Aiga ADME IPHASE Vaega II Pusa mautu Metabolic, Mouse(ICR/CD-1)

IPHASE Phase II Metabolic Stability Kit, Mouse(ICR/CD-1)

IPHASE Vaega II Pusa mautu Metabolic, Mouse(ICR/CD-1)

Fa'amatalaga Puupuu:

Vaega II metabolism, lea e taʻua foi o le fusifusia tali, e faasino i le tali lea o le vaega I metabolites poʻo vailaʻau faʻataʻitaʻiga e tuʻufaʻatasia ma molelaʻau laiti e ala i le vaega II enzymes, e oʻo atu ai i le faʻaitiitia o le oona, gaioiga, poʻo le polarity o prodrugs. I le vaega II metabolism, o le tali sili ona taatele o le glucuronidation, lea e fusifusia ai le uridine diphosphate glucuronic acid (UDPGA) i le prodrug e ala i le catalyzation e le glucuronyl transferase i microsomes. O le glucuronide e fa'atupuina e fa'atuputeleina ai le vai-solubility o metabolites e fa'aleleia ai le alu. O le vaega II metabolic system e mafai ona toe faʻaleleia e ala i le tuʻufaʻatasia o le ate microsomes ma le UGT ma faʻaaoga e suʻesuʻe ai le tulaga II metabolic mautu o sui tauva fualaau faasaina in vitro.

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