafiyar jiki.
Tsari na aikin Microsomal
● Gaskiya tasiri ayyuka masu ma'ana
Abubuwa da yawa na iya yin tasiri kan ayyukan enzymes na micrymes, ciki har da bambancin kwayoyin halitta, Age, Jima'i, da cocin. Bugu da ƙari, dalilai na waje kamar abinci, bayyanar muhalli, da kuma kasancewar wasu magunguna na iya daidaita aikin enzyme, yana shafar aikin hanta da metabolism magani.
Tasiri na Abincin da Muhalli
Abubuwan da aka gyara na Abincin da kuma abubuwan muhalli suna taka muhimmiyar rawa wajen gudanar da aikin Microsomal. Misali, wasu abinci na iya haifar da shi ko hana ayyukan cynochromes P450 enzymes, suna haifar da bambance-bambancen a cikin metabolism magani da tasiri. Motsi na muhalli na iya tasiri aikin Microsomal, wanda ya shafi iyawar hanta don kawar da abubuwa masu cutarwa.
Canje-canje na cututtukan cuta a cikin microsomes
Tasri da cututtukan hanta
Cututtukan hanta kamar hepatitis, Cirrhosis, da cutar mai hanta na iya haifar da canji a cikin ayyukan enzyme da tsari. Waɗannan canje-canjen suna iya lalata ikon hanta don yin maganin magunguna da sauran abubuwa, suna ba da gudummawa ga ci gaba na cututtukan hanta da haɓaka rikice-rikice.
● canje-canje saboda shan giya ko cinyewa
Amfani da barasa da shan magunguna na iya haifar da mahimman canje-canje a cikin microomes hanta, gami da gabatarwar enzyme ko hanawa. Wadannan gyare-gyare na iya shafar damar da hanta ya kwashe abubuwa na kwantar da hankali, yiwuwar haifar da tuki da guba da lalacewar hanta.
Microomes a cikin bincike da bincike
● Yi amfani da nazarin hulɗa na miyagun ƙwayoyi
Halita Michyoyin MicrComes suna da amfani sosai a cikin binciken da ke tattare da bincike na cigaba da kuma hango hanyoyin da ke tattare da makamantan rayuwa. Masu bincike suna amfani da hanjin hanji don kimanta yiwuwar hulɗar miyagun ƙwayoyi, ƙayyade mahimmancin mahadi don haɓaka ci gaban kwayoyi.
● Aikace-aikace a cikin ilimin asibiti
A cikin asibitoci na asibiti, hanta hanta suna aiki azaman kayan aiki mai mahimmanci don tantance aikin hanta da gano rikicewar metabolism. Cutarwar ta hanta tana iya taimakawa wajen gano karancin enzyme ko rashin kunya, tana jagorantar kayan aikin warkarwa da kuma kula da ingantaccen magani.
Hanyoyi na gaba da sababbin abubuwa
● Ci gaba a Binciken Microsomal
Bincike mai gudana a fagen ilimin Microsomal ya ci gaba da agaji sabon fahimta cikin aikin da kuma tsari na Microsomes na Versions. Ci gaba a cikin Genomics, Protomolomics, da Metabolomics na haɓaka fahimtarmu game da yanayin enzymes da cuta, su tsara hanyar da labari mai ƙarfi na warkewa.
Fasaha na Emering da hanyoyin
Ingantaccen fasahar da hanyoyin ana inganta su don inganta binciken na Micromes na cututtukan microomes. High - Shawarwari, dabarun ɗaukar hoto, da kayan aikin halittu masu zurfi suna inganta mafi daidai kuma ana sauƙaƙe gano sabbin magunguna da dabarun warkewa.
Game da iphase
Hedkwen a Arewa, Pennsylvania, Iphayan BiosCiesss shine ƙwararrun, sabon labari, da haɓaka masana'antu da ke haɓaka bincike, ci gaba, samarwa, tallace-tallace, tallace-tallace, tallace-tallace, tallace-tallace, tallace-tallace, tallace-tallace, da sabis na fasaha na reacology reagents. Levorging mai mahimmanci da so don binciken kimiyya, ƙungiyar kimiyya ta ƙwararrun masana ta ninka ta 50 da ke gaba da masu bincike don cimma burin su na kimiyya. Finawa da R & D kyakkyawan na "repates reagents," in ji na gaba, da rarraba abokan shakatawa, da abokan tallace-tallace na kasashen gabashin Asiya fiye da murabba'in Asiya 12,000.
Lokaci: 2024 - 08 - 09 17:12:10