Kunyumba ADME IPHASE Phase II Metabolic Stability Kit, Human

IPHASE Phase II Metabolic Stability Kit, Human

Kufotokozera Kwachidule:

Phase II metabolism, yomwe imadziwikanso kuti Binding reaction, imatanthawuza momwe ma metabolites a gawo loyamba kapena mankhwala ofananira amaphatikiza ndi mamolekyu ang'onoang'ono ang'onoang'ono kudzera mu gawo lachiwiri la michere, zomwe zimapangitsa kuchepa kwa kawopsedwe, zochita, kapena polarity ya mankhwala. Mu gawo lachiwiri la metabolism, zomwe zimachitika kwambiri ndi glucuronidation, pomwe uridine diphosphate glucuronic acid (UDPGA) imamangiriridwa ku prodrug kudzera pa catalyzation ndi glucuronyl transferase mu ma microsomes. Glucuronide yomwe imapangidwa imawonjezera kusungunuka kwa metabolites m'madzi kuti iwonjezere kutuluka. Gawo lachiwiri la kagayidwe kachakudya litha kumangidwanso ndi kuphatikiza kwa ma microsomes a chiwindi ndi UGT ndikugwiritsidwa ntchito pophunzira kukhazikika kwa gawo lachiwiri la kagayidwe kachakudya kwa omwe akufuna kumwa mankhwala mu vitro.

ONANI TSOPANO Onjezani kungolo yogulira

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Kufotokozera kwazinthu

Microsome｜Substrate｜ UGT Incubation System｜ 0.1M PBS (pH7.4)

Gulu:
Zida za in vitro metabolism
Katundu No.:
Chithunzi cha 0112A1.03
Kukula kwa Unit:
0.2mL * 50 mayeso
Thupi:
Chiwindi
Mitundu:
Munthu
Kugonana:
Zosakanizidwa
Zosungirako ndi zoyendera:
Sungani pa - 70°C. Owuma ayezi amaperekedwa.
Mtundu Woyeserera:
Phase II Metabolic Stability Kit (UGTs)
Mayeso System:
Microsome
Kuchuluka kwa ntchito:
In vitro Kuwunika kwa Kukhazikika kwa Metabolic

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IPHASE Phase II Metabolic Stability Kit, Human

Kufotokozera Kwachidule:

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

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