Ke noi aku nei i ke kiʻi Cytochrome P450

Nā hua'ōlelo nui: lāʻau lapaʻau - Kaʻauʻauʻau lāʻau (ddi), cytochrome p450 Cyp3Sa4 / 5, Cyp2A6, Cyp4A1, UgT1A7, UGT1B15, UGT2B7, UgT2B7, Ugt2b17, Ugt2b17

• Huaʻai iphese

Kahakaha: Hoʻohana pinepineʻia nā enzymes cyp meʻO ka'ōnaehana hoʻonohonoho inoaʻo Nadph/ NadphaPbs
Hoʻohana pinepineʻia nā UGT enzymes'Ōnaehana incupubation ugt incubationa pbs.

Ke pāʻani neiʻo Metabolisism i kahi hana koʻikoʻi ma ka hopena o nā lāʻau lapaʻau, e pili ana i ko lākou hanaʻana i ke kino a me ka hopena hopena. ʻO kēia mau mea nui loa i ka manawa, akā hiki paha i nā mea hana i nā organs extrahepatic. Ua hōʻike houʻia nā noiʻi houʻana i ke ola a me ka hana nui o ka lāʻau lapaʻau metabolizingCytochrome p450 enzyme (cyp)aUdp - glucuronosyltrasrase (Ugt) Aia nō hoʻi nā mea komo i nā mea i loko o ka lāʻau lapaʻau lāʻau lapaʻau ma loko o ka'ōnaehana o ke kikowaena waena (cns).

• Cytochrome p450 (cyp)

ʻO Cytochroome P450 ka mea i hoʻopaʻaʻia i nā metabolism Hoʻokomoʻia nā subfyps i ke kiʻi cyp3 (50% mau lāʻau lapaʻau lāʻau lapaʻau) a me cyp2d6 (20% lāʻau lapaʻau lāʻau lapaʻau). Hoʻololiʻo Cyp i nā lāʻau lapaʻau lipophilic i loko o nā metabolites polar, hoʻolaha i ka excretion.

ʻO nā hepatocytes mua hepatocytes i waho o nā hepatocytes mai ke kanaka a iʻole holoholona holoholona, ​​a lilo i ka hana hoʻohālike no ka mālamaʻana i ka lāʻau lapaʻau ʻO keʻano hoʻohālike o ka hepatokes mua ka mea loiloi nui loa i mākaukau nui no CHAP enuzyme i ka hana, Academika. E like me kahi'ōnaehana cellular,ʻo ia keʻano o nā mea hou aku i nā mea hou aku, a me nā mea hoʻonaninani, e like me ka lāʻau lapaʻau

• Udp - glucuronosyltrasrase (Ugt)

Udp -ʻO GlucuronyysfarSeltransFensferesʻo ia kahi papa muaʻo ⅱ everzyme e hoʻohana ana i ka ake glucuronic a me ka nui o nā mea i hoʻopaʻaʻia e nā cheding Ua hoʻokaʻawaleʻiaʻo Ugt Ugt a hōʻikeʻia i nāʻili e like me ke ola, nā'ōpū liʻiliʻi, nā'ōpū, a me nā māmā. ʻO ka mea ola ka mea nui i ke kino o ke kanaka e hoʻopili ana i nā hua lāʻau glucuronic aclucing, aʻo ka hapa nui o nā subtypes ugt. UGT1A7, UGT1A8, UGT1A10, a me ka UGT2A1 e pili ana i ka hopena extrahepatic

• Nā noi nui i ka hoʻomohala lāʻau

Ma keʻano hoʻohālike Scout Screen Me ka hoʻohanaʻana i nā cell i hoʻoponoponoʻia e wānana i nāʻokoʻa a metablic.

Lāʻau lapaʻau - Kaʻauʻau lāʻau (ddi)Study E hana i nā hoʻokolohua Igt Ugt e loiloi i ka hopena o nā lāʻau lapaʻau ma Ugt hana. Ke nānā nei i ka hopena induction o nā lāʻau lapaʻau ma cyp / ugt ma o nā loiloi hepatocytes mua.

