Mafala Akutoma Nawo A B ndi Kufunika Kwawo
Mu tsamba lokhala ndi vuto la chitetezo chamunthu, ma cell amatenga gawo lofunikira. Monga mtundu wa khungu loyera, ma 2 ma cell omwe ali ofanana ndi mayankho olimbitsa thupi, makamaka amayambitsa ma antibodies motsutsana ndi tizilombo toyambitsa matenda. Kutha kwawo kwapadera kuzindikira antigans ndi momwe amathandizira kukumbukira mosamala kumawapangitsa kuti aziphunzira kafukufukuyu. Kuzindikira momwe mungasule bwino ma cell ndikofunikira kuti tiwonjezere chidziwitso chathu m'malo monga katemera, kuloza matenda a Autoimmune, ndi khansa ya Andnurotherapy.
Kumvetsetsa B Cell Cell: Mitundu Yofunika
B Cell Cell Idolation ndi njira yofunika kwambiri pakufufuza zinthu mosathawika komwe kumaphatikizapo kulekanitsa ma B) kuchokera ku maselo osakanizika. Cholinga chake ndikupeza ma cell as cell omwe amagwiritsidwa ntchito zosiyanasiyana, kuphatikizapo madandaulo azogwira, geneti mawu, ndi zochitika zochimwa. Njira yokhayokha imadalira olemba apadera a ma b maselo, omwe amawalola kuti asiyane ndi mitundu ina yam'maselo. Monga "B Cell Isolation Kit"Zimakhala Zofunika Kwambiri Monga Zoyeserera Zofunikira Njira Zodalirika ndi Zida zothandizira kuyeserera kwawo. Kumvetsetsa kwa malingaliro ofunikira kuti aliyense azichita maphunziro anthawi yayitali kapena akatswiri azachipatala omwe amagwiritsa ntchito ma beloni.
Kukonzekera zitsanzo za B Cell Cell Cell
Kugwiritsa ntchito kwa B kwa cell kumayamba ndi kukonzekera kosankha kwa zitsanzo. Njirayi imayamba ndi kusonkhanitsa magazi kapena minofu, yomwe imakonzedwa kuti ipeze mmodzi - Kuyimitsidwa kwa cell. Kusamalira Moyenera ndi Kusunga kwa zitsanzo ndizofunikira kuti musunge pakati pa maselo ndi kukhulupirika, zomwe zimapangitsa kuti zinthu ziziwayendera bwino kwambiri. Kuonetsetsa kuti zitsanzo zimasungidwa pamalo okwanira kuchepetsedwa kuchepetsera kuwonongeka kwa maselo ndi kuipitsidwa, potero kumalimbikitsa mtundu wa maselo a BOO kutalikirana. Chizindikiro - chitsanzo chokonzedwa chimakhazikitsa gawo lotithandizira kudzipatula komanso kugwiritsa ntchito kafukufuku wotsatira.
Njira za B mwachidziwikire
Njira zosiyanasiyana zimakhalapo chifukwa cha kudzipatula kwa ma B, iliyonse ndi zabwino zake ndi malingaliro ake. Pakati pa njira zogwiritsidwa ntchito kwambiri ndi zochulukirapo za centrifugation, magnetic - kukonza masentimita (macs), komanso fluorescence - Njira iliyonse imapangidwa kuti iletse ma B cells kutengera mawonekedwe enieni monga kukula kwake, kachulukidwe, kapena mawonekedwe a olemba pamwamba. Kwa ofufuzawo akuwoneka bwino ndi kulondola, kusankha njira yoyenera komanso yoyenera "B yoyenererana" ndiyofunikira. Kumvetsetsa zikuluzikulu za njira iliyonse kumathandizira ofufuza kuti agwirizane ndi zoyeserera zawo zomwe akufuna.
Magnetic - Kukhazikitsa kwa maselo (Macs) ma cell
Macs ndi njira yotchuka ya b cell cengula, kuti zikhazikike mfundo za kupatukana kwamatsenga ku Chuma Chuma. Mwanjira imeneyi, maselo amalembedwa ndi ma antibodis a magibodies akuwongolera B - Zolemba zapadera. Nthawi inayake, gulu la maginito limayikidwa kuti alekanitse ma beloni a ma a B kuchokera kwa ena onse. Njira imeneyi imayamikira chifukwa chophweka komanso kukonza mwachangu, ndikupangitsa kuti asankhe zosankha zambiri kwa maloboratories ambiri. Omwe aliwonse a Cell Cell Central Cits Church nthawi zonse amakhala ndi zinthu zonse zofunika pa ma Mac, zomwe zimapereka zolondola komanso mtengo - Njira Yothandiza Yoyeserera Padziko Lonse Lapansi.
