ADME
Ha ho etsoa tlhahlobo ea pharmacokinetics, karolo ea bohlokoa ea tlhahlobo ea pharmacological ea preclinical, adsorption, distribution, metabolism, and excretion (ADME) thepa e tlameha ho hlakisoa nakong ea nts'etsopele ea lithethefatsi. Metabolism ea lithethefatsi, kapa biotransformation, e bolela mokhoa oo sethethefatsi se bang le liphetoho tsa sebopeho sa lik'hemik'hale bakeng sa ho monya le ho felisoa 'meleng. E arotsoe ka karolo ea I & II metabolism, biotransformation e hlaha haholo sebeteng, setho se matlafalitsoeng ka li-enzyme tsa metabolic, hape le lithong tse ling tse kang mala, liphio, matšoafo, mali le letlalo.
Taba ea bohlokoa, e rarahaneng mabapi le metabolism ea lithethefatsi ke ho hlahisa liphuputso ho theha likamano bakeng sa ho bolela esale pele boitšoaro ba lithethefatsi tsa metabolic ho batho, katleho ea lithethefatsi le polokeho. Lilemong tse 'maloa tse fetileng, IPHASE e hlahisitse lihlahisoa tse ngata bakeng sa lithuto tsa metabolism ea lithethefatsi tse kenyelletsang botsitso ba metabolism, metabolic phenotype, enzyme inhibition (IC).50). Ho feta moo, IPHASE e boetse e fana ka mekhoa e metle ea in-vitro e kang hepatocyte e ka sehloohong, sebete le mala a microsomes, karoloana ea S9, cytosol, CYP recombinases e bokelitsoeng ho tsoa mefuteng e itseng linaheng tse sa tšoaneng.