Nā Nūhou maikaʻi: Ua huiʻo Iphies i nā lima me ke kulanui o Pennsylvania e hoʻomohala i nā antibodies hou!

ʻO kēia manawa,ʻo Iphise, i ka huiʻana me ke kulaʻo Peelman ma ke kulaʻo Anti - monoclonal antioney hz - 1127 a ho'āʻoʻia i konaʻano paʻa, kiko'ī a me ka hiki ke paleʻia i ka tslp.
ʻO kāu stromhhoomiictinitin lymmphopopohitin (Tslp) he lālā o kaIl - 2 cytokineʻO kaʻohana, a me ka dysgulation o ka tslp - tslp receptor (tslpr) e pili ana i ka uluʻana o nā maʻi maʻi. No laila,ʻo ka hoʻopaʻaʻana o ke kaula kiko'ī e hoʻohana ana i nā antibodies he hoʻolālā kūpono no ka mālamaʻana i nā maʻi maʻi a me nā pale. Ua loaʻa i ka FDA i kēia manawa ke texulumab, kahi anti line - tslp monoclosal
Ua hoʻomohalaʻo Iphase no ka manawa mua i kēia aʻoʻana i kahi Anti kanaka hou. Ua hoʻohālikelikeʻia me Tezepelumab, i hoʻopaʻaʻia ka Epitop e pili ana i Tslp e nā mea likeʻole e hoʻopaʻaʻia ma waena o Tslp a me TSLPR. Hz - 1127 Ua hōʻikeʻia hoʻi nā hopena maikaʻi loa iā Tezepelumab ma TSLP -ʻO CLCL02 he mau maʻi maʻi a me CLCLD2. 1127 Mei.
Ua pili kaʻenehanaʻo Antibody i kēia noiʻi a me nā polokalamu loiloi e pili ana a me nā mea hana i hoʻohanaʻia e nā hoʻokolohua ma IPase.


Kakauʻana o Fig.1 i ka mononclosal anti wikiō hz - 1127

ʻO Fig .2Pbmcs

ʻO ka hōʻike SCEC.3 Schematic e hōʻike ana i ka hopena o ka inshigortor o ka hz - 1127 a me ka tezepeluluba ma luna o Tslp hōʻailona