Lithethefatsi - mori oa lithethefatsi tse kopanyang mehopolo le mecha

Kenyelletso ea lithethefatsi tsa ADC

Antibody - Litšitiso (ADCS) li emela sehlopha sa mofets'e Ka ho kopanya li-antibodies tsa monoclon tse nang le li-anti -us tse nang le cytotous tse nang le cytotous, li-adc li tlisa lithethefatsi ka kotloloho ho lisele tsa mofets'e. Pele o ile a bonoa ka bo-1980, ADCS e bile kalafong e netefalitsoeng ka ho hlaka, e kenyelletsa le li-fdavin.

Likarolo tsa mantlha tsa ADC

ADCS e na le lintho tse tharo tse mahlonoko:

• - Antibody:Antibody ea Monoclon (Mab) e tlamang ho mofetoa - Lintlha tsa antibody li tšoaea liketsahalo tsa lisele tsa mofets'e.
• - Linker:Bridge ea lik'hemik'hale e hokahanyang antibody ho lefa lekhetho. Bongoe ba eona bo nka qeto ea hore na moriana o lokolloa maling kapa ka seleng ea mofets'e.
• - Payload:Sekhahla sa likotoana (e.g.

- ADC L ADRYRY

Linako li na le matla ho ho lekanya adc le ho sebetsa hantle le katleho. Ba oela ka mekhahlelo e 'meli:

1. Li-chikers tse hlakileng

Tsena li lokolla moputso tlasa maemo a itseng a ho kenella:

• - PH - Lintletse tse hlokofatsang:Nyenyefatsa libakeng tsa Acidic (e.g., Endosomes / lysomes). Mohlala: HYDAZON LIHLYSY tse sebelisitsoeng Mylottarg® (Gemtuzumab Ozogamicin).
• - Enzyme - Linkers tsa bohlokoa:E hloekisitsoe ke litlhahlobo (e.g., cathepsin b) kapa phosphathes. Mohlala: Valaine - Litlers in Adcetris®.
• - Mokhotlo oa bana - li-linki tse hlokolosi:Itšetleha ka maemo a phahameng a bo-actracellular a tsoang ho a roba litlamo tsa ho sotha.

2. - Basele ba nang le li-mano

Tsena li hloka phepelo e felletseng ea li-antibody e nyoneloa ho lokolla moputso (e.g., thiotherher linkers ka Kadsyela®). E hana - Likhaki tse hlakileng li fana ka botsitso ba makhoaba empa ba fokotsa phello ea bona.

Lefapha la ho lokolla menyako

Mochini oa ho lokolloa ha lithethefatsi ho its'etleha ho mofuta oa lisker:

1. Li-chikers tse hlakileng:

• - Tikoloho ea Acidic:PH -
• -Lipelaelo tsa LYSOOSOS BROKES INCOETSI.
• - Phokotso:Liphetoho tsa mokoloko tse phahameng lisele tsa kankene li fokotsa litlamo tsa ho sokela.
• - Ho qala hantle:Lits'ebeletso tse bolokiloeng li ka etsisa lisele tsa boahisani, li na le molemo lisito tsa tierogeneus empa li le kotsi bakeng sa lisele tse haufi tse haufi tse haufi tse haufi ka ho fetisisa tse haufinyane.

2. No - Barekisi ba Hloekileng:

• Antibody e na le li-vesosomosis ho lysosomes, ho lokolla payload (e.g., Lysine - MCC -.Ha ho na mokhoa oa ho ameha, o ka fokotsang - ho na le chefo e nang le chefo.

Liphephetso le Litaelo tsa Bokamoso

• - Khetho ea sepheo:Ho lula li-antigrax haholo ka li-tuman ho li qoba - Shebella / Off - Ho na le chefo.
• -Ho leka-lekanya botsitso le ho kenngoa lithethefatsi tse sebetsang hantle ho ntse ho bohlokoa.
• - Index ea therapetic:Ho Ntlafatsa Sethethefatsi - Ratio ea Antiboghor le Mahlale a Kopaneng (E.G.
• - Ho Ntšetsa pele:Li-antibodies tsa Buspecific, Prodrug

Sephetho

ADC e fana ka mohlala oa ho hlonama ha moriana le Oncogegy, ho fana ka tharollo ea tatellano ea tumello ho loantša kankere. Ha e le mahlale a masholu le patsa - Moloko oa ADC o Tšepahala ka Mahlabula a Phokotso ea Sechaba sa Kankere ea Sejoale-joale.

Mantsoe a bohlokoa: ADC Linker, ho lokolloa ho, li-lysomel, tsitsipano, Cathesin B, Ds8201A, GGFG - DXD