Kenyelletso eaLitereke tsa mantlha tsa mantlha
Likhechana tsa mantlha ke sekhobo sa sebete sa Liver Ha mofuta oa ka sehloohong oa sele e fumanehang ka har'a sebete, hepatocytes e na le tse ka bang 70 - 80% ea boima ba li-cytoplasmic. Ba bapala karolo ea ho sebelisa melaetsa ea metabolis, detoxiation le protheine Syntthesis. Sengoliloeng sena se fetela lefatšeng le rarahaneng la li-apatocytes tsa mantlha, ho hlahloba bohlokoa, likopo tsa tsona le litsela tsa tlang.Ho itšehla thajana le setso sa hepatocytes
● Mekhoa ea ho itšehla thajana ea hepatocyte
Lithako tsa mantlha li arotsoe ho lisele tsa sebete ka mokhoa o hlokolosi o lokelang ho tšosa holimo - Ts'ebetso ena hangata e kenyelletsa ho hlonama ha sebete ka sekhahla sa ho khelosa lisele tse tsoang li-hepatocytes. Boleng ba likheoketso bo fumanoeng boala ke hola feela, joalo ka ha e lekanyetse taelo ea bona ho lipatlisiso le likopo tsa bongaka.● Liphephetso tsa moetlo oa lefutso
Baemeli ba mantlha ba mantlha ba beha mathata a maholo, haholo-holo ka lebaka la chelete ea bona e fokolang ea bophelo ba bona ba ho lahleheloa ke sebete - mesebetsi e tobileng ea nako. Ho boloka Lefapha la Bophahamo - Tsoelo-pele ea mekhoa ea moetlo, ho kenyeletsa CO - Litsamaiso tsa Moetlo le Boraro - Scarils Sceads, li ntse li ntlafatsoa ho hlola mefokolo ena.Karolo ea HEPATocytes ka sebete
● Mesebetsi ea metabolic ea HEPACTTES
Li-futatocytes tsa mantlha ke matla a matla a sebete, a ikarabellang bakeng sa litsamaiso tsa bohlokoa, ho kopanyelletsa le gluconeones, polokelo ea glycogen, metabolism. Ba bapala karolo ea bohlokoa ba bolokang Glucose le LipiID ba li etsang thutong ea mafu a bophelo bo kang lefu la tsoekere e kang lefu la tsoekere le botenya.● Lits'ebetso tsa mofuta
Litereke tsa hepatocytes li le bohareng ba dintho tsa barekisi le tse ntle, ho kenyelletsa le lithethefatsi le chefo. Ka karolo ea I le moloko oa II ea metabolic, e tataisang ke li-enzchrome p450s, likhukhuni tsena tse eketsehileng - Ho utloisisa lits'ebetso tsena ho bohlokoa bakeng sa nts'etsopele ea lithethefatsi le ho lekola hepatotoxicity ea metsoako e mecha.Likopo tsa semeche sa lithethefatsi le tlhahlobo
● Litheto tsa pharmacokitics
Ha ho fumanoa lithethefatsi tsa lithethefatsi, liqhomphutha tsa mantlha li bohlokoa bakeng sa ho ithuta phapanoConikotic, lekala la meriana le amehile ka ho sisinyeha ha lithethefatsi ka 'mele. Li sebelisetsoa ho lekola ho monya, ho ajoa, metabolism le lithahasello (adme) tsa batho ba bangata ba bangata ba lithethefatsi. Joaloka Motlatsisi ea etellang pele oa lefu la pele la lefu la pele, lik'hamphani li leka ho fana ka liphiri tse tsamaisanang le liphaknoloji tse nepahetseng le tse tšepahalang.● Toro ea ho ithuta tse fapaneng e sebelisa li-lefutso
Primitop Zpatocytes e bapala karolo ea bohlokoa lithutong tsa deffeololos, tse nolofalletsang bafu ho lekola phepelo ea hepatothara ea lithethefatsi tse ncha le lik'hemik'hale. Ho fumaneha ha PUP - Bacha ba boleng ba boleng bo holimo ba boleng ba boleng bona, ha ba lumella tlhahlobo ea liketso tse ka bang sarapeutic tse sireletsehileng.Hepatocytes ka kalafo ea ntlafatso
● Sebelisa litlhare tsa bocha tsa sebete
Bophahamo ba lefu la mantlha la lefu la mantlha la kalafo ea bocha bo boholo, haholo maemong a li-transplant le sebete. Patlisiso e tsepamisoa ke ho sebelisa li-atticytes tsa ho holisa lisebelisoa tsa boriti le maqhubu a selefouno tse ka nkang mosebetsi kapa ho tšehetsa mosebetsi oa sebete.● Tsoelo-pele ea Liineue Tissuering
Li-tissue tsa sebete tsa lisele li ikemiselitse ho theha li-tis tse sebetsang tsa sebete ho tloha li-apatocytes tsa mantlha. Tsoelo-pele ea tšimo ena, e kang nts'etsopele ea maballo a biocfol e entsoeng ka biocfolfolds le tse tharo -Mechine ea moleng oa li-molecular ho Hepatocytes
● Ho tlisoa lipapatso tsa mahlale
Baeti tsa mantlha ba kenya letsoho litseleng tse rarahaneng tse patehileng tse kenyelletsang ts'ebetso ea sebete, ho kenyeletsoa Glucose Metabolism le Biile Asid synthesis. Ho utloisisa mekhoa ena ho fana ka leseli la ho hlasimoloha melao ea sebete le ho tšela tsela ea ho nts'etsapele liphofutso tse ncha tsa kalafo bakeng sa mafu a sebete.● Ho buisanoa ka taelo ea Gene
