O la matou sini o le faʻamalosia ma faʻaleleia le lelei ma le tautua o oloa o loʻo i ai nei, i le taimi nei e faʻaauau pea ona atiaʻe oloa fou e faʻafetaui ai manaʻoga eseese a tagata faʻatau mo isumu-nk-kit,C57BL/6 pusa plasma isumu, pusa Tisu Pa'u, pusa Hepatocytes taofi, ate S9 vaega ninii pusa. O le saogalemu e ala i mea fou o la tatou folafolaga lea i le tasi ma le isi. Matou te faʻamoemoe e tuʻuina atu oloa ma auaunaga i le tele o tagata faʻaoga i maketi o maketi i le lalolagi atoa; na matou fa'alauiloaina la matou fuafuaga fa'ailoga fa'ava-o-malo e ala i le tu'uina atu oa matou oloa sili ona lelei i le lalolagi atoa e ala i a matou pa'aga ta'uta'ua ma tu'uina atu i tagata fa'aoga i le lalolagi e fa'atasi ma fa'atekonolosi fou ma taunu'uga fa'atasi ma i matou.ugt2b15 pusa, pusa monocyte tagata, atigipusa fa'apipi'i paraffini, Pusa PBMC maile.
C57BL/6, e masani ona ta'ua o le "C57 black 6", "C57", po'o le "black 6" (fa'apuupuuga masani B6), o se fa'atupuina masani o le isumu falesuesue. E fa'aaogaina lautele e fai ma isumu transgenic i su'esu'ega fa'atagata e fa'atusa ai fa'aletonu fa'aletagata.
Talu ai ona o le vailaʻau e faʻaaogaina le enzyme e faasolosolo malie ona faʻaitiitia i le faʻaumiumi o le incubation in vitro, o faʻataʻitaʻiga masani in vitro metabolism ei ai tapulaʻa e pei o le taimi faʻapuupuu puupuu.
O le in vivo alkaline comet assay ua faʻateleina le faʻaaogaina i le suʻesuʻeina o le genotoxicity o mea faʻapipiʻi. ICH S2(R1) ua aofia ai le liver comet assay o le 2nd in vivo test mo tissues/endpoints; a
Revolutionary Therapeutics: Antibody-Oligonucleotide Conjugates (AOCs) - Le Lumana'i o Fa'afoma'i Sa'oI le lalolagi fa'avavevave fa'asolosolo o biopharmaceuticals, Antibody-Oligonucleotide Conjugates
Talu ai nei, IPHASE, faʻatasi ma le Perelman School of Medicine i le Iunivesite o Penisilevania, faʻatasi na tusia se tala i le tusi talaaga Antibody Therapeutics (IF = 4.56) faʻaulutalaina "Atinaʻe o se
Fa'atomuaga i le Rat Liver S9 Rat Liver S9 o se vaega i lalo - cellular fraction e maua mai i le ate, aemaise lava mai isumu, i le mulimulita'ia o se faiga fa'atasi ma le centrifugation fa'apitoa. O loo iai a
O le sui o le aufaipisinisi na faʻamatalaina auʻiliʻili, uiga lelei o le auaunaga, tali e matuaʻi taimi ma atoatoa, o se fesoʻotaʻiga fiafia! Matou te faʻamoemoe e maua se avanoa e galulue faʻatasi ai.
O loʻo i ai i le kamupani punaoa mauoa, masini faʻapitoa, tagata faigaluega poto masani ma auaunaga sili ona lelei, faʻamoemoe e te faʻaleleia atili ma faʻaatoatoaina au oloa ma auʻaunaga, manaʻo ia sili atu!
Faʻafeiloaʻi taimi, faʻatinoina lelei o aiaiga konekarate o oloa, faʻafeiloaʻi tulaga faʻapitoa, ae faʻapea foi ma le galulue faʻatasi, o se kamupani faʻatuatuaina!
O le pipii atu i le pisinisi mataupu faavae o faamanuiaga soofaatasi, tatou te maua se fefaʻatauaʻiga fiafia ma manuia, matou te manatu o le a avea i matou ma paaga sili ona lelei.