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Since the drug metabolizing enzyme activities gradually decrease with the prolongation of in vitro incubation time, traditional in vitro metabolism models have limitations such as short incubation tim
Introduction to Rat Liver S9
Rat Liver S9 is a sub-cellular fraction obtained from liver tissue, particularly from rats, following a specific homogenization and centrifugation process. It contains a
Antibody-Drug Conjugate (ADC) is a relatively new type of biotechnology drug which couples small molecule therapeutic compounds to targeting antibodies/antibody fragment by linkers.
Introduction: Importance of Sprague Dawley Rats in Research
Sprague Dawley rats have become an integral part of scientific research due to their unique characteristics and versatility in various expe
Introduction to Liver Microsomes
Microsomes are small vesicular fragments derived from the endoplasmic reticulum and are found within liver cells (hepatocytes). They play a crucial role in various bio
The in vivo alkaline comet assay has been increasingly used in the genotoxicity evaluation of compounds. ICH S2(R1) has included the liver comet assay as the 2nd in vivo test for tissues/endpoints; an
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