Melaetsa ea mofuta oa Gene ho Hepatocytes e bohlokoa bakeng sa ho boloka sebete - Mesebetsi e tobileng. Mekhoa e kang RNA ea tatellano ea RNA le Cisric -Phapang lipakeng tsa li-Ipatocytes tsa mantlha le tse ling
● Khothatso ea mantlha ea hepatocytes
Tsoetsana ea mantlha e khetholloe ke mela e sa shoeng e sa shoeng haholo-holo ka ho hloka matla. Ha mealo ea sele e sa shoeng e etsa moea oa setso e senyehileng, hangata e haelloa ke bophelo ba sebete - Mesebetsi e Meholo ea Boitsebiso bo Ratoang bakeng sa lits'ebetso tse ngata.● VIVO vs. Liphapang tsa Vitro
Lifetlisiso tsa vitro li sebelisa li-Hepatocytes tsa PrimTictes li tlameha ho ikarabella bakeng sa liphapang tse bonoang lipakeng tsa VIVO le maemong a Vitro. Liphapang tsena li ka ama Exchangtion ea liteko tsa tlhahlobo le lipale tsa pathogical, li hatisa tlhokeho ea tloaelo ea setso e ntlafalitsoeng e kopanyang tikoloho ea vivo e sebetsang ka har'a vivo.Litereke tsa mantlha tsa mantlha tsa mofuta oa mefuta ea mafu
● Model mafu a sebete
Likhechana tsa mantlha li bohlokoa ho ea bohlokoa mafong a sebete, ho kenyeletsa le hepatitis, Cirshosis le mofetše oa mofetše. Ka ho iphetetsa lintho tse nchafatsang vitro, bafuputsi ba ka ithuta tsoelo-pele ea mafu le ho leka kutloisiso ea boitšoaro bo botle, ho ntšetsa pele kutloisiso ea rona ea sebete mashano.● Ho utloisisa hepatocyte - mashano a amanang
Ho senyeha ha hepatocyte ho le molemong oa mafu a mangata a sebete. Ho ithuta li-Ipatocytes tsa mantlha ho fana ka leseli ka mekhoa ena, ho tsamaisa nts'etsopele ea matšoao a tšohanyetso le maano a kalafo.Mathata le Mefokolo ho Patlisiso ea Tpatocyte
● Boithaba-hloko le litaba tse sebetsang
Phephetso ea mantlha Patlisisong ea Hepatocyte e boloka seli le ts'ebetso ea lisele ka nako e telele. Kamohelo e lekanyelitsoeng ea proligration ea li-Hepatocytes e hloka tšebeliso ea mekhoa ea tloaelo ea tloaelo le mekhoa ea media ea ho leleka bophelo ba bona le ho boloka ts'ebetso ea bona.● Mefokolo ho ea Long -
Long - Botsotso ba Bothata ba Litokelo tsa Bochabela bo lula bo le teng, kaha li-atpricytes li lula li lahleheloa ke sebete sa bona - litšobotsi tse ikhethang ha nako e ntse e tsamaea. Patlisiso e tsoelang pele e shebane le mekhoa ea setso ea Mefuta e tšehetsang nako e telele - Lisele tsa Sebete tsa Harpatocymal.Likabelo tsa nako e tlang ka Patlisiso ea Hepatocyte
● Ho qaptjoa Theknoloji ea Hepatocyste
Tšimo ea lipatlisiso tsa Zetocyte e fetoha hantle ka potlako, e lelekiloeng ke tsoelo-pele ea mahlale le ho hlahlojoa ha setso le ho sekaseka. Mekhoa ea Bochaneong, lisebelisoa tsa Microflugic, lisebelisoa tsa Microfluidic, ho kenya tšebetsong ho hlahlobisisa likopo tsa boithuto ba PUPYAY.● TLHOKOMELISO EA LITLHAKISO TSA BOPHELO
Li-Vepatocytes tsa mantlha li na le tšepiso ea moriana o ikhethileng, haholo-holo ho kalafo ea lithethefatsi ho bakuli ka bomong ho ipapisitse le profotolelo ea bona e ikhethang ea sebetesolism. Bokamoso ba lipatlisiso tsa Zekocyte bo amana le botsoalle bo kopaneng le bothethefatsi, le metabolomic, le Metabolomic, le Metabolomic ho fihlela maano a kalafo bakeng sa mafu a sebete le a fetang.Phetha: Karolo ea Bohlokoa ea HEPATYTES le kenyelletso ea k'hamphani
Litopo tsa mantlha li lula li na le lisebelisoa tsa mantlha libakeng tsa lipatlisiso tsa biomedical, lijana tsa lithethefatsi le moriana oa bocha. Liphephetso tse tsoelang pele le tse ling tse ntlafalitsoeng tsa Titecyte li totobatsa bohlokoa bo haellang sa lisele tse hanang mesebetsing e rarahaneng ea batho le bophelo bo botle ba motho.Kantle-hlooho ho la North Wales, Pennsylvania,IphaseLi-Biosciens ke tse ikhethang, lipale, 'me ke bukana ea Iketsang - Phetoho ea Teknoloji ea Reagansosa a koetliso ea likokoana-hloko. Ka tsebo e eketsehileng le takatso bakeng sa lipatlisiso tsa saense lefatšeng ka bophara, li thusa bafuputsi ho fihlela sepheo sa ba saense ea tse fetang 2 000 -
Nako ea poso: 2024 - 12 - 09 10:22: