PDC imaganiziranso mawonekedwe a mamolekyu akulu ndi ang'onoang'ono.Chifukwa chake, kafukufuku wa ADME wa in vitro akuyenera kuganizira za ma peptides akunyumba, zolumikizira, zolipira, ndi PDC.Kumayambiriro kwa chitukuko cha mankhwala, ngati homing peptide ili mu mawonekedwe a polypeptide mankhwala, sachedwa hydrolysis ndipo ali osauka bata. Kukhazikika kwake ndi kulunjika mu plasma kuyenera kuganiziridwa; panthawi imodzimodziyo, mitundu iwiri ya ogwirizanitsa idzatulutsa zotsatira zosiyana za kagayidwe kachakudya, ndipo malipiro otulutsidwa (kuphatikizapo malipiro okhudzana ndi gawo limodzi la cholumikizira) ndi mankhwala ang'onoang'ono a molekyulu a cytotoxic. Ndikofunikira kudziwa ma metabolites a mankhwalawa kuti apange mankhwala. Choncho, PDC yopangidwa ndi ma peptides a homing, ogwirizanitsa, ndi malipiro olipidwa ayenera kuwerengedwa mu kukhazikika kwa plasma, kumanga mapuloteni a plasma, chidziwitso cha metabolite, ndi zina zotero, zomwe ziri zofunika kwambiri pa chitukuko choyambirira cha mankhwala a PDC!
IPHASE "One-stop" yankho lazogulitsa mu vitro DPK kafukufuku
Monga mtsogoleri mu vitro kafukufuku wa biological reagents, IPHASE imatsatira kutsogolo kwa chitukuko cha mankhwala ndikupanga ma reagents osiyanasiyana mu vitro biological reagents pamagulu angapo ndi magawo omwe amayang'ana mu vitro DMPK kafukufuku wamankhwala a PDC kuti athandize PDC kafukufuku wamankhwala!
1.Magawo a subcellular reagents
·Ma microsomes a chiwindi ·Chiwindi S9/Acidified Chiwindi S9
·Chiwindi cytosol ·Impso S9
·Lysosome -Acidified chiwindi homogenate
2.Primary Hepatocyte Products
·Munthu/Nyani/Galu/Khoswe/Mbewa/Nkhumba Yayimitsidwa/Yotsatira PulayimaleHepatocytes
3.Zogulitsa Zamsewu
·ABC family transporters ·SLConyamula mabanja
4.Recombinant enzyme mankhwala
·Mtengo wa CYP ·UGT
5.Zinthu zokhudzana ndi Plasma
·Zida zama dialysis zofananira ·Zoyeserera za Plasma kukhazikika
·Matenda omanga mapuloteni a plasma
6.Matrix opanda kanthu
Nthawi yotumiza: 2024 - 08 - 16 15:26:10