Kholiseho ea Linker ea Linker le ho lefa ho lokolla lithethefatsi tsa ADC
Li-antibody - Litšitiso (ADCS) li itšetleha ka li-antised li-a li-antisedies tse ikhethileng - Likamore tsena li aroloa e le sesepa kapa tse sa tsoa fumaneha, ho latela hore na li senya joang ka seleng.
Li-chikers tse hlakileng
Ho na le li-lichiker tse hlakileng tse sa tsitsang, ho nka monyetla ka maemo a phapang lipakeng tsa maemo a ph le bokhoni ba redox. E ka ba e nchafatsoa ka har'a nyopa ka har'a LYSOSOS.
Barekisi ba hlasimolohileng ba lik'hemichi ba kenyelletsa acid - li-bonpeng tse hlokolosi (tse kang tsa carylene kapa li-carbonate tse kang ho sokola). Acid - Linakers tse hlokolosi li senya libakeng tsa acidic, ka ho khetheha ho tsendos (ph 4.5-5.0), e tlolo ea moputso.
Mofuta o mong oa senotlolo oa Linker o hlaphohetsoeng o le mong oa enzyme - o robehile lethathamo la li-hydrolmman hydrolytic hydrolytic hydrolytic hydrolytic hydrolytic hydrolytic hydrolytic hydrolytic hydrolytic hydrolytic hydrolytic hydrolytic hydrolytic hydroltic Har'a tsena, Petide - Lithane tse tsamaisang li-adectionalilalation tsa ADCOs le ho sebetsa ka li-cathepas tsa lysosomal. Enzyme e tloaelehileng - Linkers tse ntle li kenyelletsa GGFG (Gly - Gly - Phe - li-vs. Moralo oa ggfg o ananeloa haholo ke Cathepsin L, e thusang ho lokolloa ka botlalo ho ADC nakong ea lihora tse 72, ha Cathepsin B o bonts'a ts'ebetso e fokolang ts'ebetsong ena. Leha ho le joalo, li-cc tsa ggfg le li-cc li-countavage ka Cathesoskis B lysosomes kapa lisele tsa lisele tsa tumior li tlaba tokollo e sebetsang.
Ha ho bapisoa le acid - Ka mokhoa o ts'oanang, VC Linker e se e tsitsitse plasma mme ka phetela lithethefatsi lisele tsa TUMOR, li netefatsa phano e lebisitsoeng.
Kaha mefuta e mecha e bolokiloeng e fapana ka mochinicha, e khethang tsamaiso e phethahetseng e hlakileng e bohlokoa bakeng sa tlhahlobo ea lithethefatsi. Ho tloaelehile ho li-system tsa liteko tsa vitro bakeng sa ho lokolloa ho acid ea acidibited Khetho ea sistimi e itšetlehile ka mofuta oa teko ea linker
No - Barekisi ba Hloekileng
Batho ba sa tsoakoang ke ho senya li-antibodies tse felletseng tsa li-antibodies tsa li-anti-mafu Leha ho le joalo, katleho ea bona e itšetleha ka botebo ka lisele tsa lisele tsa tumor le bokhoni bo matla ba lithethefatsi tse kopaneng ho netefatsa ho lokolloa hantle.
Bakeng sa lithuto tsa vitro, litsamaiso tsa liteko tse kang li-acid tse acidi tse nang le li-maver tsa acidi tse nang le li-sebete, le lysosomes li ka senya karolo ea antibody, e tsamaisang chelete. Litsamaiso tsena li bohlokoa bakeng sa ho hlahloba thepa ea pharmacokineetic ea li-adcs tsa admacokinetic ea li-adcs tse sebelisang li-li-haufi.
Mantsoe a bohlokoa: ADC Linker, ho lokolloa ho, li-lysomel, tsitsipano, Cathesin B, Ds8201A, GGFG - DXD
Nako ea poso: 2025 - 03 - 21 12:009