Semelo
Ka lebaka la litšobotsi tsa eona tse ikhethang tsa theknoloji, lithethefatsi tsa sirna e se li tsepamisitse maikutlo ho tsejoe tšimong ea lithethefatsi tse ncha tsa lithethefatsi le ntlafatso e hlahisoang ka potlako ea gene hajoale. Ha e bapisoa le lithethefatsi tse nyane tsa sebopeho le lithethefatsi tsa Sirna, li ka kenella ho tsoa ho se nang le sethethefatsi, se nang le mathata a mangata "ka ntle ho leqhubu la boraro la meriana. Leqhubu la boraro la meriana ntle le lithethefatsi tse nyane tsa molek'hule le lithethefatsi tsa mehleng.
Leha ho le joalo, joalo ka sehlopha se secha sa li-molecales, se lithethefatsi se qosa, se hlokang phephetso e ncha ea lithethefatsi tsa Sirna.
Kenyelletso ea lithethefatsi tsa Sirna
Lithethefatsi tsa Sirna, hape tse tsejoang ka hore O Oligonucleocleotide (Li-Ons), sheba lithethefatsi - Ogenucleotides ka tloaelo 18 - 30 nt bolelele. Lithethefatsi tse nyane tsa RNA li kenyelletsa rna (Sirna), Osolsen RNA (Mirna), moetsi oa RNA (MRNA), APSNAR, ATRIBGINLE
Patlisiso ea hajoale e shebane le mefuta e meraro ea lithethefatsi tsa Sirna lithethefatsi: ASO, Sirna le APPabar. Oligonucleonide e fapaneng e na le mekhoa e fapaneng ea ketso, 'me ba bapala karolo ea batho ba li-pathogeneis tsa Pathogeneis. Aso le Sirna ba sebetsa maemong a 'ona a reriloe. APPaMamer o thibela mosebetsi oa liprotheine tse kentsoeng Pathoeneis. Taba ea bona e tloaelehileng ke hore li kenella ka polelo ea patsi tsa lefutso tsa mefuta ea lefutso tsa mefuta ea lefutso ho fihlela sepheo sa kalafo.
Ka kakaretso, mochine o ikhethang o etsa hore lithethefatsi tse nyane asiti tsa nyutlelie e na le melemo e mengata le potoloho e matla, bolelele ba lipatlisiso, le nts'etsopele, e nkoang e le moloko oa boraro oa theknoloji ea litlhare tse tla khothaletsa phetoho ea indasteri ea meriana e latelang lithethefatsi tse nyane le lithethefatsi tsa tlhaho tsa moletsoana. Likhamphani tse ling tse ngata tsa meriana li tsetetse lipatlisiso le nts'etsopele ea lithethefatsi tsa Sirna.
Boemo ba litlhahlobo tse nyane tsa nyutlei tsa nyutledi e bohareng
O amohetse litlhare tse nyane tsa nyutleiti sa acid.
- Oligonucleotides (asos): Tsena e le 'ngoe - DNA Molecules li tlama ho tobileng tsa Monghali. ASOS e bohlokoa e kenyeletsa:
- Nusinnern (spinraza): E amohetsoe kemiso ea methapo ea pelo ea mesifa.
- Eteprirsen (exondys 51): The fuftss duchenne mesifa ea dystrophy.
- Inodesen (Tegesedi): Ho ts'oarana le lefu la pele ho nako - Amyloidosis ea litaba.
- Rnas e nyane ea ho kena-pheta: habeli - Double Helena
Litlhare tsa Sirna li kenyelelitsoe:
- Patitiran (ONPATTRO): FDA ea pele - Setlhare se Finyelloang Sirna, Ho sebetsana le TRENTYRENT - Amyloidosis ea lefapha.
- Givosiran (Givlaari): Ho sebetsoa ngagramaria ea Hepatic.
- Lumasiran (Oxlumo): Thepa ea mantlha ea Hyperoxoaria 1.
- Baeti: Khahla-mumbity Nucleic acid ea nyutlelie e hokahanyang liprotheine tse ikhethang.
- Pegaptanib (Macugen): The Apater e amohetse lilemo - Atang Prinwaration e amanang.
Mantsoe a bohlokoa: galnac - Sirna Scecord, Liver Lysosomes, Tritosomes, tsitsipano ea Mahala, boiketlo ba acid acid
Nako ea poso: 2025 - 04 - 09 10:04:06