Gida ADME IPHASE Mataki na II Kit ɗin Ƙarfafa Jiki, Mouse(ICR/CD-1)

IPHASE Phase II Metabolic Stability Kit, Mouse(ICR/CD-1)

IPHASE Mataki na II Kit ɗin Ƙarfafa Jiki, Mouse(ICR/CD-1)

Takaitaccen Bayani:

Matsayi na II metabolism, wanda kuma aka sani da ɗaukar ɗaurin kai, yana nufin halayen da lokaci na metabolites ko samfuran samfuri suka haɗu tare da ƙananan ƙwayoyin cuta ta hanyar enzymes na II, wanda ke haifar da raguwar guba, aiki, ko polarity na prodrugs. A cikin lokaci na II metabolism, abin da ya fi dacewa shine glucuronidation, lokacin da uridine diphosphate glucuronic acid (UDPGA) ke ɗaure zuwa prodrug ta hanyar catalyzation ta hanyar glucuronyl transferase a cikin microsomes. Glucuronide da aka kafa yana ƙara ruwa Za'a iya sake gina tsarin tsarin rayuwa na II ta hanyar haɗin microsomes na hanta da UGT kuma ana amfani da su don nazarin yanayin kwanciyar hankali na II na 'yan takarar magani a cikin vitro.

TUNTUBE YANZU Ƙara zuwa keken siyayya