ADC Arụmọrụ DS8201A - DXFG - DXD Sistem

Ndubata

Antabod - ogwu na-eme ka ihe ndị na-agbanwe agbanwe nke usoro ọgwụgwọ ọrịa cancer ezubere iche na-ejikọ nkọwa nke nje monoconal nke nwere ọgwụ. Site na ngbanwe a, na-eleda Antody, a na-eleghara anya ma ọ bụ na-enweghị ike, adcs na-enye ihe dị irè na-ewepụ mkpụrụ ndụ cancer mgbe ị na-ebelata anụ ahụ.

Usoro nke adcs na ọrụ nke Cathopsin B

Ezubere adcs ka ọ napụta ndị ọrụ Cytotoxic na cell cell site na itinye aka na teamo ụfọdụ - Antigens jikọtara. Ozugbo a ga-ekenye adc site na Reneptor - a na-ahụ maka mkpọchi na ịzụ ahịa na ndị Lọmome, ebe a na-ahapụ ọgwụ Cytotoxic. Otu n'ime enzymes dị mkpa metụtara na mwepụta a bụ Camepsin B, CySosomal Cysteine ​​na-ezu ike. CatEpsin B na-arụ ọrụ dị oke mkpa na peptide - sitere na ndị na-ahụ maka njikọ na Adcs, na-agba mbọ na-egbu egbu mkpụrụ ndụ na-enweghị atụ.

DS8201A: a na-esote - Ọgbọ ADC

DS8201A A makwaara dị ka [GAD - trastguzumab deruxtab deruxtcan - NXKI] O nwere tratuzumbab - Antody jikọtara ọnụ na Potient Topomomerase m na-arụ ọrụ na-arụ ọrụ site na njigide. ADC a nwere ọgwụ dị elu - ka - Antod ruru (DAR) ma e jiri ya tụnyere na mbụ ha2 - ADCS, na-eduga na mgbochi na-eme ka anti@ kansa. DS8201A na-amakwa maka mmetụta ya, na-enye ohere ịkwụ ụgwọ na-agbasa ma na-egbu mkpụrụ ndụ cancer na-arịa ọrịa kansa n'agbanyeghị okwu ya.

GGFG - DXD: Onye na-ahụ maka ihe ọhụrụ na DS8201A

Otu ihe dị mkpa na ihe ịga nke ọma DS8201 bụ nke pụrụ iche nke Concaenable Njikọ, GGFG - DXD. Conlycine a nwere Glycine - Glycine - Gyfline (Gyfline (nke dị ike na-atọgbọ nke ọma, nke a na-ahụkarị nke ọma, na-arụ ọrụ nke ọma. A na-emepụta Njikọ GGFG iji meziwanye nkwụsi ike mgbe ị na-ejide ntọhapụ ngwa ngwa ma na-achịkwa ọgwụ cytotoxic.

Mmechi

ADCS dịka DS8201A na-anọchi anya usoro ọgwụgwọ ọrịa kansa, na-enye nnyefe nke ndị ọrụ nwere ike nwere ike belata na-emebi emebi. Ọrụ nke Cathopsin B na Njikọ Njikọ, usoro GGFG, usoro njikọ DXD, yana arụmọrụ dị elu nke DS8201A na-egosi na ọganiti na teknụzụ Ads. Dika mmepe Adc na-aga n'ihu, na-enwekwu njigide nke ndị na-ahụ maka njikọ, na-akwụ ụgwọ, na mgbochi ndị na-ebute ga-eme ka ọ bụrụ usoro ọgwụgwọ ọrịa kansa dị irè na nkeonwe.

Keywords: Nchịkọta Njikọ, Imeju Lysity, Lyssimal Catabilism, Catpsin B, DS8201A, GGFG - DXD