Ma fluorescence - Kukhazikitsa kwa maselo (kumaso) njira
Nkhope ndi njira yodziwika bwino yomwe imalola kukwera - Chiwonetsero B Cell Cell kutengera mawu a ma antibodies. Njira iyi si yachabele ma B komanso imapereka chidziwitso mwatsatanetsatane za kukula kwa khungu, zovuta, komanso zonena zam'madzi. Kulondola komanso kusinthasintha kwa nkhope kumapangitsa kuti ikhale chida champhamvu pakuyesera kofunikira kuyera kwa maselo akulu ndi zipatso. Kwa ofufuza ambiri, kuyikanso muopanga kwa B Get yomwe imapereka.
Zovuta mu BENO CERELY
Ngakhale kuti akupita patsogolo m'ndende, ofufuza nthawi zambiri amakumana ndi zovuta m'maselo a B. Izi zitha kuphatikizira nkhani monga kuchotsedwa kwa cell, kuipitsidwa ndi mitundu ina yam'manja, komanso kusokonekera kwa ukadaulo. Kuthana ndi Zovuta izi kumafunikira kuphatikiza kwa protocols ndi mkulu - zolimbitsa thupi. Kuphatikizira ndi cell yodalirika b iso Kuphatikiza apo, kukhalabe anzeru zatsopano komanso machitidwe abwino amatha kuthandiza kuchepetsa mavuto wamba omwe amachititsa chidwi.
Kuthamangitsa B Genera
Kukulitsa luso ndi kugwira ntchito kwa ma B cell, ndikofunikira kuti mutseke ma protocols. Zinthu monga mtundu wamphamvu, nthawi zokakamizika, komanso kusamba njira zimatha kukhudzanso thupi ndi chiyero. Kusintha protocol yodzipatula kuti ikhale yoyesera zoyeserera zomwe zingakuthandizeni ndikuyendetsa zofuna za kafukufuku. Kugwiritsa ntchito mafakitale a B omwe amapereka njira zosinthira amalola ofufuza kuti agwirizane ndi njira zawo, ndikuwonetsetsa kuti amagwirizana ndi zofunikira zawo kuphunzira ndi zasayansi.
Ntchito za ma cell a B mwa kafukufuku
Ma cell a b Kugwiritsa ntchito kwawo kumapitilira maphunziro amchenga a Immunsiological kumadera ovuta monga mtundu wa matenda ndi achire. Ma cell a B Kuphatikiza apo, kupita patsogolo pa khansa immunotherapy kudalira kwambiri kumvetsetsa kulumikizana pakati pa ma ma cell ndi zotupa. Kupeza kwa anthu oyera a B
Malangizo Abwino mu Nyimbo za Bonle
Munda wa Blonale ya B ukutuluka mosalekeza, umayendetsedwa ndi kufunika kwa njira zodalirika, zodalirika, komanso zotupa. Maukadaulo omwe akutuluka ndi maluso omwe amalonjeza kuti afotokozere molondola komanso kuchuluka kwa B. Kuphatikizira ndi kutsogolo - Kuganiza B BEL Cell Ogulitsa ndi opanga pamawonetsere kuti ofufuza athe kudula - Pamene matelonono awa akuyamba, amatha kugwiritsa ntchito zomwe amagwiritsa ntchito komanso kuchipatala, kukonza njira zomwe zapezeka komanso njira zochiritsira.
Pomaliza, kudzipatula kwa ma B ndi gawo lovuta kwambiri pakufufuza komanso kugwiritsa ntchito mankhwalawa, kupereka kumvetsetsa kwa maziko omwe amafunikira kuyendetsa. Mwa kukonzekera - zida zapamwamba ndi ma kits, monga omwe amapita m'makampani odziwika ngatiIphase, ofufuza amatha kuthana ndi mavuto auzimu ndikukwaniritsa zofunika zawo za sayansi.
Za Iphase
Kumpoto Mu North Wales, Pennsylvania, a Iphase Bioscies ndi "mwapadera, komanso zatsopano - kugulitsa, kugulitsa, kugulitsa mabungwe azachilengedwe. Kuthana ndi Kukonda Kwambiri ndi Kukhumba Kafukufuku Wasayansi, gulu lathu la sayansi limadzipereka kuperekera mabungwe amtundu wapadera kwa asayansi padziko lonse lapansi komanso kuthandiza ofufuza pasukulu yonse yofunika kwambiri. Kutsata R & D kukhala "zopangidwa zatsopano, kufufuza zam'tsogolo," malo ogulitsa ma R & D, malo ogulitsira, ndi ogawana maiko oposa 12,000.
Post Nthawi: 2024 - 10 - 15 10:52