Lipapatso le likarolo tsa tsona ho li-rivilogy

Lipapatso le likarolo tsa bona

Lipapatso ke sehlopha se pharalletseng sa protheine ea Transmembrane e nang le selefounu ea lisele tse ngata (ka tlhaho e etsahala ka har'a setho) le batho ba kantle ho naha). Liprotheine tsena tsa membrane tsa membrane li sebetsa e le balemi ba limolek'hule ba ho laola tikoloho ea cellular ka ho netefatsa hore le ho cheka haholo hara lesimo la bona la mahloriso. Maemong a likhahla tsa phetolelo, "ho fetisetsa lipapatso tsa lithethefatsi Malapa a mabeli a maholo a laola ts'ebetso ena: The Atp - Lingoliloeng tse tlama (ABC) Superfamily le Slc) Superriert.

Lipalopalo tsa ABC: ATP - Li-Gangkeepers

Lipapatso tsa ABC ke li-gangnder tsa ka sehloohong hore li-sublysis tse fapaneng ho tsamaisa likotoana tse fapaneng, esita le lithethefatsi - li-rantish tsa li-arf. Holsparmark ea lipapatso tsena ke li-nucleotide tse hlophisitsoeng hantle - Boine ba bona - Ts'ebetso ea Ts'ehetso e Ikhethileng Feela Feela e Lekanang le ho Boloka Metabolication ea Metabolic Empa le ea ho kenya letsoho ho hanyetsa lithethefatsi. Mohlala, ka ho ela ka mokhoa o mafolofolo mahlakore a hmotherapeperic ho tsoa ho lisele tsa mofetše, ka hona li etsa hore ho hanyetsa ho hanela chelete (MDR).

Lipapatso tsa slc: litsamaiso tse sebetsang le tsa bobeli

Ho fapana le lipakarolo tsa ABC, litho tsa Slite Carrier (SLC) li feta hangata ha li hloke hydrolysis e tobileng. Sebakeng seo, ho na le liphetoho tse ngata tsa slc hangata e le basebetsi ba sebetsang ba sebetsang kapa ba lokiselitsoeng. Ba sebelisa chelete ea motlakase ea electrochemical hangata e hlahisoang ke ion pumps - ho khanna ho phahamisoa kapa ho lokolloa ha likarolo tse ling hape e kang Glucose, "litsi tsa manyolo. Lithethefatsi tse ngata tse isitsoeng hydrophilic kapa li bonts'a ho nepahala ho ipolelang ka membrane tse tlase ho itšetleha ka lipalangoang tsena tsa ho kena le mosebetsi o latelang. Hobane li khangoa ke li-gradients tsa ion ho fapana le ho atjha

Afduclux

Morerong ka kakaretso oa lipalangoang tsa lithethefatsi, lipathi tse itseng li khethehileng bakeng sa lithethefatsi tsa lithethefatsi, ha tse ling li thusa ba bang ho holisa ho holisa lithibela. Lipapatso tsa Efflux, haholoholo ho tsoa lelapeng la ABC, sebelisa ATP Hydrolysis ho tlosa likhakanyo tse mafolofolo ho lisele. Ts'ebetso ena e bohlokoa bakeng sa ho fokotsa ho kena-kenana le lisele tsa polokelo le bakeng sa ho sireletsa litho tsa litho tse tebileng. Hangata lipapatso li qala, haholo-holo ka lapeng la Slc, haholo li sebelisa lithethefatsi le limolek'hule tsa lisele ho lisele, li netefatsa liketso tsa bona tsa phano libakeng tse patehileng. Ka bobeli, ketso e hokahaneng ea efflution ea EFFFlux le Lipapatso tsa Urtake li nka mofuta oa plasma, ka har'a metsoako e mengata ea kalafo, ka tsela e ka thōko e ka baka katleho.

Lipalangoang tsa bohlokoa le likarolo tsa bona

MDR1 (P - Glycoprotein, ABCB1)

E le e 'ngoe ea lipapatso tsa ABC e ithutileng haholo, MDR1 (e tsejoang ka hore ke P - - GP) Ka lithethefatsi ka mafolofolo le li-Xonenobios li tsoa ka lisele, p - limmating ho monyang oa molomo mme o netefatsa ho thejoa kapele ho tloha tsamaisong ea methapo e tlase. Ka tlisoang ke tšilafalo ea p - GP ka har'a li-touctor ke ho hanyetsa maano a mangata kapa ho nka nako ea li-chemo bohle tse sitisang tšebetso ea tsona. P - Bokhoni ba GP ho tsamaisa metsoako e mengata ea metsoako e sa amaneng le moriana oa lithibela-mafu.

BSSP (Bile Sail Of About Pompo, ABCB11)

BSP ke sebete - Translage e ikhethang ea ABC e bohlokoa bakeng sa secre e loketseng ea Bileecis ho tloha ho Tsoha ho tsoa Cataliculi. Ts'ebetso ena ke ea bohlokoa bakeng sa tšilo ea lijo le ho monya litoro tsa lijo le bakeng sa ho boloka Bile Acid Homeessasis. Pheko ea ts'ebetso ea BSEP - ebang ke ka liphetoho tsa tšebeliso ea li-gebelica kapa lithethefatsi - Litlhahiso tse susumetsang Mafu a Boholo-holo a Li-raples tsa bokhabane a ka tsoela pele ho phetetso e matla, a etsa hore lihlekehlelle tse tebileng tsa ho hlahlobisisa li-hepatotoxic tsa heketotoxic ho sebetsana le maemo a amanang le chostatic.