ʻO ka hoʻomohalaʻana i nāʻano loiloi loiloi:ʻO ke aʻoʻana o Cyp a me Ugt enzymes e pāʻani ana i kahi hana koʻikoʻi a me ka hōʻoiaʻana no ka lāʻau lapaʻau. E hoʻohana i nā Matricical Biological i loaʻa i nā metablites cyp / ugt metabolites (e like me ka baile a me ka plasma.

ʻO Genetic Polymorpormism noiʻi: UGT1A1 a me nāʻano'ē aʻe e hoʻopili ai i nā genentme e pili ana i nā genes he nui. Me ka hoʻolālāʻana o nā Parismacogenomimics, ua loaʻa ka pourmorphisism e pili ana i nā pae metabolphism e pili ana i nā maʻi metaboless a me nā mea'ē aʻe.

Aʻo ma nāʻano likeʻole: hoʻohālikelike i nāʻokoʻa ma keʻano he nui e like me keʻano o keʻano o ka mea kūʻai aku.

• Enzyme i ka

Cyp enzyme i hoʻohuiʻiaenzyme i kaE pili ana i ka phenomenon kahi e hiki ai i kekahi mau mea hoʻohui i nā hana o kekahi mau lāʻau lapaʻau, a hoʻonui i ka hoʻohuiʻana i kahi mau lāʻau lapaʻau i hoʻohanaʻia i ka hoʻohuiʻana i ka lāʻau lapaʻau E like me nā mea hana likeʻole o ka paleʻana, ka hopena o ka lāʻau lapaʻau o nā lāʻau lapaʻau ma cyp450. ʻO ka hanaʻana i ka manawa hilinaʻi,ʻikeʻiaʻo ia e like me ka hanaʻoleʻole, ka mea maʻamau e pili ana i keʻano o ka lāʻau lapaʻau ma waena o kahi paʻaʻana o kahi mea hoʻopiʻi. ʻO ka hopena hoʻohālikelike o ka Ihibitor ma ka enzymeʻaʻole e nalowale koke ma hope o ka hemoʻana o ka Ihibibitor.

• Cyp450 envyme metabolic phewypep

I kēia manawa, heʻekolu mau kumu nui no ka hoʻomaopopoʻana i ka metabolic o ka cyp450: koho i keʻano o ka cyp450. Hiki ke hoʻokaʻawaleʻia keʻano hoʻohālikelike koho koho i loko o keʻano o keʻano o keʻano o keʻano a me keʻano o keʻano o keʻano. E pili ana i ke anaʻana i ka hana metabolic o nā microsome o nā microsope o keʻano o ka cyp450 ENTYME METABO MEROTYPE. I waena o lākou, ua hoʻohana nuiʻia keʻano hana loiloi ma muli o kāna hana maʻalahi a me ke kumukūʻai haʻahaʻa.

• Hopena

Cyp enzymes a me Ugt enzymes, e like me nā'ōnaehana o nā lāʻau lapaʻau Subtypes e like me cyp3a4 a me cyp2d6, me nā enzymes e like me ugt1a1 a me Ugt2b7 ʻO kā lākou hana likeʻole (e like me ka pymormphimism a me nā mea kiko'ī) hiki ke loiloiʻia i nā hiʻohiʻona hepatocytes a me nāʻenehana nui.

Kamaʻilio

Zhang, M., rotschiäfer, v., & cm de lange, e. (2024). ʻO ka hopena kūpono o ke cyp a me Ugt lāʻau lapaʻau - Metabolizing enzymes ma ka hoʻolahaʻana o ka lāʻau lapaʻau. Nā loiloi lāʻau lapaʻau lāʻau, 56(1), 1 - 30.

Ghosal, A., ROMANTAN, R., Kronnini, B. S. H. C. B. B. (2005). Cytochrome p450 (cyp) a me udp - glucuronyltransfenas I Ka holomua ma ka lāʻau lapaʻau a me ka loiloi biometical (Vol. 6, pp. 295 - 336). Mea'ē aʻe.