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The in vivo alkaline comet assay has been increasingly used in the genotoxicity evaluation of compounds. ICH S2(R1) has included the liver comet assay as the 2nd in vivo test for tissues/endpoints; an
Introduction to Rat Liver S9
Rat Liver S9 is a sub-cellular fraction obtained from liver tissue, particularly from rats, following a specific homogenization and centrifugation process. It contains a
Introduction to Liver Microsomes
Microsomes are small vesicular fragments derived from the endoplasmic reticulum and are found within liver cells (hepatocytes). They play a crucial role in various bio
Introduction to Tritosomes
● Definition and Significance
Tritosomes are specialized subcellular structures involved in various cellular processes, particularly in the regulation of metabolic pathways
● Introduction to chromosome aberration tests
Chromosome aberration tests are crucial tools in genetic research and clinical diagnostics. These tests are designed to identify and characterize structur
The isolation of Peripheral Blood Mononuclear Cells (PBMC) is a crucial technique in biomedical research and clinical applications. These cells include lymphocytes (e.g., T cells, B cells, NK cells) a
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