Okwu Mmalite na echiche nke Salna ọgwụ (Oligonucleotides)

Ndabere

Site na njirimara ya pụrụ iche, ọgwụ Sirna abụrụla uche nke nlebara anya nke nyocha ọgwụ nje na mmepe ọhụrụ n'afọ ndị na-adịbeghị anya, ma bụrụ otu n'ime usoro ọgwụgwọ na-etolite ngwa ngwa. Tụnyere obere ọgwụ na ọgwụ mgbochi, ọgwụ Sirna nwere ike itinye aka na ya, ọ bụghị ihe ịga nke ọma, na-aga n'ihu na-emegharị ọgwụgwụ na ọgwụ mgbochi na-aga n'ihu . Nke atọ nke ọgbara ọhụrụ na mgbakwunye na obere nwa agbọghọ ọgwụ na ọgwụ ọgwụ ọgwụ. 

Agbanyeghị, dị ka ụmụ irighiri ọgwụ ọhụrụ, ọgwụ Salna bụ polar, na-akwụ ụgwọ, ma si otú a nwee ihe ịma aka na kemịkalụ nke ọgwụ sirna.

Okwu Mmalite nke Ọgwụ Sina

Ọgwụ Sirna, nke a makwaara dị ka Oligonucleotides (ONS), na-ezo aka na ọgwụ - na-ezo aka ọdịdị na-abụkarị 18 - 30 nt n'ogologo. Obere ọgwụ RNA gụnyere obere ihe na-egbochi RNA (Oligonicleotide (APNA), APNA), Aptamer, na Anna na-arụ ọrụ - Oligonucleic Conjugates (AOC).

Nchọpụta dị ugbu a na-elekwasị anya n'ụdị ọgwụ Syna: ASO, SINNA na aptaamer. Oligonucleides dị iche iche nwere usoro dị iche iche, ha na-arụ ọrụ nke igbochi ọrụ na ọkwa dị iche iche nke nje. ASO na Sirna na-eme na ọkwa nke MRA; Aptamer na-egbochi ọrụ proteins na-etinye na patsogenesis. Isi ihe ha na-ekwu bụ na ha na-etinye ihe nke mkpụrụ ndụ ihe nketa iji mezuo ebumnuche ọrịa.

Onwe ihe niile, usoro pụrụ iche nke ihe na-eme ka ọgwụ ọgwụ nucleic nwere ọtụtụ uru na ọgwụ mgbochi, ma e jiri ya tụnyere ọnọdụ ọgwụ, na-arụ ọrụ, na nsonaazụ na-adịgide adịgide nke nyocha na mmepe, nke bụ A na-ewere dị ka ọgbọ nke atọ nke ọgwụ nrụpụta nke ga-akwalite mgbanwe nke ụlọ ọrụ ọgwụ na-eso obere ọgwụ moleudy. More ma ndị ọzọ na ụlọ ọrụ ọgwụ tinyegoro na nyocha ọhụụ na mmepe nke ọgwụ Sina.

Ọnọdụ nke obere ọgwụ nucleic acid na ahịa

Obere ọgwụ acid na-atọ ụtọ:

• Astonucle Oligonutuotides (Assion): Asses a - thandes DNA ma ọ bụ RNA ma ọ bụ RNA na-ejikọ ọnụ ọgụgụ MRNA iji gbanwee ngọngọ. ASOS ASOS gụnyere:
• Nusinen (Spinraza): kwadoro maka accular accular.
• Eteplirsen (exondys 51): Ebumnuche Duchenne mystrophy.
• Inotteren (Tegsedi): na-emeso transythyretin - amyloyosis medloidosis.
• Obere ihe na-egbochi Rnas (Simas): Ugboro abụọ - tbọn RNA na-akwalite nkọ nke MRA nke ọma.

A kwadoro ọgwụgwọ pọla gụnyere:

• Patisiran (OnPATTO): FDA nke mbụ - A na-akwado Salna ọgwụ, na-agwa okwu Transyhetin - amyloyosis.
• Nye givosiran (giflaarari): maka nnukwu pophic pophphyria.
• Lumasiran (Oxlumo): Asses Pripoxaluria Prish Pripoxaluria 1.
• Aptamers: Acid acid acid nke jikọtara protein a kapịrị ọnụ.
• Pegapten (Macgen): Aptamer kwadoro ka ọ dị afọ - decgeneration.

Keywords: Galnac - Syna, nnyefe Sirna, SpatoSomes, Hough He Catabolism, Lystomal Cabilis, lysosomal acid phosphatal