Faatasi ai ma a tatou tekinolosi taʻutaʻua i le taimi lava e tasi ma lo tatou agaga o le fou, felagolagomai felagolagomai, manuia ma atinae, o le a tatou fausia se lumanai manuia faatasi ma le tasi ma le isi ma lau pisinisi faaaloalogia mo manuki-plasma,isumu CD14+, Pusa Tisu Fatafata, cyp2b6, cyp1a2 pusa. Faʻafeiloaʻi tagata faʻatau i le lalolagi atoa e faʻafesoʻotaʻi i matou mo pisinisi ma umi - felagolagomai. O le a avea i matou ma au paaga faʻalagolago ma faʻatau atu vaega taʻavale ma mea faʻaoga i Saina. Afai ei ai se mea e te fiafia i ai, faʻamolemole taʻu mai ia i matou. O le a matou taumafai i le mea sili matou te mafaia e faʻamalieina ai ou manaʻoga i oloa maualuga maualuga, tau sili ona lelei ma vave tuʻuina atu. Fa'amolemole lagona le saoloto e fa'afeso'ota'i i matou i so'o se taimi. Matou te tali atu ia te oe pe a matou mauaina au fesili. Faamolemole ia matau o loʻo avanoa faʻataʻitaʻiga aʻo leʻi amataina la tatou pisinisi.Pusa Suavai Iole, Maile PBMC, Fa'asao le pusa fa'asalalau, pusa cytosol ate.
Folasaga i le Liver MicrosomesMicrosomes o ni fasi vesicular laiti e maua mai le endoplasmic reticulum ma e maua i totonu o sela ate (hepatocytes). Latou te faia se sao taua i meaola eseese
IPHASE, i le avea ai ma taʻitaʻi i meaola faʻaola mo suʻesuʻega in vitro o vailaʻau fou, o loʻo faʻaauau pea ona faʻalauiloaina suʻesuʻega suʻesuʻe maualuga i le tele o matata ma ituaiga e faʻatatau i tausaga o suʻesuʻega ma atinaʻe.
Talu ai ona o le vailaʻau e faʻaaogaina le enzyme e faasolosolo malie ona faʻaitiitia i le faʻaumiumi o le incubation in vitro, o faʻataʻitaʻiga masani in vitro metabolism ei ai tapulaʻa e pei o le taimi faʻapuupuu puupuu.
Folasaga: Taua o Sprague Dawley Rats i Suʻesuʻega Ua avea rats Sprague Dawley ma vaega taua o suʻesuʻega faʻasaienisi ona o latou uiga faʻapitoa ma agavaʻa i faʻasalalauga eseese.
Folasaga i Tritosomes● Faʻamatalaga ma le TauaTritosomes o fausaga faʻapitoa faʻapitoa e aofia ai i le tele o gaioiga feaveaʻi, aemaise lava i le faʻatonutonuina o auala metabolic.
O le in vivo alkaline comet assay ua faʻateleina le faʻaaogaina i le suʻesuʻeina o le genotoxicity o mea faʻapipiʻi. ICH S2(R1) ua aofia ai le liver comet assay o le 2nd in vivo test for tissues/endpoints; a
I le avea ai o se kamupani fefaʻatauaʻiga faavaomalo, e tele a matou paaga, ae e uiga i lau kamupani, ou te fia fai atu, o oe e matua lelei lava, lautele lautele, lelei lelei, tau talafeagai, auaunaga mafanafana ma le mafaufau, tekinolosi ma meafaigaluega ma tagata faigaluega e iai aʻoaʻoga faʻapolofesa, faʻamatalaga ma faʻafouga oloa e talafeagai, i se faapuupuuga, o se felagolagomai manaia tele, ma matou te tulimatai atu i le isi felagolagomai!
Faʻatasi ai ma se uiga lelei o le "manatu i le maketi, vaʻavaʻai i tu ma aga, faʻasaienisi", o loʻo galue malosi le kamupani e fai suʻesuʻega ma atinaʻe. Fa'amoemoe e iai so tatou mafutaga fa'apisinisi i le lumana'i ma ausia le manuia fa'atasi.
O le aufaigaluega a le aufaipisinisi e matua onosai ma e iai se uiga lelei ma alualu i luma i lo tatou fiafia, ina ia mafai ona tatou maua se malamalamaga atoatoa o le oloa ma mulimuli ane ua tatou maua se maliliega, faafetai!