BRCRP (Kankere ea kankere ea matsoele e hanyetsa protein, ABCG2)

BCRP ke ATP e 'ngoe hape - overlust Translarer e hlahisoang haholo ka liseleng tse kang Prusntana, sebete, malakabe-bokoang ke mali. Maemong a ho lahla lithethefatsi, BCCPP e lekanyetsoa ho pepesetsoa li-chemotherapetics le lithibela-mafu, ka ho li potholla ka liseleng. Sebaka sa eona sa ho hlonepha ka lisene tsa lisele li thusa ho sireletsa masese le kelello ho tsoa li-XenOobootic. Phapang ea liphatsa tsa lefutso kapa pontšo e fokolang ea BCCRP e ka fetoa ke ho hanela chemitherapy, e e etsa sesosa sa meriana ea bongaka le pharmacokineec profiling.

Mate1 / Mate2 - K (Multidrug le Proxico Express)

Bapalami tsena ke karolo ea SLC SuperFymalily 'me e hlahisoa haholo ka lisele tsa bocha le tsa hepatic. Mate1 le Mate2 - Sehlopha se kopanetsoeng le Bascolically Ho Lahla Liphoso tsa Lithethefatsi le Chexins. Ka ho felisa lintho tse ka feteletseng ka har'a moroto kapa sehlahla, liprotheine tsena li thusa ho boloka tumello ea lithethefatsi le ho fokotsa chefo ea mahlale. Botšepehi ba bona bo sebetsang bo bohlokoa bakeng sa ho thibela ho bokella lithethefatsi, bo ka lebisang liketsahalo tse bohloko tse kenyelletsang batho ba nefrokolotho.

Oatp1b1 (Anion ea Orion e tsamaisa polypeptide 1B1, SLCO1B1)

Ha e se e hlalositsoe ka har'a sisoluridal, oatp1b1 ke senotlolo sa ho tsamaisa lithethefatsi tse fapaneng, ho kenyelletsa lihlahlo, lithibela-mafu le lithibela-mafu. Tsamaiso ena e etsa mosebetsi oa bohlokoa ho feta ea metsoako e joalo joalo ka Bilirubin, e kopanyang le li-steroid le lihormone tsa qoqotho le litabeng tsa qoqotho le litafole tsa qoqotho. Boholo ba mofuta oa slco1b1 ba ka ama haholo lipere tsa lithethefatsi hantle haholo, ka mohlala, ka ho fetola litekanyetso tsa lipapatso tsa li-Stathamine le ho eketsa kotsi ea myoputh. Ka lebaka leo, oaatp1b1 ke tsepamisa mohopolo bohareng ba meriana le meriana ea motho e mong.

Oat1 (Onion Anion Transsaer 1, SLC22A6)

Oaat1 o hlalosoa haholo ka basmbrane ea basluteral esele ea khalase ea tuximal e nang le boikarabello ba mefuta e mengata ea linyeoe. Karolo ena e kenyelletsa metaboli ea baloang ke li-forolize tse kang tsa Urate le ea Cyceletidens - Empa li-cyphoni tse tsoang ho li-anti - li-chefi ea tikoloho. Phapang ho Ts'ebetso ea Oat1 kapa poleloana e ka susumetsa lipere tsa lithethefatsi mme e kentse letsoho lithethefatsi - Tlooloa Nephrotoxicity. Karolo ea Tsamaiso ea Pele ea Tsamaiso ea Renal e etsa hore e be letšoao la bohlokoa bakeng sa ho bolela le ho laola karabelo e mpe ea lithethefatsi ho liphio.

Kakaretso ea kakaretso le li-clalinical

Ka bobeli, lipalangoang tsena li beha marang-rang a rarahaneng a ho a monya, ho ajoa, metabolism le litlatsetso (adme) tsa bohlokoa ho pharmacotherapy. Ketso eo ba kopantsoeng ha e susumetse ts'ebetso ea kalafo le ho ba le tšitiso ea bohloeki, ho tloha ho sebopeho sa pherekano le ho buisanoa ka mokhoa o ikhethileng le puisano. Nts'etsopele ea lithethefatsi, ho utloisisa litšobotsi le phallo ea liphatsa tsa lefutso tsa lipalami tsena li bohlokoa. E thusa ho feta ho senya lithethefatsi - Tšebelisano ea lithethefatsi, ho inkela lihlomo tsa kalafo, le ho fokotsa litlamorao. Bafuputsi le bao ba bonoang ba sebetsa ho senola mekhoa e qaqileng ea ketso ea lipalangoang, ba etsang hore ba hanyetse e le lithethefatsi tse fokolang - bobe ba liphio.

Mantsoe a bohlokoa: ATP -, Translaer ea ABC, Mate2, Mate1, Mate1 Mock, mock slc Translaer